STRINGSTRING
Hif1a Hif1a Srf Srf Hdac4 Hdac4 Mrtfa Mrtfa Gata3 Gata3 I79_000092 I79_000092 PPARG PPARG Tead1 Tead1 Smad4 Smad4 Ppard Ppard I79_012419 I79_012419 Stat3 Stat3 Nfatc3 Nfatc3 Ngfr Ngfr Gata2 Gata2 Hdac2 Hdac2 I79_010155 I79_010155 I79_009953 I79_009953 Znf512b Znf512b Egr1 Egr1 Nr3c1 Nr3c1 I79_008527 I79_008527 Nfib Nfib Il10 Il10 Smad1 Smad1 Smad3 Smad3 Smad6 Smad6 I79_006745 I79_006745 Ets1 Ets1 Tgfbr1 Tgfbr1 I79_006254 I79_006254 Smarca4 Smarca4 Klf5 Klf5 I79_003100 I79_003100 Foxo3 Foxo3 Mrtfb Mrtfb Znf512 Znf512 I79_000973 I79_000973 I79_025783 I79_025783 Tert Tert Myc Myc Nfkb1 Nfkb1 I79_025513 I79_025513 I79_025482 I79_025482 I79_025459 I79_025459 I79_025454 I79_025454 I79_025316 I79_025316 I79_024959 I79_024959 I79_024415 I79_024415 Ppara Ppara I79_022390 I79_022390 I79_021938 I79_021938 Rela Rela I79_021093 I79_021093 Klf4 Klf4 Tgfb1 Tgfb1 Rest Rest Nr1h2 Nr1h2 I79_018785 I79_018785 Pdgfb Pdgfb Fosl1 Fosl1 Ctcf Ctcf Tnf Tnf
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
SrfSerum response factor. (361 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
MrtfaMKL/myocardin-like protein 1. (1047 aa)
Gata3Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Tead1Transcriptional enhancer factor TEF-1. (432 aa)
Smad4Mothers against decapentaplegic-like 4. (259 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
I79_012419Zinc finger protein 512. (319 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Nfatc3Nuclear factor of activated T-cells, cytoplasmic 3. (1075 aa)
NgfrTumor necrosis factor receptor superfamily member 16. (429 aa)
Gata2Endothelial transcription factor GATA-2. (480 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
I79_010155Sterol regulatory element-binding protein 1. (1050 aa)
I79_009953Transcription factor AP-1. (72 aa)
Znf512bZinc finger protein 512B. (875 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
Nr3c1Glucocorticoid receptor. (748 aa)
I79_008527Nuclear factor of activated T-cells, cytoplasmic 4. (849 aa)
NfibNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
Il10Interleukin-10. (178 aa)
Smad1Mothers against decapentaplegic-like 1. (232 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
Smad6Mothers against decapentaplegic-like 6. (174 aa)
I79_006745Mothers against decapentaplegic-like 6. (71 aa)
Ets1Protein C-ets-1. (257 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
Smarca4Putative global transcription activator SNF2L4. (1614 aa)
Klf5Krueppel-like factor 5. (366 aa)
I79_003100Myocardin. (371 aa)
Foxo3Forkhead box protein O3. (672 aa)
MrtfbMKL/myocardin-like protein 2. (1069 aa)
Znf512Zinc finger protein 512. (85 aa)
I79_000973Transcription factor SOX-10. (360 aa)
I79_025783Mothers against decapentaplegic-like 1. (97 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
MycMyc proto-oncogene protein. (281 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (509 aa)
I79_025513Mothers against decapentaplegic-like 1. (151 aa)
I79_025482Nuclear factor NF-kappa-B p105 subunit. (144 aa)
I79_025459Mothers against decapentaplegic-like 1. (117 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
I79_025316Mothers against decapentaplegic-like 1. (104 aa)
I79_024959Mothers against decapentaplegic-like 1. (161 aa)
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
PparaPeroxisome proliferator-activated receptor alpha. (393 aa)
I79_022390Peroxisome proliferator-activated receptor alpha. (110 aa)
I79_021938Mothers against decapentaplegic-like 1. (122 aa)
RelaTranscription factor p65. (546 aa)
I79_021093Sterol regulatory element-binding protein 2. (2034 aa)
Klf4Krueppel-like factor 4. (474 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
RestRE1-silencing transcription factor. (1047 aa)
Nr1h2Oxysterols receptor LXR-beta. (445 aa)
I79_018785Retinoic acid receptor alpha. (484 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
Fosl1Fos-related antigen 1. (279 aa)
CtcfTranscriptional repressor CTCF. (734 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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