STRINGSTRING
Septin4 Septin4 Kdm1a Kdm1a Kitlg Kitlg Cd109 Cd109 Vegfc Vegfc Mpl Mpl I79_009043 I79_009043 I79_009041 I79_009041 Taf4b Taf4b Hoxa3 Hoxa3 Nfatc1 Nfatc1 Nfib Nfib Runx2 Runx2 Atxn1l Atxn1l I79_007190 I79_007190 I79_007189 I79_007189 Ncoa3 Ncoa3 I79_006792 I79_006792 Hnrnpu Hnrnpu I79_006254 I79_006254 I79_006225 I79_006225 I79_005638 I79_005638 Irf6 Irf6 Zfp36l1 Zfp36l1 I79_004031 I79_004031 I79_002659 I79_002659 I79_002496 I79_002496 Cdkn2c Cdkn2c I79_001871 I79_001871 Tgfbr2 Tgfbr2 I79_001484 I79_001484 Tbx3 Tbx3 I79_001046 I79_001046 I79_000973 I79_000973 Tp63 Tp63 I79_000445 I79_000445 I79_019149 I79_019149 Tgfb1 Tgfb1 Sox18 Sox18 Tial1 Tial1 I79_021808 I79_021808 I79_022034 I79_022034 I79_022667 I79_022667 Fbln1 Fbln1 I79_023010 I79_023010 Ptch1 Ptch1 Irs2 Irs2 I79_024415 I79_024415 I79_025454 I79_025454 Tert Tert Wnt10b Wnt10b Wnt1 Wnt1 Fermt2 Fermt2 Hmx2 Hmx2 Fgf4 Fgf4 Ccne1 Ccne1 Cxcl1 Cxcl1 I79_016814 I79_016814 Sfn Sfn Kdf1 Kdf1 Npm3 Npm3 I79_015616 I79_015616 I79_015181 I79_015181 Gli3 Gli3 Rarg Rarg Wnt11 Wnt11 I79_013817 I79_013817 Snai2 Snai2 Prrx1 Prrx1 Nf2 Nf2 Pdcd2 Pdcd2 I79_012384 I79_012384 I79_011832 I79_011832 Hdac5 Hdac5 Hmgb2 Hmgb2 Pim1 Pim1 I79_010901 I79_010901 Ngf Ngf
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Septin4Septin-4; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (204 aa)
Kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (750 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
Cd109CD109 antigen. (1443 aa)
VegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
MplThrombopoietin receptor. (647 aa)
I79_009043Microprocessor complex subunit DGCR8. (140 aa)
I79_009041Microprocessor complex subunit DGCR8. (630 aa)
Taf4bTranscription initiation factor TFIID subunit 4B. (571 aa)
Hoxa3Homeobox protein Hox-A3. (286 aa)
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (203 aa)
NfibNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
Runx2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
Atxn1lAtaxin-1-like. (688 aa)
I79_007190Protein argonaute-3. (318 aa)
I79_007189Protein argonaute-3. (202 aa)
Ncoa3Nuclear receptor coactivator 3. (1211 aa)
I79_006792DUF1518 domain-containing protein. (200 aa)
HnrnpuHeterogeneous nuclear ribonucleoprotein U. (512 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
I79_006225Sonic hedgehog protein. (226 aa)
I79_005638Epithelial cell adhesion molecule. (240 aa)
Irf6Interferon regulatory factor 6. (467 aa)
Zfp36l1Butyrate response factor 1. (338 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
I79_002659High mobility group protein HMGI-C. (103 aa)
I79_002496Nuclear receptor subfamily 2 group E member 1. (323 aa)
Cdkn2cCyclin-dependent kinase 4 inhibitor C. (168 aa)
I79_001871Transcription factor Ovo-like 2. (213 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
I79_00148465 kDa Yes-associated protein. (257 aa)
Tbx3T-box transcription factor TBX3. (709 aa)
I79_001046Neurofibromin. (2164 aa)
I79_000973Transcription factor SOX-10. (360 aa)
Tp63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
I79_000445Fermitin family-like 1. (641 aa)
I79_019149Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Sox18Transcription factor SOX-18. (377 aa)
Tial1Nucleolysin TIAR. (353 aa)
I79_021808Putative transcription factor Ovo-like 1. (131 aa)
I79_022034Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
I79_022667Fibulin-1. (628 aa)
Fbln1Fibulin-1. (156 aa)
I79_023010Latent-transforming growth factor beta-binding protein 3. (624 aa)
Ptch1Protein patched-like 1. (1114 aa)
Irs2Insulin receptor substrate 2. (465 aa)
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
Wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Fermt2Fermitin family-like 2. (575 aa)
Hmx2Homeobox protein HMX2. (316 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (291 aa)
Cxcl1C-X-C motif chemokine. (101 aa)
I79_016814Short stature homeobox protein 2. (194 aa)
Sfn14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
Kdf1Uncharacterized protein C1orf172-like. (397 aa)
Npm3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
I79_015616Interferon-induced, double-stranded RNA-activated protein kinase. (180 aa)
I79_01518114-3-3 protein sigma; Belongs to the 14-3-3 family. (249 aa)
Gli3Zinc finger protein GLI3. (1582 aa)
RargRetinoic acid receptor gamma. (458 aa)
Wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
I79_013817NAD-dependent deacetylase sirtuin-6. (334 aa)
Snai2Zinc finger protein SNAI2-like protein. (268 aa)
Prrx1Paired mesoderm homeobox protein 1. (198 aa)
Nf2Merlin-like protein. (596 aa)
Pdcd2Programmed cell death protein 2. (708 aa)
I79_012384Leukocyte common antigen. (962 aa)
I79_011832NEDD4-binding protein 2-like 2. (1058 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
Hmgb2High mobility group protein B2. (159 aa)
Pim1Proto-oncogene serine/threonine-protein kinase Pim-1. (250 aa)
I79_010901Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (584 aa)
NgfBeta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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