(104 nodes) Positive regulation of DNA biosynthetic process network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	I79_000010	Protein kinase C. (566 aa)
	Gins2	DNA replication complex GINS protein PSF2. (97 aa)
	I79_000259	DNA replication complex GINS protein PSF2. (61 aa)
	I79_000761	Non-specific serine/threonine protein kinase; Belongs to the PI3/PI4-kinase family. (1026 aa)
	I79_000778	T-complex protein 1 subunit theta; Belongs to the TCP-1 chaperonin family. (205 aa)
	Cct8	T-complex protein 1 subunit theta. (230 aa)
	I79_000806	Heat shock cognate protein HSP 90-beta. (102 aa)
	I79_001208	Replication factor C subunit 5. (407 aa)
	I79_002163	Poly(A)-specific ribonuclease PARN. (367 aa)
	I79_002328	T-complex protein 1 subunit gamma. (110 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Wrap53	Telomerase Cajal body protein 1; Belongs to the ephrin family. (619 aa)
	I79_002785	Beta-arrestin-2. (65 aa)
	I79_003659	Homeobox-containing protein 1. (219 aa)
	I79_003906	Fibroblast growth factor receptor 4. (1040 aa)
	CgPICR_012250	Disintegrin and metalloproteinase domain-containing protein 1. (706 aa)
	Mapkapk5	MAP kinase-activated protein kinase 5. (141 aa)
	Hsp90aa1	Heat shock protein HSP 90-alpha. (332 aa)
	Xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	Pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Tnks	Poly [ADP-ribose] polymerase. (897 aa)
	Gins1	DNA replication complex GINS protein PSF1. (161 aa)
	Cct5	T-complex protein 1 subunit epsilon. (541 aa)
	I79_006752	Heterogeneous nuclear ribonucleoprotein A1. (98 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Gsk3b	Glycogen synthase kinase-3 beta. (328 aa)
	I79_007634	Heat shock protein HSP 90-beta. (176 aa)
	Chtf18	Chromosome transmission fidelity protein 18-like. (968 aa)
	I79_008088	Heat shock protein HSP 90-beta. (412 aa)
	Polg2	DNA polymerase subunit gamma-2, mitochondrial. (51 aa)
	I79_008624	Protection of telomeres protein 1. (265 aa)
	Pot1	Protection of telomeres protein 1. (375 aa)
	I79_008649	T-complex protein 1 subunit delta. (397 aa)
	I79_009416	Serine-protein kinase ATM. (1640 aa)
	I79_009500	Mitogen-activated protein kinase 1. (68 aa)
	Cct3	T-complex protein 1 subunit gamma. (545 aa)
	Tcp1	T-complex protein 1 subunit alpha. (556 aa)
	I79_009795	Mitogen-activated protein kinase kinase kinase 4. (1824 aa)
	Rgcc	Response gene to complement 32 protein. (153 aa)
	Fbxo4	F-box only protein 4. (248 aa)
	Gins4	DNA replication complex GINS protein SLD5. (375 aa)
	Crhr2	Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (396 aa)
	Smoc2	SPARC-related modular calcium-binding protein 2. (457 aa)
	Pkib	cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (78 aa)
	Chtf8	Chromosome transmission fidelity protein 8-like. (121 aa)
	I79_011377	Grainyhead-like protein 2-like. (522 aa)
	I79_011633	Replication factor C subunit 2. (293 aa)
	I79_011769	Serine/threonine-protein kinase Nek7; Belongs to the protein kinase superfamily. (302 aa)
	I79_012336	Protein tyrosine kinase 2 beta. (53 aa)
	H671_xg20125	Heterogeneous nuclear ribonucleoprotein A1-like protein 2. (151 aa)
	Hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
	Ptges3	Prostaglandin E synthase 3. (214 aa)
	Map2k7	Dual specificity mitogen-activated protein kinase kinase 7. (391 aa)
	I79_013640	Heat shock protein HSP 90-alpha. (249 aa)
	I79_013660	Beta-type platelet-derived growth factor receptor. (454 aa)
	Pdgfrb	Beta-type platelet-derived growth factor receptor. (528 aa)
	I79_013999	Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (328 aa)
	Dkc1	H/ACA ribonucleoprotein complex subunit 4. (513 aa)
	I79_015386	Mitogen-activated protein kinase 15. (635 aa)
	Cct7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (499 aa)
	Rfc4	Replication factor C subunit 4. (362 aa)
	I79_016292	Heat shock protein HSP 90-alpha. (205 aa)
	I79_016293	Heat shock protein HSP 90-alpha 1. (135 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Ddx39b	Spliceosome RNA helicase BAT1. (288 aa)
	Pak3	Non-specific serine/threonine protein kinase. (544 aa)
	Acd	Putative adrenocortical dysplasia protein like protein. (415 aa)
	I79_016810	Serine-protein kinase ATM. (473 aa)
	Nvl	Nuclear valosin-containing protein-like; Belongs to the AAA ATPase family. (311 aa)
	Pdgfb	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
	Cct6a	T-complex protein 1 subunit zeta. (531 aa)
	Gins3	DNA replication complex GINS protein PSF3. (216 aa)
	I79_018104	DNA replication complex GINS protein PSF2. (188 aa)
	Mapk3	Mitogen-activated protein kinase. (408 aa)
	C3ar1	C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	I79_018653	Heat shock protein HSP 90-beta. (131 aa)
	Nek2	Serine/threonine-protein kinase Nek2. (400 aa)
	I79_018849	Serine/threonine-protein kinase D2. (513 aa)
	Pnkp	Bifunctional polynucleotide phosphatase/kinase. (522 aa)
	H671_2g6758	T-complex protein 1 subunit zeta; Belongs to the TCP-1 chaperonin family. (75 aa)
	Nox4	NADPH oxidase 4. (130 aa)
	Rfc3	Replication factor C subunit 3. (356 aa)
	Klf4	Krueppel-like factor 4. (474 aa)
	I79_021138	Heat shock protein HSP 90-beta. (90 aa)
	I79_021139	Heat shock protein HSP 90-beta. (113 aa)
	I79_021564	Pro-epidermal growth factor. (699 aa)
	I79_021590	Heat shock protein HSP 90-beta. (121 aa)
	Grem1	Gremlin-1. (117 aa)
	Parm1	Protein PARM-1. (251 aa)
	I79_022207	T-complex protein 1 subunit gamma. (55 aa)
	CgPICR_021058	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (338 aa)
	I79_022301	Calcium/calmodulin-dependent protein kinase type II delta chain. (225 aa)
	I79_022422	Heterogeneous nuclear ribonucleoprotein A1. (166 aa)
	Hnrnpa1	Putative heterogeneous nuclear ribonucleoprotein A1-like protein 3. (340 aa)
	I79_024082	Heat shock protein HSP 90-beta. (166 aa)
	I79_025570	Spliceosome RNA helicase Bat1. (229 aa)
	I79_025628	H/ACA ribonucleoprotein complex subunit 4. (91 aa)
	I79_025649	Sister chromatid cohesion protein DCC1. (155 aa)
	I79_025672	Spliceosome RNA helicase BAT1. (155 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	I79_025858	Spliceosome RNA helicase BAT1. (66 aa)
	I79_026208	Sister chromatid cohesion protein DCC1. (77 aa)
	I79_026218	Calcium/calmodulin-dependent protein kinase type II delta chain. (64 aa)
	I79_026256	Spliceosome RNA helicase Bat1. (103 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acd	Dkc1	G3HZM8	G3HV92	Putative adrenocortical dysplasia protein like protein.	H/ACA ribonucleoprotein complex subunit 4.	0.645
Acd	I79_008624	G3HZM8	G3HDN8	Putative adrenocortical dysplasia protein like protein.	Protection of telomeres protein 1.	0.917
Acd	I79_025628	G3HZM8	G3INT9	Putative adrenocortical dysplasia protein like protein.	H/ACA ribonucleoprotein complex subunit 4.	0.468
Acd	Pot1	G3HZM8	G3HDN9	Putative adrenocortical dysplasia protein like protein.	Protection of telomeres protein 1.	0.917
Acd	Wrap53	G3HZM8	G3GY67	Putative adrenocortical dysplasia protein like protein.	Telomerase Cajal body protein 1; Belongs to the ephrin family.	0.511
Cct3	Cct5	G3HG83	G3H7K5	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit epsilon.	0.989
Cct3	Cct6a	G3HG83	G3I2M1	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit zeta.	0.910
Cct3	Cct7	G3HG83	G3HYB7	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.929
Cct3	Cct8	G3HG83	G3GT06	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit theta.	0.913
Cct3	CgPICR_021058	G3HG83	G3IES9	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.933
Cct3	H671_2g6758	G3HG83	G3I735	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit zeta; Belongs to the TCP-1 chaperonin family.	0.861
Cct3	Hsp90aa1	G3HG83	G3H354	T-complex protein 1 subunit gamma.	Heat shock protein HSP 90-alpha.	0.401
Cct3	I79_000778	G3HG83	G3GT05	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit theta; Belongs to the TCP-1 chaperonin family.	0.860
Cct3	I79_000806	G3HG83	G3GT32	T-complex protein 1 subunit gamma.	Heat shock cognate protein HSP 90-beta.	0.401
Cct3	I79_007634	G3HG83	G3HB20	T-complex protein 1 subunit gamma.	Heat shock protein HSP 90-beta.	0.401
Cct3	I79_008088	G3HG83	G3HC84	T-complex protein 1 subunit gamma.	Heat shock protein HSP 90-beta.	0.401
Cct3	I79_008649	G3HG83	G3HDR3	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit delta.	0.977
Cct3	I79_013640	G3HG83	G3HS15	T-complex protein 1 subunit gamma.	Heat shock protein HSP 90-alpha.	0.401
Cct3	I79_016292	G3HG83	G3HYZ7	T-complex protein 1 subunit gamma.	Heat shock protein HSP 90-alpha.	0.401
Cct3	I79_016293	G3HG83	G3HYZ8	T-complex protein 1 subunit gamma.	Heat shock protein HSP 90-alpha 1.	0.401