(49 nodes) Regulation of plasma lipoprotein particle levels network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (492 aa)
	Apoa1	Apolipoprotein A-I. (264 aa)
	Ehd1	EH domain-containing protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (398 aa)
	Pla2g3	Group 3 secretory phospholipase A2. (398 aa)
	Apom	Apolipoprotein M. (90 aa)
	I79_016465	Apolipoprotein M. (56 aa)
	Washc1	WAS protein family-like 1. (497 aa)
	Adipoq	Adiponectin. (248 aa)
	Scarb1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	Dgat1	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (327 aa)
	I79_015159	O-acyltransferase. (578 aa)
	I79_015046	Low-density lipoprotein receptor. (160 aa)
	Dgat2	Diacylglycerol O-acyltransferase 2. (388 aa)
	Pla2g5	Phospholipase A(2). (137 aa)
	Pla2g2e	Phospholipase A(2). (154 aa)
	Apoa2	Apolipoprotein A-II-like protein. (101 aa)
	Lipg	Endothelial lipase. (543 aa)
	Apoc2	Apolipoprotein C-II. (100 aa)
	Apoe	Apolipoprotein E. (313 aa)
	Mfsd2a	Major facilitator superfamily domain-containing protein 2. (527 aa)
	I79_011940	Platelet glycoprotein 4; Belongs to the CD36 family. (348 aa)
	Abcg1	ATP-binding cassette sub-family G member 1. (647 aa)
	Lcat	Phosphatidylcholine-sterol acyltransferase. (183 aa)
	Pla2g12b	Group XIIB secretory phospholipase A2-like protein. (195 aa)
	Apoc3	Apolipoprotein C-III. (76 aa)
	I79_010135	ADP-ribosylation factor 1. (72 aa)
	I79_009991	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (152 aa)
	Abca7	ATP-binding cassette sub-family A member 7. (408 aa)
	Plagl2	Zinc finger protein PLAGL2. (496 aa)
	Commd1	COMM domain-containing protein 1. (188 aa)
	I79_007908	Lipase maturation factor 1. (168 aa)
	Lmf1	Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (355 aa)
	Pltp	Phospholipid transfer protein. (493 aa)
	Acsl3	Long-chain-fatty-acid--CoA ligase 3. (709 aa)
	Soat2	O-acyltransferase. (521 aa)
	I79_025297	Very low-density lipoprotein receptor. (558 aa)
	LDLR	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
	I79_006760	ADP-ribosylation factor 1. (168 aa)
	Lpl	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (450 aa)
	Fech	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (348 aa)
	Apob	Apolipoprotein B-100. (3537 aa)
	I79_003342	Apolipoprotein B-100. (946 aa)
	I79_003188	Macrophage scavenger receptor types I and II. (266 aa)
	Pla2g10	Phospholipase A(2). (140 aa)
	I79_001429	Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (500 aa)
	Abca1	ATP-binding cassette sub-family A member 1. (2261 aa)
	Lipc	Hepatic triacylglycerol lipase. (470 aa)
	Apoa5	Apolipoprotein A-V. (363 aa)
	CgPICR_005982	Apolipoprotein A-IV. (230 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abca1	Abcg1	G3GTZ6	G3HLD6	ATP-binding cassette sub-family A member 1.	ATP-binding cassette sub-family G member 1.	0.500
Abca1	Apoa1	G3GTZ6	G3I7Q1	ATP-binding cassette sub-family A member 1.	Apolipoprotein A-I.	0.945
Abca1	Apoa2	G3GTZ6	G3HTY7	ATP-binding cassette sub-family A member 1.	Apolipoprotein A-II-like protein.	0.621
Abca1	Apob	G3GTZ6	G3GZQ0	ATP-binding cassette sub-family A member 1.	Apolipoprotein B-100.	0.782
Abca1	Apoc3	G3GTZ6	G3I7Q2	ATP-binding cassette sub-family A member 1.	Apolipoprotein C-III.	0.454
Abca1	Apoe	G3GTZ6	G3HPC9	ATP-binding cassette sub-family A member 1.	Apolipoprotein E.	0.882
Abca1	CETP	G3GTZ6	G3HIK4	ATP-binding cassette sub-family A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.878
Abca1	I79_011940	G3GTZ6	G3HMH7	ATP-binding cassette sub-family A member 1.	Platelet glycoprotein 4; Belongs to the CD36 family.	0.513
Abca1	Lcat	G3GTZ6	G3HKW5	ATP-binding cassette sub-family A member 1.	Phosphatidylcholine-sterol acyltransferase.	0.776
Abca1	Lipc	G3GTZ6	G3GRM1	ATP-binding cassette sub-family A member 1.	Hepatic triacylglycerol lipase.	0.509
Abca1	Lipg	G3GTZ6	G3HQJ0	ATP-binding cassette sub-family A member 1.	Endothelial lipase.	0.468
Abca1	Lpl	G3GTZ6	G3H6V7	ATP-binding cassette sub-family A member 1.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.480
Abca1	Pltp	G3GTZ6	G3H8V4	ATP-binding cassette sub-family A member 1.	Phospholipid transfer protein.	0.722
Abca1	Scarb1	G3GTZ6	G3HX53	ATP-binding cassette sub-family A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.696
Abca7	Apoe	G3HF57	G3HPC9	ATP-binding cassette sub-family A member 7.	Apolipoprotein E.	0.414
Abcg1	Abca1	G3HLD6	G3GTZ6	ATP-binding cassette sub-family G member 1.	ATP-binding cassette sub-family A member 1.	0.500
Abcg1	Apoa2	G3HLD6	G3HTY7	ATP-binding cassette sub-family G member 1.	Apolipoprotein A-II-like protein.	0.499
Abcg1	Apob	G3HLD6	G3GZQ0	ATP-binding cassette sub-family G member 1.	Apolipoprotein B-100.	0.642
Abcg1	Apoe	G3HLD6	G3HPC9	ATP-binding cassette sub-family G member 1.	Apolipoprotein E.	0.816
Abcg1	CETP	G3HLD6	G3HIK4	ATP-binding cassette sub-family G member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.748