(69 nodes) Caveola network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Grk2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
	Mapk3	Mitogen-activated protein kinase. (408 aa)
	Kif18a	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (877 aa)
	Flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	Cavin2	Serum deprivation-response protein. (415 aa)
	Akap6	A-kinase anchor protein 6. (1368 aa)
	I79_025828	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (184 aa)
	I79_025502	Adenylate cyclase type 8. (333 aa)
	I79_025355	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (325 aa)
	I79_024406	A-kinase anchor protein 6. (211 aa)
	Ptch1	Protein patched-like 1. (1114 aa)
	Cln3	Battenin. (400 aa)
	I79_023342	Solute carrier family 22 member 6. (513 aa)
	I79_022091	Protein kinase C delta-binding protein. (268 aa)
	I79_021837	Leucine-rich repeat serine/threonine-protein kinase 2. (441 aa)
	I79_021836	Leucine-rich repeat serine/threonine-protein kinase 2. (1184 aa)
	I79_021835	Leucine-rich repeat serine/threonine-protein kinase 2. (354 aa)
	Irs1	Insulin receptor substrate 1. (1233 aa)
	Trpc4	Short transient receptor potential channel 4-like protein; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
	Kcnd3	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (369 aa)
	I79_021045	Heme oxygenase 1. (81 aa)
	I79_021007	Potassium voltage-gated channel subfamily D member 3. (254 aa)
	Hmox1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
	Cdh15	Cadherin-15; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
	Cdh13	Cadherin-13. (377 aa)
	Atp1b3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (282 aa)
	I79_001015	Low-density lipoprotein receptor-related protein 8. (764 aa)
	Kcnma1	Uncharacterized protein. (462 aa)
	I79_002195	Calcium-activated potassium channel subunit alpha-1. (326 aa)
	Smpd2	Sphingomyelin phosphodiesterase 2. (313 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	I79_002707	Ran guanine nucleotide release factor. (163 aa)
	Bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	Dlc1	Rho GTPase-activating protein 7. (1082 aa)
	I79_003644	Rho GTPase-activating protein 7. (409 aa)
	Cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	Plvap	Plasmalemma vesicle-associated protein. (409 aa)
	I79_005331	Receptor tyrosine-protein kinase erbB-4. (480 aa)
	Hk1	Hexokinase-1. (917 aa)
	Tgfbr1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
	Atp1a2	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1194 aa)
	Atp1a1	Sodium/potassium-transporting ATPase subunit alpha. (773 aa)
	Myof	Myoferlin. (1449 aa)
	Cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	I79_007089	Receptor tyrosine-protein kinase erbB-4. (225 aa)
	I79_007090	Receptor tyrosine-protein kinase erbB-4. (182 aa)
	I79_007484	Kinesin-like protein KIF18A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (133 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Cacna1h	Voltage-dependent T-type calcium channel subunit alpha-1H. (2745 aa)
	Hck	Tyrosine-protein kinase. (503 aa)
	Ptgis	Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (501 aa)
	Plpp2	Lipid phosphate phosphohydrolase 2. (276 aa)
	I79_009500	Mitogen-activated protein kinase 1. (68 aa)
	P2ry12	p2Y purinoceptor 12. (345 aa)
	Coro1c	Coronin; Belongs to the WD repeat coronin family. (474 aa)
	I79_010863	Pituitary adenylate cyclase-activating polypeptide type I receptor; Belongs to the G-protein coupled receptor 2 family. (533 aa)
	Aqp1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	Igf1r	Insulin-like growth factor 1 receptor. (191 aa)
	Cdh1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
	Cavin1	Polymerase I and transcript release factor. (391 aa)
	Flot1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (418 aa)
	Ctnnd1	Catenin delta-1. (932 aa)
	Adtrp	Uncharacterized protein C6orf105-like. (148 aa)
	I79_015220	Neutral ceramidase. (474 aa)
	Insr	Insulin receptor. (114 aa)
	Scarb1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	I79_015895	Sorbin and SH3 domain-containing protein 1. (852 aa)
	CgPICR_015426	Ran guanine nucleotide release factor. (154 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akap6	Bmpr2	G3IAI2	G3GYU9	A-kinase anchor protein 6.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.576
Akap6	I79_024406	G3IAI2	G3IKK3	A-kinase anchor protein 6.	A-kinase anchor protein 6.	0.921
Aqp1	I79_010863	G3HJL7	G3HJL5	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Pituitary adenylate cyclase-activating polypeptide type I receptor; Belongs to the G-protein coupled receptor 2 family.	0.568
Atp1a1	Atp1a2	G3H8Z9	G3H7Y5	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.916
Atp1a1	Atp1b3	G3H8Z9	G3GSY1	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.984
Atp1a1	Mapk3	G3H8Z9	G3I4H1	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.911
Atp1a2	Atp1a1	G3H7Y5	G3H8Z9	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit alpha.	0.916
Atp1a2	Atp1b3	G3H7Y5	G3GSY1	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.972
Atp1a2	Mapk3	G3H7Y5	G3I4H1	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Mitogen-activated protein kinase.	0.911
Atp1b3	Atp1a1	G3GSY1	G3H8Z9	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit alpha.	0.984
Atp1b3	Atp1a2	G3GSY1	G3H7Y5	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.972
Atp1b3	Mapk3	G3GSY1	G3I4H1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Mitogen-activated protein kinase.	0.900
Bmpr2	Akap6	G3GYU9	G3IAI2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	A-kinase anchor protein 6.	0.576
Bmpr2	Tgfbr1	G3GYU9	G3H7H0	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.645
Bmpr2	Trpc4	G3GYU9	G3ID96	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Short transient receptor potential channel 4-like protein; Belongs to the transient receptor (TC 1.A.4) family.	0.912
Cacna1h	Cav3	G3HBW3	G3H113	Voltage-dependent T-type calcium channel subunit alpha-1H.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.653
Cacna1h	Kcnd3	G3HBW3	G3ID07	Voltage-dependent T-type calcium channel subunit alpha-1H.	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	0.461
Cacna1h	Trpc4	G3HBW3	G3ID96	Voltage-dependent T-type calcium channel subunit alpha-1H.	Short transient receptor potential channel 4-like protein; Belongs to the transient receptor (TC 1.A.4) family.	0.905
Cav1	Cav2	G3H9I8	G3H9I7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.998
Cav1	Cav3	G3H9I8	G3H113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.938