(98 nodes) Positive regulation of canonical Wnt signaling pathway network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	I79_011753	Abnormal spindle-like microcephaly-associated protein-like. (416 aa)
	Aspm	Abnormal spindle-like microcephaly-associated protein-like. (1831 aa)
	I79_012144	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (2171 aa)
	Wnk2	Serine/threonine-protein kinase WNK2. (1008 aa)
	I79_021835	Leucine-rich repeat serine/threonine-protein kinase 2. (354 aa)
	I79_021836	Leucine-rich repeat serine/threonine-protein kinase 2. (1184 aa)
	I79_021837	Leucine-rich repeat serine/threonine-protein kinase 2. (441 aa)
	Caprin2	Caprin-2. (364 aa)
	I79_021911	Casein kinase I isoform epsilon. (370 aa)
	Amer1	Protein FAM123B. (1113 aa)
	I79_022628	Ubiquitin carboxyl-terminal hydrolase 34. (800 aa)
	I79_022994	Dapper-like 1. (530 aa)
	Dkk2	Dickkopf-related protein 2. (149 aa)
	Ttc21b	Tetratricopeptide repeat protein 21B. (1315 aa)
	I79_013516	Transmembrane protein 198. (327 aa)
	Dapk3	Death-associated protein kinase 3. (530 aa)
	Bambi	BMP and activin membrane-bound inhibitor-like. (218 aa)
	Fam53b	Protein FAM53B. (423 aa)
	Usp47	Ubiquitin carboxyl-terminal hydrolase 47. (754 aa)
	Wls	Integral membrane protein GPR177. (166 aa)
	I79_015617	Casein kinase I isoform gamma-1. (206 aa)
	I79_016051	Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (777 aa)
	I79_016223	Tyrosine-protein kinase-like 7. (98 aa)
	I79_016567	Zinc finger E-box-binding homeobox 2. (1282 aa)
	Trpm4	Transient receptor potential cation channel subfamily M member 4. (315 aa)
	Rnf146	RING finger protein 146. (357 aa)
	I79_018023	Ectodysplasin-A; Belongs to the tumor necrosis factor family. (192 aa)
	I79_018445	F-box-like/WD repeat-containing protein TBL1XR1. (429 aa)
	Tmem198	Transmembrane protein 198. (360 aa)
	Lgr4	Leucine-rich repeat-containing G-protein coupled receptor 4. (231 aa)
	Wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	Usp34	Ubiquitin carboxyl-terminal hydrolase 34. (1095 aa)
	Mylk3	Vacuolar protein sorting-associated protein 35. (1427 aa)
	Kank1	KN motif and ankyrin repeat domain-containing protein 1. (1359 aa)
	Fgfr2	Fibroblast growth factor receptor 2. (659 aa)
	Hhex	Hematopoietically-expressed homeobox protein Hhex. (98 aa)
	I79_025482	Nuclear factor NF-kappa-B p105 subunit. (144 aa)
	Nfkb1	Nuclear factor NF-kappa-B p105 subunit. (509 aa)
	Rspo3	R-spondin-3. (81 aa)
	I79_026084	GSK3-beta interaction protein. (80 aa)
	I79_012685	Caprin-2. (215 aa)
	I79_012686	Caprin-2. (132 aa)
	Xiap	Baculoviral IAP repeat-containing protein 4. (441 aa)
	Jrk	Jerky protein. (560 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	I79_005909	Peptidyl-prolyl cis-trans isomerase. (242 aa)
	Tnks	Poly [ADP-ribose] polymerase. (897 aa)
	I79_005573	Secreted frizzled-related protein 2. (268 aa)
	Lrrk1	Leucine-rich repeat serine/threonine-protein kinase 1. (396 aa)
	Csnk1g1	Casein kinase I isoform gamma-1; Belongs to the protein kinase superfamily. (459 aa)
	Lgr5	Leucine-rich repeat-containing G-protein coupled receptor 5. (555 aa)
	I79_004948	Poly [ADP-ribose] polymerase. (1080 aa)
	Tmem9	Transmembrane protein 9. (183 aa)
	Adgra2	Putative G-protein coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1048 aa)
	Usp8	Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1075 aa)
	Rnf220	E3 ubiquitin-protein ligase. (254 aa)
	I79_002988	RING finger protein 220. (317 aa)
	Ctdnep1	Serine/threonine-protein phosphatase dullard. (210 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Csnk1d	Casein kinase I isoform delta. (358 aa)
	Sfrp4	Secreted frizzled-related protein 4. (348 aa)
	Ppm1b	Protein phosphatase 1B. (479 aa)
	Ccar2	Protein KIAA1967-like. (916 aa)
	I79_001484	65 kDa Yes-associated protein. (257 aa)
	Nle1	Notchless protein-like 1. (297 aa)
	Atp6ap2	Renin receptor. (300 aa)
	ilk	Integrin-linked protein kinase. (452 aa)
	H671_1g3307	Disheveled-associated activator of morphogenesis 2. (967 aa)
	I79_020843	Reversion-inducing cysteine-rich protein with Kazal motifs. (107 aa)
	Reck	Reversion-inducing cysteine-rich protein with Kazal motifs. (714 aa)
	Ppm1a	Protein phosphatase 1A. (382 aa)
	Rbpj	Recombining binding protein suppressor of hairless-like protein. (486 aa)
	I79_021564	Pro-epidermal growth factor. (699 aa)
	Sema5a	Semaphorin-5A. (1046 aa)
	Wnk1	Serine/threonine-protein kinase WNK1. (1516 aa)
	I79_006679	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
	Smad3	Mothers against decapentaplegic homolog. (363 aa)
	Sulf2	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (875 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Fzd9	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (439 aa)
	Dlx5	Homeobox protein DLX-5. (289 aa)
	Rspo1	R-spondin-1. (262 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	I79_009259	Casein kinase I isoform gamma-2. (287 aa)
	Prdm15	PR domain zinc finger protein 15. (1148 aa)
	I79_009708	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (332 aa)
	Gid8	Protein C20orf11-like. (228 aa)
	Sfrp1	Secreted frizzled-related protein 1. (104 aa)
	I79_010136	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
	Map3k1	Mitogen-activated protein kinase kinase kinase 1. (1340 aa)
	Ruvbl1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	Col1a1	Collagen alpha-1(I) chain. (355 aa)
	Fgfr3	Fibroblast growth factor receptor 3. (319 aa)
	I79_011134	Casein kinase I isoform gamma-3. (102 aa)
	Csnk1g3	Casein kinase I isoform gamma-3. (196 aa)
	Cdh3	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
	Ubr5	E3 ubiquitin-protein ligase UBR5. (380 aa)
	I79_011384	E3 ubiquitin-protein ligase UBR5. (295 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Amer1	I79_010136	G3IE81	G3HHN2	Protein FAM123B.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.451
Aspm	I79_011753	G3HM10	G3HM09	Abnormal spindle-like microcephaly-associated protein-like.	Abnormal spindle-like microcephaly-associated protein-like.	0.928
Bambi	Fzd9	G3HT30	G3HA15	BMP and activin membrane-bound inhibitor-like.	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family.	0.914
Bambi	Ppm1a	G3HT30	G3IBM7	BMP and activin membrane-bound inhibitor-like.	Protein phosphatase 1A.	0.483
Bambi	Sfrp4	G3HT30	G3GV63	BMP and activin membrane-bound inhibitor-like.	Secreted frizzled-related protein 4.	0.445
Bambi	Smad3	G3HT30	G3H8N9	BMP and activin membrane-bound inhibitor-like.	Mothers against decapentaplegic homolog.	0.524
Bambi	Tgfb1	G3HT30	G3IA12	BMP and activin membrane-bound inhibitor-like.	Transforming growth factor beta-1.	0.696
Caprin2	I79_012685	G3HPH2	G3HPH3	Caprin-2.	Caprin-2.	0.924
Caprin2	I79_012686	G3HPH2	G3HPH4	Caprin-2.	Caprin-2.	0.889
Cav1	Col1a1	G3H9I8	G3HJR4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Collagen alpha-1(I) chain.	0.447
Cav1	I79_008941	G3H9I8	G3HEF7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein-tyrosine kinase.	0.634
Cav1	I79_010136	G3H9I8	G3HHN2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.595
Cav1	I79_021564	G3H9I8	G3ID03	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Pro-epidermal growth factor.	0.427
Cav1	Smad3	G3H9I8	G3H8N9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Mothers against decapentaplegic homolog.	0.477
Cav1	Src	G3H9I8	G3GXX7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.985
Cdh3	I79_008941	G3HKU9	G3HEF7	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins.	Receptor protein-tyrosine kinase.	0.623
Cdh3	I79_016567	G3HKU9	G3HZQ8	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins.	Zinc finger E-box-binding homeobox 2.	0.402
Col1a1	Cav1	G3HJR4	G3H9I8	Collagen alpha-1(I) chain.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.447
Col1a1	Fgfr3	G3HJR4	G3HK77	Collagen alpha-1(I) chain.	Fibroblast growth factor receptor 3.	0.655
Col1a1	Smad3	G3HJR4	G3H8N9	Collagen alpha-1(I) chain.	Mothers against decapentaplegic homolog.	0.587