STRINGSTRING
Fadd Fadd Ripk2 Ripk2 Nlrc4 Nlrc4 Bak1 Bak1 Casp8 Casp8 I79_001600 I79_001600 I79_001975 I79_001975 I79_004417 I79_004417 Cideb Cideb I79_017669 I79_017669 I79_018057 I79_018057 I79_018344 I79_018344 I79_019425 I79_019425 I79_020089 I79_020089 Nlrp6 Nlrp6 I79_017529 I79_017529 Lgmn Lgmn Tbc1d10a Tbc1d10a I79_016311 I79_016311 I79_012811 I79_012811
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
Nlrc4NLR family CARD domain-containing protein 4. (857 aa)
Bak1Bcl-2-likeous antagonist/killer. (209 aa)
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
I79_001975P53 apoptosis effector related to PMP-22. (121 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CidebCell death activator CIDE-B. (219 aa)
I79_017669Apoptotic protease-activating factor 1. (434 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
I79_018344Cytoplasmic FMR1-interacting protein 2. (1033 aa)
I79_019425Apoptosis-associated speck-like protein containing a CARD. (192 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
Nlrp6NACHT, LRR and PYD domains-containing protein 6. (995 aa)
I79_017529Apoptotic protease-activating factor 1. (444 aa)
LgmnLegumain. (438 aa)
Tbc1d10aTBC1 domain family member 10A. (272 aa)
I79_016311PRKC apoptosis WT1 regulator protein. (214 aa)
I79_012811Aspartyl/asparaginyl beta-hydroxylase. (564 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.