(42 nodes) Negative regulation of DNA biosynthetic process network (Cricetulus griseus)

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Your Input:
	I79_020554	Protection of telomeres protein 1. (490 aa)
	Chek1	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
	Men1	Menin. (610 aa)
	I79_016684	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa)
	Acd	Putative adrenocortical dysplasia protein like protein. (415 aa)
	Adipoq	Adiponectin. (248 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Dcp2	mRNA-decapping enzyme 2. (105 aa)
	Niban2	Niban-like protein 1. (368 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (637 aa)
	Ten1	Uncharacterized protein FLJ39785. (138 aa)
	Ahr	Aryl hydrocarbon receptor. (247 aa)
	H671_xg20125	Heterogeneous nuclear ribonucleoprotein A1-like protein 2. (151 aa)
	I79_011183	Dachshund-like 1. (326 aa)
	Cdkn1a	Cyclin-dependent kinase inhibitor 1. (163 aa)
	I79_010589	Heterogeneous nuclear ribonucleoprotein C-like 1. (70 aa)
	I79_008800	DnaJ-like subfamily C member 2. (467 aa)
	Pot1	Protection of telomeres protein 1. (375 aa)
	I79_008624	Protection of telomeres protein 1. (265 aa)
	Tinf2	TERF1-interacting nuclear factor 2. (413 aa)
	I79_007979	Heterogeneous nuclear ribonucleoproteins C1/C2. (228 aa)
	Dusp1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
	I79_006752	Heterogeneous nuclear ribonucleoprotein A1. (98 aa)
	Parp3	Poly [ADP-ribose] polymerase. (527 aa)
	Gnl3l	Guanine nucleotide-binding protein-like 3-like protein. (576 aa)
	Hnrnpu	Heterogeneous nuclear ribonucleoprotein U. (512 aa)
	I79_005612	PAP-associated domain-containing protein 5. (382 aa)
	Rgn	Regucalcin. (265 aa)
	Ankrd1	Ankyrin repeat domain-containing protein 1. (319 aa)
	I79_003672	Pin2-interacting protein X1. (329 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa)
	Hnrnpa1	Putative heterogeneous nuclear ribonucleoprotein A1-like protein 3. (340 aa)
	Bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	Ctc1	Uncharacterized protein C17orf68-like. (1215 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Kcnk2	Potassium channel subfamily K member 2. (215 aa)
	I79_022422	Heterogeneous nuclear ribonucleoprotein A1. (166 aa)
	Exosc10	Exosome component 10. (201 aa)
	Acvrl1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (776 aa)
	Gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	Nppc	C-type natriuretic peptide. (126 aa)
	Stn1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (378 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acd	Ctc1	G3HZM8	G3GY53	Putative adrenocortical dysplasia protein like protein.	Uncharacterized protein C17orf68-like.	0.737
Acd	I79_008624	G3HZM8	G3HDN8	Putative adrenocortical dysplasia protein like protein.	Protection of telomeres protein 1.	0.917
Acd	I79_016684	G3HZM8	G3I013	Putative adrenocortical dysplasia protein like protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.973
Acd	I79_020554	G3HZM8	G3IAD4	Putative adrenocortical dysplasia protein like protein.	Protection of telomeres protein 1.	0.917
Acd	Pot1	G3HZM8	G3HDN9	Putative adrenocortical dysplasia protein like protein.	Protection of telomeres protein 1.	0.917
Acd	Stn1	G3HZM8	G3IKU4	Putative adrenocortical dysplasia protein like protein.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.827
Acd	Ten1	G3HZM8	G3HTW3	Putative adrenocortical dysplasia protein like protein.	Uncharacterized protein FLJ39785.	0.685
Acd	Tinf2	G3HZM8	G3HDD2	Putative adrenocortical dysplasia protein like protein.	TERF1-interacting nuclear factor 2.	0.992
Acvrl1	Bmpr2	G3IC00	G3GYU9	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.974
Adipoq	PPARG	G3HYG0	G3HVG0	Adiponectin.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.885
Bmpr2	Acvrl1	G3GYU9	G3IC00	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.974
Chek1	PIF1	G3I7I8	G3HUZ6	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.555
Chek1	Parp3	G3I7I8	G3H896	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily.	Poly [ADP-ribose] polymerase.	0.516
Chek1	Stn1	G3I7I8	G3IKU4	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.606
Ctc1	Acd	G3GY53	G3HZM8	Uncharacterized protein C17orf68-like.	Putative adrenocortical dysplasia protein like protein.	0.737
Ctc1	I79_008624	G3GY53	G3HDN8	Uncharacterized protein C17orf68-like.	Protection of telomeres protein 1.	0.645
Ctc1	I79_016684	G3GY53	G3I013	Uncharacterized protein C17orf68-like.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.548
Ctc1	I79_020554	G3GY53	G3IAD4	Uncharacterized protein C17orf68-like.	Protection of telomeres protein 1.	0.646
Ctc1	Pot1	G3GY53	G3HDN9	Uncharacterized protein C17orf68-like.	Protection of telomeres protein 1.	0.645
Ctc1	Stn1	G3GY53	G3IKU4	Uncharacterized protein C17orf68-like.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.991