STRINGSTRING
I79_021564 I79_021564 I79_021300 I79_021300 I79_020948 I79_020948 Inpp5f Inpp5f I79_011936 I79_011936 I79_011181 I79_011181 PRLR PRLR Ephb2 Ephb2 Akr1b1 Akr1b1 I79_009530 I79_009530 Dot1l Dot1l I79_008965 I79_008965 IL12B IL12B Neurod1 Neurod1 Cenpj Cenpj Ptprt Ptprt Cdk5 Cdk5 Il10 Il10 Pigu Pigu I79_007462 I79_007462 I79_007090 I79_007090 I79_007115 I79_007115 I79_007089 I79_007089 Cav1 Cav1 Ggnbp2 Ggnbp2 Mst1 Mst1 I79_006650 I79_006650 Tyk2 Tyk2 I79_005488 I79_005488 I79_005331 I79_005331 Adipor1 Adipor1 Socs3 Socs3 F2r F2r Sh2b3 Sh2b3 H671_5g13848 H671_5g13848 Mgat5 Mgat5 Lep Lep I79_002659 I79_002659 Hgs Hgs Socs1 Socs1 Rac1 Rac1 Crlf3 Crlf3 Nlk Nlk I79_000824 I79_000824 Parp14 Parp14 Tgfb1 Tgfb1 I79_018056 I79_018056 I79_018055 I79_018055 CgPICR_009833 CgPICR_009833 I79_018053 I79_018053 I79_018052 I79_018052 I79_018050 I79_018050 Clec12b Clec12b Hnf4a Hnf4a Tnf Tnf Leprot Leprot Jak1 Jak1 I79_015503 I79_015503 Agap2 Agap2 I79_015109 I79_015109 PPARG PPARG I79_013999 I79_013999 I79_013712 I79_013712 Il23a Il23a Nf2 Nf2 I79_012384 I79_012384 I79_012336 I79_012336 I79_025972 I79_025972 Il10ra Il10ra Kit Kit I79_024226 I79_024226 I79_011937 I79_011937 I79_024172 I79_024172 Sac3d1 Sac3d1 Cntf Cntf I79_022271 I79_022271 Jak2 Jak2 Ghr Ghr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_021564Pro-epidermal growth factor. (699 aa)
I79_021300Poly [ADP-ribose] polymerase. (324 aa)
I79_020948Interferon regulatory factor 1. (369 aa)
Inpp5fPhosphatidylinositide phosphatase SAC2. (842 aa)
I79_011936Prolactin-7A2. (148 aa)
I79_011181Interleukin-7 receptor subunit alpha. (257 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (605 aa)
Ephb2Ephrin type-B receptor 2. (1018 aa)
Akr1b1Aldose reductase. (316 aa)
I79_009530Receptor-type tyrosine-protein phosphatase delta. (1707 aa)
Dot1lHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1492 aa)
I79_008965Stimulated by retinoic acid gene 6 protein-like. (553 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
Neurod1Neurogenic differentiation factor. (355 aa)
CenpjCentromere protein J. (1341 aa)
PtprtReceptor-type tyrosine-protein phosphatase T. (320 aa)
Cdk5Cell division protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
Il10Interleukin-10. (178 aa)
PiguPhosphatidylinositol glycan anchor biosynthesis class U protein. (435 aa)
I79_007462Poly [ADP-ribose] polymerase 14. (125 aa)
I79_007090Receptor tyrosine-protein kinase erbB-4. (182 aa)
I79_007115Elongator complex protein 2. (859 aa)
I79_007089Receptor tyrosine-protein kinase erbB-4. (225 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Ggnbp2Gametogenetin-binding protein 2. (667 aa)
Mst1Hepatocyte growth factor-like protein. (88 aa)
I79_006650Hepatocyte growth factor-like protein. (93 aa)
Tyk2Tyrosine-protein kinase. (1182 aa)
I79_005488Progesterone-induced-blocking factor 1. (757 aa)
I79_005331Receptor tyrosine-protein kinase erbB-4. (480 aa)
Adipor1Adiponectin receptor protein 1. (375 aa)
Socs3Suppressor of cytokine signaling 3. (225 aa)
F2rProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (396 aa)
Sh2b3SH2B adapter protein 3. (364 aa)
H671_5g13848Interleukin-24-like protein. (160 aa)
Mgat5Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A. (740 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
I79_002659High mobility group protein HMGI-C. (103 aa)
HgsHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
Socs1Suppressor of cytokine signaling 1. (93 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (148 aa)
Crlf3Cytokine receptor-like factor 3. (76 aa)
NlkSerine/threonine protein kinase NLK. (410 aa)
I79_000824Interleukin-10 receptor beta chain. (349 aa)
Parp14Poly [ADP-ribose] polymerase. (1786 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
I79_018056Prolactin-3D4. (83 aa)
I79_018055Prolactin-6A1. (146 aa)
CgPICR_009833Prolactin-3B1. (216 aa)
I79_018053Prolactin-3B1. (114 aa)
I79_018052Prolactin-3D4. (185 aa)
I79_018050Prolactin-3D4. (172 aa)
Clec12bC-type lectin domain family 12 member B. (177 aa)
Hnf4aHepatocyte nuclear factor 4-alpha. (464 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
LeprotLeptin receptor gene-related protein. (131 aa)
Jak1Tyrosine-protein kinase. (1140 aa)
I79_015503Transcription factor HES-1. (92 aa)
Agap2Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (829 aa)
I79_015109Interleukin-6. (174 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
I79_013999Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (328 aa)
I79_013712Suppressor of cytokine signaling 2. (198 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
Nf2Merlin-like protein. (596 aa)
I79_012384Leukocyte common antigen. (962 aa)
I79_012336Protein tyrosine kinase 2 beta. (53 aa)
I79_025972Hepatocyte growth factor-regulated tyrosine kinase substrate. (147 aa)
Il10raInterleukin-10 receptor alpha chain. (353 aa)
KitMast/stem cell growth factor receptor. (452 aa)
I79_024226Interleukin-10 receptor alpha chain. (164 aa)
I79_011937Prolactin-5A1. (252 aa)
I79_024172Aldose reductase. (150 aa)
Sac3d1SAC3 domain-containing protein 1. (187 aa)
CntfCiliary neurotrophic factor. (59 aa)
I79_022271Ras-related C3 botulinum toxin substrate 2. (178 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
GhrGrowth hormone receptor. (345 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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