(50 nodes) Regulation of phospholipid metabolic process network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Abca3	ATP-binding cassette sub-family A member 3. (1704 aa)
	I79_000054	Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (668 aa)
	Gnb3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (227 aa)
	Phb2	Prohibitin-2. (396 aa)
	Prkcd	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (437 aa)
	Scp2	Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
	Mtmr9	Myotubularin-related protein 9. (735 aa)
	Chp1	Calcium-binding protein p22. (195 aa)
	Fabp3	Fatty acid-binding protein, heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (121 aa)
	Slc27a1	Long-chain fatty acid transport protein 1. (218 aa)
	I79_005331	Receptor tyrosine-protein kinase erbB-4. (480 aa)
	Mtmr2	Myotubularin-related protein 2. (572 aa)
	I79_006760	ADP-ribosylation factor 1. (168 aa)
	I79_007089	Receptor tyrosine-protein kinase erbB-4. (225 aa)
	LDLR	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
	I79_007090	Receptor tyrosine-protein kinase erbB-4. (182 aa)
	I79_007629	Lipin-1. (895 aa)
	I79_009371	Calcium-binding protein p22. (182 aa)
	I79_009991	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (152 aa)
	I79_010135	ADP-ribosylation factor 1. (72 aa)
	Chrm5	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
	Mtmr4	Myotubularin-related protein 4. (1200 aa)
	Stoml2	Stomatin-like protein 2. (353 aa)
	Mfsd2a	Major facilitator superfamily domain-containing protein 2. (527 aa)
	Mtmr3	Myotubularin-related protein 3. (1205 aa)
	Apoc2	Apolipoprotein C-II. (100 aa)
	Enpp7	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7. (809 aa)
	I79_014212	Putative G-protein coupled receptor 116; Belongs to the G-protein coupled receptor 2 family. (1938 aa)
	Dnajc19	Mitochondrial import inner membrane translocase subunit TIM14. (59 aa)
	Idh1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	I79_014552	Isocitrate dehydrogenase [NADP] cytoplasmic. (112 aa)
	I79_015046	Low-density lipoprotein receptor. (160 aa)
	Scarb1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	Htr2c	5-hydroxytryptamine receptor 2C. (317 aa)
	Pdgfb	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
	I79_024744	5-hydroxytryptamine receptor 2B. (407 aa)
	I79_018131	5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (237 aa)
	Htr2a	5-hydroxytryptamine receptor 2A. (264 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1178 aa)
	I79_018485	Isocitrate dehydrogenase [NADP] cytoplasmic. (235 aa)
	Rab38	Ras-related protein Rab-38-like protein. (211 aa)
	TAZ	Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (263 aa)
	I79_021929	Myotubularin-related protein 1. (376 aa)
	I79_022888	Calcium-binding protein p22. (54 aa)
	I79_023496	Seipin. (71 aa)
	I79_023498	Seipin. (163 aa)
	Acsl3	Long-chain-fatty-acid--CoA ligase 3. (709 aa)
	I79_024089	Lysophosphatidylcholine acyltransferase 1. (192 aa)
	Abca2	ATP-binding cassette sub-family A member 2. (457 aa)
	Bscl2	Leucine-rich repeat neuronal protein 4. (224 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abca2	Abca3	G3IJC3	G3I2S8	ATP-binding cassette sub-family A member 2.	ATP-binding cassette sub-family A member 3.	0.753
Abca2	Scarb1	G3IJC3	G3HX53	ATP-binding cassette sub-family A member 2.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.404
Abca3	Abca2	G3I2S8	G3IJC3	ATP-binding cassette sub-family A member 3.	ATP-binding cassette sub-family A member 2.	0.753
Acsl3	I79_023496	G3IK12	G3II35	Long-chain-fatty-acid--CoA ligase 3.	Seipin.	0.419
Acsl3	I79_023498	G3IK12	G3II37	Long-chain-fatty-acid--CoA ligase 3.	Seipin.	0.419
Acsl3	I79_024089	G3IK12	G3IJQ3	Long-chain-fatty-acid--CoA ligase 3.	Lysophosphatidylcholine acyltransferase 1.	0.426
Acsl3	Scp2	G3IK12	G3GW11	Long-chain-fatty-acid--CoA ligase 3.	Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.677
Apoc2	LDLR	G3HPD1	P35950	Apolipoprotein C-II.	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family.	0.635
Dnajc19	Phb2	G3HTK1	G3GUQ6	Mitochondrial import inner membrane translocase subunit TIM14.	Prohibitin-2.	0.875
Dnajc19	TAZ	G3HTK1	G3IBK7	Mitochondrial import inner membrane translocase subunit TIM14.	Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism.	0.563
Gnb3	Htr2c	G3GUP5	G3I0F8	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3.	5-hydroxytryptamine receptor 2C.	0.477
Gnb3	I79_024744	G3GUP5	G3ILH8	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3.	5-hydroxytryptamine receptor 2B.	0.477
Htr2a	Htr2c	G3I3W3	G3I0F8	5-hydroxytryptamine receptor 2A.	5-hydroxytryptamine receptor 2C.	0.964
Htr2a	I79_018131	G3I3W3	G3I3W2	5-hydroxytryptamine receptor 2A.	5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family.	0.852
Htr2a	I79_024744	G3I3W3	G3ILH8	5-hydroxytryptamine receptor 2A.	5-hydroxytryptamine receptor 2B.	0.568
Htr2c	Gnb3	G3I0F8	G3GUP5	5-hydroxytryptamine receptor 2C.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3.	0.477
Htr2c	Htr2a	G3I0F8	G3I3W3	5-hydroxytryptamine receptor 2C.	5-hydroxytryptamine receptor 2A.	0.964
Htr2c	I79_018131	G3I0F8	G3I3W2	5-hydroxytryptamine receptor 2C.	5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family.	0.649
Htr2c	I79_024744	G3I0F8	G3ILH8	5-hydroxytryptamine receptor 2C.	5-hydroxytryptamine receptor 2B.	0.621
I79_005331	I79_007089	G3H4W8	G3H9L3	Receptor tyrosine-protein kinase erbB-4.	Receptor tyrosine-protein kinase erbB-4.	0.899