STRINGSTRING
Mknk1 Mknk1 Casp2 Casp2 Ngf Ngf Cx3cl1 Cx3cl1 Kitlg Kitlg Itgav Itgav Bcl2l1 Bcl2l1 Bcl2 Bcl2 Gsk3b Gsk3b Eya2 Eya2 Igf1 Igf1 Bok Bok Mcl1 Mcl1 I79_003468 I79_003468 I79_012727 I79_012727 Foxo3 Foxo3 I79_023808 I79_023808 Bag3 Bag3 Lcn2 Lcn2 Bcl2a1 Bcl2a1 Bcl2l10 Bcl2l10 Bak1 Bak1 I79_001046 I79_001046 IL1B IL1B Gsk3a Gsk3a Moap1 Moap1 IL2 IL2 Ikzf4 Ikzf4 Bcl2l2 Bcl2l2 Fas Fas H671_3g9857 H671_3g9857 Fadd Fadd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mknk1MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (415 aa)
Casp2Caspase-2; Belongs to the peptidase C14A family. (421 aa)
NgfBeta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
Cx3cl1Fractalkine. (335 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ItgavIntegrin alpha-V; Belongs to the integrin alpha chain family. (944 aa)
Bcl2l1Bcl-2-like protein 1. (233 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
Eya2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (550 aa)
Igf1Insulin-like growth factor I. (75 aa)
BokBcl-2-related ovarian killer protein. (213 aa)
Mcl1Putative induced myeloid leukemia cell differentiation protein Mcl-1 like protein. (120 aa)
I79_003468Bcl-2-like protein 11. (141 aa)
I79_012727Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (441 aa)
Foxo3Forkhead box protein O3. (672 aa)
I79_023808Induced myeloid leukemia cell differentiation protein Mcl-1-like. (118 aa)
Bag3BAG family molecular chaperone regulator 3. (571 aa)
Lcn2Neutrophil gelatinase-associated lipocalin; Belongs to the calycin superfamily. Lipocalin family. (229 aa)
Bcl2a1Bcl-2-related protein A1. (203 aa)
Bcl2l10Bcl-2-like protein 10. (113 aa)
Bak1Bcl-2-likeous antagonist/killer. (209 aa)
I79_001046Neurofibromin. (2164 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Gsk3aGlycogen synthase kinase-3 alpha. (653 aa)
Moap1Modulator of apoptosis 1. (353 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Ikzf4Receptor protein-tyrosine kinase. (1902 aa)
Bcl2l2Bcl-2-like protein 2. (193 aa)
FasTumor necrosis factor receptor superfamily member 6. (124 aa)
H671_3g9857Tumor necrosis factor receptor superfamily member 6-like protein. (170 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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