STRINGSTRING
Tnf Tnf Htr1b Htr1b Gabbr1 Gabbr1 I79_015084 I79_015084 Gopc Gopc Htr6 Htr6 Slc43a1 Slc43a1 I79_011427 I79_011427 I79_011426 I79_011426 Hrh3 Hrh3 I79_006708 I79_006708 Rgs2 Rgs2 Adora1 Adora1 Hrh2 Hrh2 Grk6 Grk6 Lep Lep Abat Abat I79_019158 I79_019158 Npy5r Npy5r Htr1a Htr1a Agtr2 Agtr2 Prkg2 Prkg2 Slc43a2 Slc43a2 Sfrp4 Sfrp4 Arl6ip5 Arl6ip5 Mtor Mtor Trh Trh Sigirr Sigirr Il1rn Il1rn IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Htr1b5-hydroxytryptamine receptor 1B. (386 aa)
Gabbr1Gamma-aminobutyric acid type B receptor subunit 1. (401 aa)
I79_015084Gamma-aminobutyric acid type B receptor subunit 1. (281 aa)
GopcGolgi-associated PDZ and coiled-coil motif-containing protein. (424 aa)
Htr65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (406 aa)
Slc43a1Large neutral amino acids transporter small subunit 3. (607 aa)
I79_011427Protein FAM115C. (564 aa)
I79_011426Experimental autoimmune prostatitis antigen 2-like. (649 aa)
Hrh3Histamine H3 receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
I79_006708Secretory phospholipase A2 receptor. (593 aa)
Rgs2Regulator of G-protein signaling 2. (207 aa)
Adora1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
Hrh2Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. (358 aa)
Grk6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (551 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Abat4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa)
I79_019158Gamma-aminobutyric acid receptor subunit epsilon; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (360 aa)
Npy5rNeuropeptide Y receptor type 5-like protein. (466 aa)
Htr1a5-hydroxytryptamine receptor 1A. (422 aa)
Agtr2Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
Prkg2cGMP-dependent protein kinase 2. (546 aa)
Slc43a2Large neutral amino acids transporter small subunit 4. (217 aa)
Sfrp4Secreted frizzled-related protein 4. (348 aa)
Arl6ip5PRA1 family protein. (188 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
TrhPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (247 aa)
SigirrAnoctamin. (1092 aa)
Il1rnInterleukin-1. (157 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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