(35 nodes) Regulation of neuroblast proliferation network (Cricetulus griseus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_021837	Leucine-rich repeat serine/threonine-protein kinase 2. (441 aa)
	I79_001046	Neurofibromin. (2164 aa)
	I79_002288	Disrupted in schizophrenia 1-like. (648 aa)
	I79_002496	Nuclear receptor subfamily 2 group E member 1. (323 aa)
	Kctd11	BTB/POZ domain-containing protein KCTD11. (232 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Pax6	Paired box protein Pax-6. (544 aa)
	Fzd3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	Drd2	D(2) dopamine receptor. (274 aa)
	I79_004403	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (187 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	Znf335	Zinc finger protein 335. (1171 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Ptn	Pleiotrophin. (168 aa)
	Smarcd3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (300 aa)
	Vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
	Cx3cl1	Fractalkine. (335 aa)
	Kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (750 aa)
	Sox2	Transcription factor SOX-2. (273 aa)
	I79_011753	Abnormal spindle-like microcephaly-associated protein-like. (416 aa)
	Aspm	Abnormal spindle-like microcephaly-associated protein-like. (1831 aa)
	I79_012741	Kinesin-associated protein 3. (610 aa)
	I79_012789	WD repeat-containing protein 62. (724 aa)
	Cx3cr1	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	Hif1a	Hypoxia-inducible factor 1 alpha. (820 aa)
	Itgb1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	Sox10	Transcription factor SOX-10. (466 aa)
	I79_020343	Cardiotrophin-2. (229 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	I79_021577	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
	I79_021835	Leucine-rich repeat serine/threonine-protein kinase 2. (354 aa)
	I79_021836	Leucine-rich repeat serine/threonine-protein kinase 2. (1184 aa)
	Prox1	Prospero homeobox protein 1. (738 aa)
	Dct	L-dopachrome tautomerase. (517 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aspm	I79_001046	G3HM10	G3GTQ9	Abnormal spindle-like microcephaly-associated protein-like.	Neurofibromin.	0.435
Aspm	I79_011753	G3HM10	G3HM09	Abnormal spindle-like microcephaly-associated protein-like.	Abnormal spindle-like microcephaly-associated protein-like.	0.928
Aspm	I79_012789	G3HM10	G3HPR7	Abnormal spindle-like microcephaly-associated protein-like.	WD repeat-containing protein 62.	0.542
Ctnnb1	Fzd3	G3H996	G3H0J5	Catenin beta-1.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.543
Ctnnb1	Hif1a	G3H996	G3HZ04	Catenin beta-1.	Hypoxia-inducible factor 1 alpha.	0.841
Ctnnb1	I79_006225	G3H996	G3H796	Catenin beta-1.	Sonic hedgehog protein.	0.553
Ctnnb1	Itgb1	G3H996	G3HZ55	Catenin beta-1.	Integrin beta; Belongs to the integrin beta chain family.	0.539
Ctnnb1	Kdm1a	G3H996	G3HIN6	Catenin beta-1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.470
Ctnnb1	Smo	G3H996	G3GZ55	Catenin beta-1.	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.460
Ctnnb1	Sox10	G3H996	G3I510	Catenin beta-1.	Transcription factor SOX-10.	0.641
Ctnnb1	Sox2	G3H996	G3HJZ4	Catenin beta-1.	Transcription factor SOX-2.	0.771
Ctnnb1	Tgfb1	G3H996	G3IA12	Catenin beta-1.	Transforming growth factor beta-1.	0.560
Cx3cl1	Cx3cr1	G3HIL2	G3HQW7	Fractalkine.	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.999
Cx3cl1	I79_021577	G3HIL2	G3ID16	Fractalkine.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.497
Cx3cr1	Cx3cl1	G3HQW7	G3HIL2	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Fractalkine.	0.999
Cx3cr1	I79_021577	G3HQW7	G3ID16	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.450
Drd2	I79_002288	G3H2I9	G3GX01	D(2) dopamine receptor.	Disrupted in schizophrenia 1-like.	0.409
Drd2	I79_004403	G3H2I9	G3H2J0	D(2) dopamine receptor.	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.926
Drd2	I79_021577	G3H2I9	G3ID16	D(2) dopamine receptor.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.427
Fzd3	Ctnnb1	G3H0J5	G3H996	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Catenin beta-1.	0.543