STRINGSTRING
Spry4 Spry4 Ptpn1 Ptpn1 I79_009115 I79_009115 I79_009116 I79_009116 Fstl3 Fstl3 I79_009306 I79_009306 H671_1g1417 H671_1g1417 Sfrp1 Sfrp1 Thbs1 Thbs1 I79_010224 I79_010224 Hhex Hhex I79_025170 I79_025170 I79_024593 I79_024593 I79_023937 I79_023937 Tcf7l2 Tcf7l2 I79_023359 I79_023359 I79_022645 I79_022645 Tnfaip6 Tnfaip6 Grem1 Grem1 Ppm1a Ppm1a I79_020974 I79_020974 I79_020783 I79_020783 Chrdl2 Chrdl2 I79_019878 I79_019878 Prdm14 Prdm14 I79_019792 I79_019792 I79_019293 I79_019293 Fuz Fuz Lemd2 Lemd2 Wnt1 Wnt1 Agtr2 Agtr2 I79_018432 I79_018432 Xdh Xdh H671_4g11668 H671_4g11668 I79_017780 I79_017780 Ski Ski Gdf3 Gdf3 Ofd1 Ofd1 I79_016483 I79_016483 Twsg1 Twsg1 Smurf1 Smurf1 Vwc2 Vwc2 Sostdc1 Sostdc1 Dab2ip Dab2ip H671_3g10913 H671_3g10913 Vwc2l Vwc2l PPARG PPARG Crim1 Crim1 I79_014724 I79_014724 Cflar Cflar Smad7 Smad7 Nbl1 Nbl1 Spry1 Spry1 Bambi Bambi Skil Skil Wnt4 Wnt4 Adamts12 Adamts12 I79_010524 I79_010524 Dcn Dcn Ngfr Ngfr Sema6a Sema6a Atp2b4 Atp2b4 I79_013076 I79_013076 Fzd1 Fzd1 Sost Sost I79_012498 I79_012498 I79_025972 I79_025972 I79_025933 I79_025933 Sorl1 Sorl1 I79_013556 I79_013556 Gata3 Gata3 I79_000157 I79_000157 I79_000592 I79_000592 I79_001239 I79_001239 Dlx1 Dlx1 Wnt5a Wnt5a Agt Agt Hgs Hgs Emilin1 Emilin1 Msrb3 Msrb3 Creb3l1 Creb3l1 Pdcd6 Pdcd6 Nog Nog Adgra2 Adgra2 I79_004532 I79_004532 Gpc1 Gpc1 I79_005573 I79_005573 Grem2 Grem2 Dkk1 Dkk1 I79_006745 I79_006745 Smad6 Smad6 Shisa2 Shisa2 Sulf2 Sulf2 Tob1 Tob1 Cer1 Cer1 I79_008298 I79_008298 IL12B IL12B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Spry4Protein sprouty-like 4. (100 aa)
Ptpn1Tyrosine-protein phosphatase non-receptor type 1. (335 aa)
I79_009115Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
I79_009116Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
Fstl3Follistatin-related protein 3. (147 aa)
I79_009306Receptor-type tyrosine-protein phosphatase F. (1838 aa)
H671_1g1417Spartin isoform 2. (616 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Thbs1Thrombospondin-1. (533 aa)
I79_010224BMP-binding endothelial regulator protein. (371 aa)
HhexHematopoietically-expressed homeobox protein Hhex. (98 aa)
I79_025170Slit-like 2 protein. (345 aa)
I79_024593Uncharacterized protein. (194 aa)
I79_023937Sortilin-related receptor. (88 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
I79_023359Transmembrane protease, serine 6. (67 aa)
I79_022645Programmed cell death protein 6. (224 aa)
Tnfaip6Tumor necrosis factor-inducible gene 6 protein. (275 aa)
Grem1Gremlin-1. (117 aa)
Ppm1aProtein phosphatase 1A. (382 aa)
I79_020974Serine protease HTRA1. (268 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
Chrdl2Chordin-like protein 2. (345 aa)
I79_019878Sortilin. (1038 aa)
Prdm14PR domain zinc finger protein 14. (564 aa)
I79_019792Chondromodulin-1. (245 aa)
I79_019293Protein fuzzy-like. (60 aa)
FuzProtein fuzzy-like. (365 aa)
Lemd2LEM domain-containing protein 2. (271 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Agtr2Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
I79_018432Homeobox protein NANOG. (490 aa)
XdhXanthine dehydrogenase/oxidase. (1332 aa)
H671_4g11668Chordin. (842 aa)
I79_017780Extracellular sulfatase Sulf-1. (787 aa)
SkiSki oncogene. (636 aa)
Gdf3Growth/differentiation factor 3. (361 aa)
Ofd1Oral-facial-digital syndrome 1 protein-like. (957 aa)
I79_016483Chordin-like protein 1. (427 aa)
Twsg1Twisted gastrulation protein-like 1. (222 aa)
Smurf1E3 ubiquitin-protein ligase SMURF1. (303 aa)
Vwc2Brorin. (221 aa)
Sostdc1Sclerostin domain-containing protein 1. (193 aa)
Dab2ipDisabled-like 2-interacting protein. (1065 aa)
H671_3g10913Protein sprouty-like 4. (82 aa)
Vwc2lVon Willebrand factor C domain-containing protein 2-like. (179 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Crim1Cysteine-rich motor neuron 1 protein. (556 aa)
I79_014724Cysteine-rich motor neuron 1 protein. (344 aa)
CflarCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (484 aa)
Smad7Mothers against decapentaplegic-like 7. (256 aa)
Nbl1Neuroblastoma suppressor of tumorigenicity 1-like protein. (178 aa)
Spry1Protein sprouty-like 1. (313 aa)
BambiBMP and activin membrane-bound inhibitor-like. (218 aa)
SkilSki-like protein. (677 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
Adamts12A disintegrin and metalloproteinase with thrombospondin motifs 12. (171 aa)
I79_010524A disintegrin and metalloproteinase with thrombospondin motifs 12. (1148 aa)
DcnDecorin; May affect the rate of fibrils formation. (362 aa)
NgfrTumor necrosis factor receptor superfamily member 16. (429 aa)
Sema6aSemaphorin-6A; Belongs to the semaphorin family. (503 aa)
Atp2b4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1189 aa)
I79_013076E3 ubiquitin-protein ligase TRIM33. (910 aa)
Fzd1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (514 aa)
SostSclerostin. (213 aa)
I79_012498Semaphorin-6A. (305 aa)
I79_025972Hepatocyte growth factor-regulated tyrosine kinase substrate. (147 aa)
I79_025933Programmed cell death protein 6. (60 aa)
Sorl1Sortilin-related receptor. (223 aa)
I79_013556Fibrillin-1. (2698 aa)
Gata3Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
I79_000157E3 ubiquitin-protein ligase NEDD4. (1032 aa)
I79_000592Peripheral plasma membrane protein CASK; Belongs to the MAGUK family. (742 aa)
I79_001239Low-density lipoprotein receptor-related protein 2. (4664 aa)
Dlx1Homeobox protein DLX-1. (255 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
HgsHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
Emilin1EMILIN-1. (1017 aa)
Msrb3Inner nuclear membrane protein Man1. (479 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (475 aa)
Pdcd6Programmed cell death protein 6. (83 aa)
NogNoggin. (117 aa)
Adgra2Putative G-protein coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1048 aa)
I79_004532Hemojuvelin. (597 aa)
Gpc1Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (781 aa)
I79_005573Secreted frizzled-related protein 2. (268 aa)
Grem2Gremlin. (168 aa)
Dkk1Dickkopf-related protein 1. (269 aa)
I79_006745Mothers against decapentaplegic-like 6. (71 aa)
Smad6Mothers against decapentaplegic-like 6. (174 aa)
Shisa2Protein shisa-2-like. (220 aa)
Sulf2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (875 aa)
Tob1Protein Tob1-like protein. (350 aa)
Cer1Cerberus. (272 aa)
I79_008298E3 ubiquitin-protein ligase SMURF2. (571 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.