(50 nodes) Nuclear hormone receptor-like domain superfamily network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rora	Nuclear receptor ROR-alpha. (959 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (393 aa)
	I79_022390	Peroxisome proliferator-activated receptor alpha. (110 aa)
	Rorb	Nuclear receptor ROR-beta. (440 aa)
	Vdr	Vitamin D3 receptor. (372 aa)
	Rxra	Retinoic acid receptor RXR-alpha. (439 aa)
	I79_021840	Nuclear receptor ROR-gamma. (341 aa)
	Nr5a2	Nuclear receptor subfamily 5 group A member 2. (301 aa)
	Nr2f1	COUP transcription factor 1-like protein. (263 aa)
	Nr6a1	Nuclear receptor subfamily 6 group A member 1. (376 aa)
	Nr5a1	Steroidogenic factor 1. (462 aa)
	Esrra	Steroid hormone receptor ERR1. (548 aa)
	Nr1h2	Oxysterols receptor LXR-beta. (445 aa)
	I79_019286	Androgen receptor. (295 aa)
	I79_018785	Retinoic acid receptor alpha. (484 aa)
	Nr1d1	Nuclear receptor subfamily 1 group D member 1. (508 aa)
	Thra	Thyroid hormone receptor alpha. (493 aa)
	Hnf4a	Hepatocyte nuclear factor 4-alpha. (464 aa)
	Nr0b2	Nuclear receptor subfamily 0 group B member 2. (260 aa)
	Nr0b1	Nuclear receptor subfamily 0 group B member 1. (470 aa)
	I79_014995	Bile acid receptor. (747 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Esrrg	Estrogen-related receptor gamma. (435 aa)
	Nr2c2	Nuclear receptor subfamily 2 group C member 2. (596 aa)
	Nr2f2	COUP transcription factor 2. (261 aa)
	Esr1	Estrogen receptor. (200 aa)
	I79_001487	Progesterone receptor. (741 aa)
	I79_002496	Nuclear receptor subfamily 2 group E member 1. (323 aa)
	Nr1h3	Oxysterols receptor LXR-alpha. (402 aa)
	I79_003385	Hepatocyte nuclear factor 4-gamma. (288 aa)
	Thrb	Thyroid hormone receptor beta. (377 aa)
	Nr2e3	Photoreceptor-specific nuclear receptor. (395 aa)
	Nr2f6	Nuclear receptor subfamily 2 group F member 6. (91 aa)
	Rarb	Retinoic acid receptor beta. (284 aa)
	Rarg	Retinoic acid receptor gamma. (458 aa)
	Nr1i3	Nuclear receptor subfamily 1 group I member 3-like isoform 1. (279 aa)
	Nr4a2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	Ppard	Peroxisome proliferator-activated receptor delta. (440 aa)
	I79_013437	Nuclear receptor subfamily 4 group A member 3. (598 aa)
	Rxrb	Retinoic acid receptor RXR-beta. (101 aa)
	I79_012760	Retinoic acid receptor RXR-gamma. (414 aa)
	I79_010801	Bile acid receptor. (352 aa)
	I79_009443	Steroid hormone receptor ERR2. (475 aa)
	Nr3c1	Glucocorticoid receptor. (748 aa)
	Nr2c1	Nuclear receptor subfamily 2 group C member 1. (590 aa)
	Nr1i2	Nuclear receptor subfamily 1 group I member 2. (432 aa)
	I79_006966	Mineralocorticoid receptor. (301 aa)
	I79_005358	Estrogen receptor beta. (58 aa)
	I79_025880	Thyroid hormone receptor alpha. (77 aa)
	I79_023773	Nuclear receptor subfamily 4 group A member 1. (924 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Esr1	Esrra	G3GU19	G3I885	Estrogen receptor.	Steroid hormone receptor ERR1.	0.411
Esr1	Hnf4a	G3GU19	G3I0S8	Estrogen receptor.	Hepatocyte nuclear factor 4-alpha.	0.426
Esr1	I79_001487	G3GU19	G3GUW3	Estrogen receptor.	Progesterone receptor.	0.990
Esr1	I79_005358	G3GU19	G3H4Z4	Estrogen receptor.	Estrogen receptor beta.	0.963
Esr1	I79_019286	G3GU19	G3I705	Estrogen receptor.	Androgen receptor.	0.833
Esr1	Nr0b2	G3GU19	G3HYP7	Estrogen receptor.	Nuclear receptor subfamily 0 group B member 2.	0.454
Esr1	Nr1i2	G3GU19	G3HAH7	Estrogen receptor.	Nuclear receptor subfamily 1 group I member 2.	0.410
Esr1	Nr3c1	G3GU19	G3HEK6	Estrogen receptor.	Glucocorticoid receptor.	0.619
Esr1	Nr5a1	G3GU19	G3I9D5	Estrogen receptor.	Steroidogenic factor 1.	0.571
Esr1	Nr5a2	G3GU19	G3IDG7	Estrogen receptor.	Nuclear receptor subfamily 5 group A member 2.	0.465
Esr1	PPARG	G3GU19	G3HVG0	Estrogen receptor.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.638
Esrra	Esr1	G3I885	G3GU19	Steroid hormone receptor ERR1.	Estrogen receptor.	0.411
Esrra	Esrrg	G3I885	G3GRF2	Steroid hormone receptor ERR1.	Estrogen-related receptor gamma.	0.671
Esrra	I79_009443	G3I885	G3HFS8	Steroid hormone receptor ERR1.	Steroid hormone receptor ERR2.	0.570
Esrra	I79_022390	G3I885	G3IF74	Steroid hormone receptor ERR1.	Peroxisome proliferator-activated receptor alpha.	0.448
Esrra	Nr0b1	G3I885	G3HXG4	Steroid hormone receptor ERR1.	Nuclear receptor subfamily 0 group B member 1.	0.422
Esrra	PPARG	G3I885	G3HVG0	Steroid hormone receptor ERR1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.599
Esrrg	Esrra	G3GRF2	G3I885	Estrogen-related receptor gamma.	Steroid hormone receptor ERR1.	0.671
Esrrg	Nr0b1	G3GRF2	G3HXG4	Estrogen-related receptor gamma.	Nuclear receptor subfamily 0 group B member 1.	0.567
Esrrg	Nr0b2	G3GRF2	G3HYP7	Estrogen-related receptor gamma.	Nuclear receptor subfamily 0 group B member 2.	0.509