STRINGSTRING
I79_002596 I79_002596 Il21 Il21 IL2 IL2 I79_015109 I79_015109 I79_016108 I79_016108 Flt3lg Flt3lg I79_016858 I79_016858 I79_016859 I79_016859 CgPICR_010784 CgPICR_010784 I79_016862 I79_016862 I79_016863 I79_016863 I79_016864 I79_016864 CgPICR_010786 CgPICR_010786 I79_016866 I79_016866 I79_016867 I79_016867 I79_016868 I79_016868 Ifng Ifng I79_002597 I79_002597 Il23a Il23a I79_002595 I79_002595 I79_002594 I79_002594 Ifnb1 Ifnb1 I79_016869 I79_016869 I79_016870 I79_016870 Ifne Ifne Lif Lif Osm Osm I79_018050 I79_018050 I79_018051 I79_018051 I79_018052 I79_018052 I79_018053 I79_018053 CgPICR_009833 CgPICR_009833 I79_018055 I79_018055 I79_018056 I79_018056 Clcf1 Clcf1 Epo Epo I79_020343 I79_020343 I79_020344 I79_020344 Csf1 Csf1 Cntf Cntf I79_024209 I79_024209 Csf3 Csf3 Lep Lep H671_5g13848 H671_5g13848 I79_003375 I79_003375 Il19 Il19 I79_004319 I79_004319 Csf2 Csf2 Il10 Il10 Gh1 Gh1 Kitlg Kitlg Ifnk Ifnk Il15 Il15 I79_011936 I79_011936 I79_011937 I79_011937 IL12A IL12A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_002596Interferon alpha-9. (212 aa)
Il21Interleukin-21. (67 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
I79_015109Interleukin-6. (174 aa)
I79_016108Protein FAM71E2. (197 aa)
Flt3lgSL cytokine. (230 aa)
I79_016858Interferon alpha-9. (183 aa)
I79_016859Interferon alpha-12. (183 aa)
CgPICR_010784Interferon alpha-9. (195 aa)
I79_016862Interferon alpha-12. (190 aa)
I79_016863Interferon alpha-12. (190 aa)
I79_016864Interferon alpha-2. (164 aa)
CgPICR_010786Interferon alpha-12. (189 aa)
I79_016866Interferon alpha-12. (190 aa)
I79_016867Interferon alpha-6. (193 aa)
I79_016868Interferon alpha-12. (180 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
I79_002597Interferon alpha-12. (186 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
I79_002595Interferon alpha-12. (190 aa)
I79_002594Interferon alpha-12. (186 aa)
Ifnb1Interferon beta. (182 aa)
I79_016869Interferon alpha-12. (190 aa)
I79_016870Interferon alpha-12. (190 aa)
IfneInterferon epsilon. (192 aa)
LifLeukemia inhibitory factor-like protein. (158 aa)
OsmOncostatin-M. (222 aa)
I79_018050Prolactin-3D4. (172 aa)
I79_018051Prolactin. (225 aa)
I79_018052Prolactin-3D4. (185 aa)
I79_018053Prolactin-3B1. (114 aa)
CgPICR_009833Prolactin-3B1. (216 aa)
I79_018055Prolactin-6A1. (146 aa)
I79_018056Prolactin-3D4. (83 aa)
Clcf1Cardiotrophin-like cytokine factor 1. (225 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
I79_020343Cardiotrophin-2. (229 aa)
I79_020344Cardiotrophin-1. (203 aa)
Csf1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
CntfCiliary neurotrophic factor. (59 aa)
I79_024209Interleukin-27 subunit alpha. (240 aa)
Csf3Granulocyte colony-stimulating factor. (208 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
H671_5g13848Interleukin-24-like protein. (160 aa)
I79_003375Interleukin-20. (147 aa)
Il19Interleukin-19. (177 aa)
I79_004319DNA repair protein RAD50. (680 aa)
Csf2Granulocyte-macrophage colony-stimulating factor. (95 aa)
Il10Interleukin-10. (178 aa)
Gh1Somatotropin. (212 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
IfnkInterferon kappa. (244 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
I79_011936Prolactin-7A2. (148 aa)
I79_011937Prolactin-5A1. (252 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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