(78 nodes) Growth factor receptor cysteine-rich domain superfamily network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_009586	Tyrosine-protein kinase receptor. (1183 aa)
	Ephb2	Ephrin type-B receptor 2. (1018 aa)
	Ccn6	WNT1-inducible-signaling pathway protein 3. (149 aa)
	I79_011419	Ephrin type-A receptor 1. (887 aa)
	Igfbp1	Insulin-like growth factor-binding protein 1. (272 aa)
	I79_021564	Pro-epidermal growth factor. (699 aa)
	Dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (578 aa)
	Creld2	Cysteine-rich with EGF-like domain protein 2. (308 aa)
	Esm1	Endothelial cell-specific molecule 1. (167 aa)
	Ccn2	Connective tissue growth factor-like protein. (348 aa)
	I79_020269	EGF-containing fibulin-like extracellular matrix protein 1. (438 aa)
	I79_020073	Latent-transforming growth factor beta-binding protein 2. (286 aa)
	Epha2	Ephrin type-A receptor 2. (942 aa)
	Gas6	Growth arrest-specific protein 6. (684 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2527 aa)
	Igfbp4	Insulin-like growth factor-binding protein 4. (254 aa)
	I79_018746	UPF0577 protein KIAA1324-like-like. (709 aa)
	I79_018113	Nidogen-1. (278 aa)
	I79_023125	Proprotein convertase subtilisin/kexin type 5. (661 aa)
	I79_024611	Signal peptide, CUB and EGF-like domain-containing protein 2. (583 aa)
	I79_024748	UPF0577 protein KIAA1324. (550 aa)
	Umod	Uromodulin. (618 aa)
	Rspo3	R-spondin-3. (81 aa)
	LDLR	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
	fur	Furin endoprotease; Belongs to the peptidase S8 family. (794 aa)
	Lrp1	Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
	I79_015544	Meckelin. (749 aa)
	I79_023010	Latent-transforming growth factor beta-binding protein 3. (624 aa)
	I79_023002	Receptor protein-tyrosine kinase. (650 aa)
	I79_022873	Extracellular matrix protein FRAS1. (1083 aa)
	I79_015127	EGF-like domain-containing protein C3orf50-like. (339 aa)
	I79_014532	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1. (2987 aa)
	I79_013621	Signal peptide, CUB and EGF-like domain-containing protein 3. (855 aa)
	I79_013556	Fibrillin-1. (2698 aa)
	I79_013535	Fibrillin-3. (1889 aa)
	Ikzf4	Receptor protein-tyrosine kinase. (1902 aa)
	Notch2	Neurogenic locus notch-like protein 2. (1521 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Shkbp1	SH3KBP1-binding protein 1. (1696 aa)
	Zfyve1	Zinc finger FYVE domain-containing protein 1. (513 aa)
	Nrxn1	Neurexin-1-alpha. (849 aa)
	I79_011804	Neurogenic locus notch-like protein 3. (2181 aa)
	Matn4	Matrilin-4. (597 aa)
	I79_011565	Crumbs-like 2. (1065 aa)
	I79_022667	Fibulin-1. (628 aa)
	Wrap73	Multiple epidermal growth factor-like domains 6. (1488 aa)
	Ccn1	Protein CYR61. (491 aa)
	Cd93	Complement component C1q receptor. (811 aa)
	I79_017864	Fibrillin-2. (2601 aa)
	Fat4	Protocadherin Fat 4. (5152 aa)
	Efemp2	EGF-containing fibulin-like extracellular matrix protein 2. (375 aa)
	Gpsm3	Neurogenic locus notch-like protein 4. (1797 aa)
	I79_015855	Signal peptide, CUB and EGF-like domain-containing protein 1. (773 aa)
	I79_015624	Thrombospondin-4. (960 aa)
	Fat1	Protocadherin Fat 1. (4589 aa)
	I79_000317	Fibulin-2. (1193 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	I79_000654	Mucin-13. (196 aa)
	I79_000700	Receptor protein-tyrosine kinase. (871 aa)
	I79_001015	Low-density lipoprotein receptor-related protein 8. (764 aa)
	I79_001239	Low-density lipoprotein receptor-related protein 2. (4664 aa)
	I79_001957	Slit-like 3 protein. (751 aa)
	Brinp3	Protein FAM5C. (690 aa)
	I79_002246	Hemicentin-1. (1801 aa)
	Creld1	Cysteine-rich with EGF-like domain protein 1. (420 aa)
	I79_003394	Metalloendopeptidase. (995 aa)
	I79_003408	Slit-like 1 protein. (1482 aa)
	I79_004721	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1234 aa)
	Igfbp5	Insulin-like growth factor-binding protein 5. (271 aa)
	Erbb2	Receptor protein-tyrosine kinase. (1256 aa)
	I79_007089	Receptor tyrosine-protein kinase erbB-4. (225 aa)
	I79_007339	Protein NOV-like. (256 aa)
	I79_008232	EGF-like module-containing mucin-like hormone receptor-like 1; Belongs to the G-protein coupled receptor 2 family. (944 aa)
	Pkn1	Serine/threonine-protein kinase N1; Belongs to the G-protein coupled receptor 2 family. (1696 aa)
	Rspo1	R-spondin-1. (262 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	I79_009063	Scavenger receptor class F member 2. (731 aa)
	I79_009100	Latent-transforming growth factor beta-binding protein 1. (1194 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccn2	I79_009100	G3IAP3	G3HEV3	Connective tissue growth factor-like protein.	Latent-transforming growth factor beta-binding protein 1.	0.520
Ccn2	I79_013556	G3IAP3	G3HRT4	Connective tissue growth factor-like protein.	Fibrillin-1.	0.449
Ccn2	I79_017864	G3IAP3	G3I363	Connective tissue growth factor-like protein.	Fibrillin-2.	0.413
Ccn2	I79_021564	G3IAP3	G3ID03	Connective tissue growth factor-like protein.	Pro-epidermal growth factor.	0.460
Dll1	Dll4	G3HNT7	G3ICK3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll1	Esm1	G3HNT7	G3IAX2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Endothelial cell-specific molecule 1.	0.420
Dll1	Gpsm3	G3HNT7	G3HZC0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 4.	0.767
Dll1	I79_011804	G3HNT7	G3HM56	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 3.	0.888
Dll1	Jag1	G3HNT7	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
Dll1	NOTCH1	G3HNT7	G3I6Z6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.995
Dll1	Notch2	G3HNT7	G3HP78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.978
Dll4	Dll1	G3ICK3	G3HNT7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll4	Esm1	G3ICK3	G3IAX2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Endothelial cell-specific molecule 1.	0.489
Dll4	Gpsm3	G3ICK3	G3HZC0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 4.	0.803
Dll4	I79_004721	G3ICK3	G3H3A6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.552
Dll4	I79_011804	G3ICK3	G3HM56	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 3.	0.888
Dll4	I79_023002	G3ICK3	G3IGS6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Receptor protein-tyrosine kinase.	0.449
Dll4	Jag1	G3ICK3	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.503
Dll4	NOTCH1	G3ICK3	G3I6Z6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.998
Dll4	Notch2	G3ICK3	G3HP78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.975