node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gabbr1 | I79_015084 | G3HVU3 | G3HVU2 | Gamma-aminobutyric acid type B receptor subunit 1. | Gamma-aminobutyric acid type B receptor subunit 1. | 0.918 |
Hrh2 | Hrh3 | G3H1A3 | G3HGW2 | Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. | Histamine H3 receptor; Belongs to the G-protein coupled receptor 1 family. | 0.922 |
Hrh3 | Hrh2 | G3HGW2 | G3H1A3 | Histamine H3 receptor; Belongs to the G-protein coupled receptor 1 family. | Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. | 0.922 |
Htr1a | Htr6 | G3I1B6 | G3HU32 | 5-hydroxytryptamine receptor 1A. | 5-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.463 |
Htr6 | Htr1a | G3HU32 | G3I1B6 | 5-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. | 5-hydroxytryptamine receptor 1A. | 0.463 |
I79_015084 | Gabbr1 | G3HVU2 | G3HVU3 | Gamma-aminobutyric acid type B receptor subunit 1. | Gamma-aminobutyric acid type B receptor subunit 1. | 0.918 |
IL1B | Il1rn | G3I1B0 | G3IHF8 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-1. | 0.663 |
IL1B | Lep | G3I1B0 | G3GZ86 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.620 |
IL1B | Tnf | G3I1B0 | G3HZG9 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.914 |
Il1rn | IL1B | G3IHF8 | G3I1B0 | Interleukin-1. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.663 |
Il1rn | Tnf | G3IHF8 | G3HZG9 | Interleukin-1. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.558 |
Lep | IL1B | G3GZ86 | G3I1B0 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.620 |
Lep | Tnf | G3GZ86 | G3HZG9 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.633 |
Lep | Trh | G3GZ86 | G3GS26 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. | 0.739 |
Prkg2 | Rgs2 | G3IIM1 | G3H4N6 | cGMP-dependent protein kinase 2. | Regulator of G-protein signaling 2. | 0.913 |
Rgs2 | Prkg2 | G3H4N6 | G3IIM1 | Regulator of G-protein signaling 2. | cGMP-dependent protein kinase 2. | 0.913 |
Tnf | IL1B | G3HZG9 | G3I1B0 | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.914 |
Tnf | Il1rn | G3HZG9 | G3IHF8 | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | Interleukin-1. | 0.558 |
Tnf | Lep | G3HZG9 | G3GZ86 | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.633 |
Trh | Lep | G3GS26 | G3GZ86 | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.739 |