STRINGSTRING
Mmp2 Mmp2 Edn1 Edn1 I79_003100 I79_003100 Src Src Agt Agt Gna12 Gna12 I79_001046 I79_001046 Ccdc142 Ccdc142 Pdcd4 Pdcd4 I79_018586 I79_018586 Foxj2 Foxj2 Adamts1 Adamts1 Nqo2 Nqo2 Jak2 Jak2 I79_022301 I79_022301 P2ry6 P2ry6 I79_022685 I79_022685 Mfn2 Mfn2 H671_1g2246 H671_1g2246 I79_024415 I79_024415 I79_024807 I79_024807 Pak1 Pak1 I79_025454 I79_025454 I79_025570 I79_025570 I79_025672 I79_025672 I79_025858 I79_025858 Dbh Dbh Tert Tert I79_026218 I79_026218 Drd4 Drd4 Pdgfb Pdgfb Efemp2 Efemp2 H671_1g1119 H671_1g1119 Ddx39b Ddx39b Tnf Tnf Frs2 Frs2 Adipoq Adipoq Ppargc1a Ppargc1a Sod2 Sod2 Htr1b Htr1b PPARG PPARG Gper1 Gper1 Ddr2 Ddr2 Rgs5 Rgs5 Cdkn1a Cdkn1a I79_009953 I79_009953 Mef2d Mef2d Tgfb3 Tgfb3 Cdkn1b Cdkn1b Il10 Il10 Mef2c Mef2c Cav1 Cav1 Mmp9 Mmp9 I79_006679 I79_006679 Gnai2 Gnai2 Gna13 Gna13 I79_006462 I79_006462 MED4 MED4 I79_005895 I79_005895 Dnmt1 Dnmt1 S1pr2 S1pr2 Cnn1 Cnn1 I79_005841 I79_005841 Igf1 Igf1 I79_005379 I79_005379 I79_013440 I79_013440 I79_013437 I79_013437 I79_026256 I79_026256 GNAI3 GNAI3 I79_021045 I79_021045 Hmox1 Hmox1 Igfbp5 Igfbp5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mmp272 kDa type IV collagenase. (662 aa)
Edn1Endothelin-1. (202 aa)
I79_003100Myocardin. (371 aa)
SrcTyrosine-protein kinase. (536 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
Gna12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
I79_001046Neurofibromin. (2164 aa)
Ccdc142Coiled-coil domain-containing protein 142. (723 aa)
Pdcd4Programmed cell death protein 4. (469 aa)
I79_018586Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
Foxj2Forkhead box protein J2. (573 aa)
Adamts1A disintegrin and metalloproteinase with thrombospondin motifs 1. (705 aa)
Nqo2Ribosyldihydronicotinamide dehydrogenase [quinone]. (231 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_022301Calcium/calmodulin-dependent protein kinase type II delta chain. (225 aa)
P2ry6p2Y purinoceptor 6. (328 aa)
I79_022685Dopamine beta-hydroxylase. (534 aa)
Mfn2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
H671_1g2246Protein NDRG2-like isoform 2. (328 aa)
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
I79_024807Protein FAM19A5. (87 aa)
Pak1Serine/threonine-protein kinase PAK 1. (325 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
I79_025570Spliceosome RNA helicase Bat1. (229 aa)
I79_025672Spliceosome RNA helicase BAT1. (155 aa)
I79_025858Spliceosome RNA helicase BAT1. (66 aa)
DbhDopamine beta-hydroxylase. (117 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
I79_026218Calcium/calmodulin-dependent protein kinase type II delta chain. (64 aa)
Drd4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
Efemp2EGF-containing fibulin-like extracellular matrix protein 2. (375 aa)
H671_1g111915-hydroxyprostaglandin dehydrogenase [NAD+]-like protein. (208 aa)
Ddx39bSpliceosome RNA helicase BAT1. (288 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Frs2Fibroblast growth factor receptor substrate 2. (509 aa)
AdipoqAdiponectin. (248 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Htr1b5-hydroxytryptamine receptor 1B. (386 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
Ddr2Discoidin domain-containing receptor 2. (854 aa)
Rgs5Regulator of G-protein signaling 5. (215 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
I79_009953Transcription factor AP-1. (72 aa)
Mef2dMyocyte-specific enhancer factor 2D. (505 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (198 aa)
Il10Interleukin-10. (178 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Gnai2Guanine nucleotide-binding protein G(I), alpha-2 subunit. (338 aa)
Gna13Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
I79_006462cGMP-dependent protein kinase 1, beta isozyme; Belongs to the protein kinase superfamily. (227 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (104 aa)
I79_005895DNA (Cytosine-5)-methyltransferase 1. (85 aa)
Dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1494 aa)
S1pr2Sphingosine 1-phosphate receptor 2. (352 aa)
Cnn1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
I79_005841Calponin-1. (79 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_005379Tropomyosin alpha-1 chain; Belongs to the tropomyosin family. (158 aa)
I79_013440Calcitonin gene-related peptide type 1 receptor. (426 aa)
I79_013437Nuclear receptor subfamily 4 group A member 3. (598 aa)
I79_026256Spliceosome RNA helicase Bat1. (103 aa)
GNAI3Guanine nucleotide binding protein alpha inhibiting 3. (354 aa)
I79_021045Heme oxygenase 1. (81 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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