STRINGSTRING
I79_023244 I79_023244 I79_024415 I79_024415 Eif3e Eif3e I79_025454 I79_025454 Rpa1 Rpa1 Tert Tert Dapk3 Dapk3 I79_026101 I79_026101 Rb1 Rb1 Topors Topors I79_013082 I79_013082 I79_012926 I79_012926 I79_012607 I79_012607 Sqstm1 Sqstm1 Magt1 Magt1 Shkbp1 Shkbp1 Mlip Mlip Tp53inp1 Tp53inp1 I79_010245 I79_010245 Smc6 Smc6 Kat6a Kat6a Hipk2 Hipk2 I79_009832 I79_009832 I79_009767 I79_009767 Pml Pml I79_008145 I79_008145 Chek2 Chek2 Nr2c1 Nr2c1 Ikbke Ikbke I79_007550 I79_007550 Tp53inp2 Tp53inp2 Sirt1 Sirt1 Zmym2 Zmym2 I79_004964 I79_004964 Rpa2 Rpa2 H671_3g8832 H671_3g8832 I79_003898 I79_003898 Hoga1 Hoga1 Topbp1 Topbp1 Hipk3 Hipk3 I79_003024 I79_003024 Rpain Rpain Tp53 Tp53 Chd3 Chd3 I79_002131 I79_002131 Rnf6 Rnf6 Cdk9 Cdk9 I79_001964 I79_001964 Trim16 Trim16 I79_001756 I79_001756 I79_001733 I79_001733 Top3a Top3a I79_000761 I79_000761 Casp8ap2 Casp8ap2 Rnf111 Rnf111 I79_015356 I79_015356 Ppargc1a Ppargc1a N4bp1 N4bp1 Rnf4 Rnf4 Zbtb16 Zbtb16 I79_017450 I79_017450 I79_018592 I79_018592 CgPICR_012539 CgPICR_012539 Wdfy3 Wdfy3 Lrch4 Lrch4 I79_018974 I79_018974 Daxx Daxx Trim8 Trim8 I79_021076 I79_021076 Isg20 Isg20 Blm Blm I79_022868 I79_022868
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_023244Bloom syndrome protein-like. (721 aa)
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
Eif3eEukaryotic translation initiation factor 3 subunit E. (84 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
Rpa1Replication protein A 70 kDa DNA-binding subunit. (209 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
Dapk3Death-associated protein kinase 3. (530 aa)
I79_026101E3 SUMO-protein ligase NSE2. (68 aa)
Rb1Retinoblastoma-associated protein. (302 aa)
ToporsE3 ubiquitin-protein ligase Topors. (964 aa)
I79_013082Homeodomain-interacting protein kinase 1. (1249 aa)
I79_012926Death domain-associated protein 6. (393 aa)
I79_012607Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (568 aa)
Sqstm1Sequestosome-1. (358 aa)
Magt1Transcriptional regulator ATRX. (2344 aa)
Shkbp1SH3KBP1-binding protein 1. (1696 aa)
MlipUncharacterized protein C6orf142. (202 aa)
Tp53inp1Tumor protein p53-inducible nuclear protein 1. (239 aa)
I79_010245Structural maintenance of chromosomes protein 6. (141 aa)
Smc6Structural maintenance of chromosomes protein 6. (54 aa)
Kat6aHistone acetyltransferase MYST3. (200 aa)
Hipk2Homeodomain-interacting protein kinase 2. (1189 aa)
I79_009832G/T mismatch-specific thymine DNA glycosylase. (327 aa)
I79_009767Structural maintenance of chromosomes protein 6. (818 aa)
PmlPutative transcription factor PML. (540 aa)
I79_008145Zinc finger protein 605. (769 aa)
Chek2Serine/threonine-protein kinase Chk2. (539 aa)
Nr2c1Nuclear receptor subfamily 2 group C member 1. (590 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon. (640 aa)
I79_007550Eukaryotic translation initiation factor 3 subunit E; Belongs to the eIF-3 subunit E family. (263 aa)
Tp53inp2Tumor protein p53-inducible nuclear protein 2. (222 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Zmym2Zinc finger MYM-type protein 2. (1352 aa)
I79_004964ETS-related transcription factor Elf-4. (716 aa)
Rpa2Replication protein A 32 kDa subunit. (248 aa)
H671_3g8832E3 ubiquitin-protein ligase. (169 aa)
I79_003898RING finger protein 6. (477 aa)
Hoga1Dihydrodipicolinate synthase-like, mitochondrial. (804 aa)
Topbp1DNA topoisomerase II-binding protein 1. (1517 aa)
Hipk3Homeodomain-interacting protein kinase 3. (513 aa)
I79_003024Homeodomain-interacting protein kinase 3; Belongs to the protein kinase superfamily. (366 aa)
RpainRPA-interacting protein. (187 aa)
Tp53Cellular tumor antigen p53. (148 aa)
Chd3Chromodomain-helicase-DNA-binding protein 3. (126 aa)
I79_002131MHC class II transactivator. (1168 aa)
Rnf6E3 ubiquitin-protein ligase. (666 aa)
Cdk9Cell division protein kinase 9; Belongs to the protein kinase superfamily. (372 aa)
I79_001964Teneurin-2. (107 aa)
Trim16Tripartite motif-containing protein 16. (274 aa)
I79_001756Tripartite motif-containing protein 16. (197 aa)
I79_001733Mitogen-activated protein kinase. (1186 aa)
Top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1004 aa)
I79_000761Non-specific serine/threonine protein kinase; Belongs to the PI3/PI4-kinase family. (1026 aa)
Casp8ap2CASP8-associated protein 2. (1413 aa)
Rnf111E3 ubiquitin-protein ligase Arkadia. (990 aa)
I79_015356Heat shock factor protein 1. (524 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
N4bp1NEDD4-binding protein 1. (811 aa)
Rnf4RING finger protein 4. (128 aa)
Zbtb16Zinc finger and BTB domain-containing protein 16. (423 aa)
I79_017450Zinc finger and BTB domain-containing protein 16. (236 aa)
I79_018592Calcium-binding and coiled-coil domain-containing protein 2. (151 aa)
CgPICR_012539Small ubiquitin-related modifier. (112 aa)
Wdfy3WD repeat and FYVE domain-containing protein 3. (1924 aa)
Lrch4Leucine-rich repeat and calponin-likey domain-containing protein 4. (423 aa)
I79_018974Leucine-rich repeat and calponin-likey domain-containing protein 4. (253 aa)
DaxxDeath domain-associated protein 6. (708 aa)
Trim8Tripartite motif-containing protein 8. (551 aa)
I79_021076Calcium-binding and coiled-coil domain-containing protein 2. (104 aa)
Isg20Interferon-stimulated gene 20 kDa protein. (174 aa)
BlmATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (464 aa)
I79_022868G/T mismatch-specific thymine DNA glycosylase. (212 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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