STRINGSTRING
I79_000658 I79_000658 Nos1 Nos1 SIRT4 SIRT4 Ndufaf2 Ndufaf2 Ghrl Ghrl Rptor Rptor Jagn1 Jagn1 Madd Madd Ptpmt1 Ptpmt1 Lep Lep Fkbp1b Fkbp1b Psmd9 Psmd9 Hadh Hadh I79_004244 I79_004244 Drd2 Drd2 I79_004403 I79_004403 I79_004628 I79_004628 Crhbp Crhbp I79_005107 I79_005107 I79_005742 I79_005742 Sytl4 Sytl4 Ghsr Ghsr I79_006005 I79_006005 CgPICR_019210 CgPICR_019210 Pfkl Pfkl I79_006981 I79_006981 I79_007339 I79_007339 Sirt1 Sirt1 I79_007441 I79_007441 ENY2 ENY2 I79_008584 I79_008584 Kcnb1 Kcnb1 I79_009077 I79_009077 Midn Midn Vsnl1 Vsnl1 Sfrp1 Sfrp1 I79_010155 I79_010155 I79_010194 I79_010194 Cartpt Cartpt Pde1c Pde1c Crhr2 Crhr2 I79_012722 I79_012722 I79_013556 I79_013556 I79_013773 I79_013773 Chga Chga Npff Npff PPARG PPARG Mtnr1a Mtnr1a I79_015904 I79_015904 Kcnq1 Kcnq1 Foxo1 Foxo1 I79_017352 I79_017352 Pim3 Pim3 I79_017834 I79_017834 Fam3d Fam3d Anxa5 Anxa5 Adra2a Adra2a Rest Rest Ucp3 Ucp3 Irs1 Irs1 I79_022367 I79_022367 I79_022515 I79_022515 I79_023475 I79_023475 I79_023892 I79_023892 I79_025031 I79_025031 I79_025512 I79_025512
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_000658Kalirin. (2681 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (255 aa)
Ndufaf2Mimitin, mitochondrial. (168 aa)
GhrlAppetite-regulating hormone. (100 aa)
RptorRegulatory-associated protein of mTOR. (1331 aa)
Jagn1Protein jagunal-like 1. (183 aa)
MaddMAP kinase-activating death domain protein. (1585 aa)
Ptpmt1Protein-tyrosine phosphatase mitochondrial 1. (126 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Fkbp1bPeptidylprolyl isomerase. (143 aa)
Psmd926S proteasome non-ATPase regulatory subunit 9. (222 aa)
HadhHydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (116 aa)
I79_004244Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
Drd2D(2) dopamine receptor. (274 aa)
I79_004403D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (187 aa)
I79_004628Phosphodiesterase. (786 aa)
CrhbpCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
I79_005107Phosphodiesterase. (620 aa)
I79_005742Synaptotagmin-like protein 4. (474 aa)
Sytl4Synaptotagmin-like protein 4. (150 aa)
GhsrGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
I79_006005Melatonin receptor type 1B; Belongs to the G-protein coupled receptor 1 family. (240 aa)
CgPICR_019210Melatonin receptor type 1B. (112 aa)
Pfkl6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (745 aa)
I79_006981G-protein coupled receptor 120. (318 aa)
I79_007339Protein NOV-like. (256 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
I79_007441Syntaxin-binding protein 5-like. (435 aa)
ENY2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (131 aa)
I79_008584Krueppel-like factor 7. (301 aa)
Kcnb1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (706 aa)
I79_009077Potassium voltage-gated channel subfamily B member 1. (188 aa)
MidnMidnolin. (317 aa)
Vsnl1Visinin-like protein 1. (191 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
I79_010155Sterol regulatory element-binding protein 1. (1050 aa)
I79_010194Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (387 aa)
CartptCocaine-and amphetamine-regulated transcript protein. (112 aa)
Pde1cPhosphodiesterase. (583 aa)
Crhr2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (396 aa)
I79_012722Major urinary protein 5; Belongs to the calycin superfamily. Lipocalin family. (153 aa)
I79_013556Fibrillin-1. (2698 aa)
I79_013773cGMP-inhibited 3',5'-cyclic phosphodiesterase B. (265 aa)
ChgaChromogranin-A. (434 aa)
NpffFMRFamide-related peptides. (132 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Mtnr1aMelatonin receptor type 1A; Belongs to the G-protein coupled receptor 1 family. (353 aa)
I79_015904Potassium voltage-gated channel subfamily KQT member 1. (216 aa)
Kcnq1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (308 aa)
Foxo1Forkhead box protein O1. (469 aa)
I79_017352ATP-binding cassette transporter sub-family C member 8. (2352 aa)
Pim3Serine/threonine-protein kinase Pim-3. (89 aa)
I79_017834Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (273 aa)
Fam3dProtein FAM3D. (185 aa)
Anxa5Annexin. (321 aa)
Adra2aAlpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
RestRE1-silencing transcription factor. (1047 aa)
Ucp3Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (650 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
I79_022367Nucleobindin-2. (420 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
I79_023892TBC1 domain family member 1. (817 aa)
I79_025031TBC1 domain family member 1. (232 aa)
I79_025512Urotensin-2. (88 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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