(47 nodes) Signalling to ERKs network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Frs2	Fibroblast growth factor receptor substrate 2. (509 aa)
	Mapk14	Mitogen-activated protein kinase. (349 aa)
	I79_016797	Dual specificity mitogen-activated protein kinase kinase 1. (129 aa)
	I79_017306	GTPase ERas. (167 aa)
	I79_017749	Mitogen-activated protein kinase 11. (413 aa)
	Hras	GTPase HRas-like protein. (189 aa)
	Mapk3	Mitogen-activated protein kinase. (408 aa)
	I79_020221	GTPase ERas. (151 aa)
	Rap1a	Ras-related protein Rap-1A. (184 aa)
	I79_022484	Rap guanine nucleotide exchange factor 1. (934 aa)
	I79_023702	Ral guanine nucleotide dissociation stimulator. (754 aa)
	CgPICR_020372	GTPase ERas. (182 aa)
	I79_025218	GTPase ERas. (178 aa)
	I79_025453	GTPase ERas. (177 aa)
	I79_025505	GTPase ERas. (96 aa)
	Map2k1	Dual specificity mitogen-activated protein kinase kinase 1. (101 aa)
	I79_025571	GTPase ERas. (155 aa)
	I79_025579	GTPase ERas. (260 aa)
	CgPICR_023615	GTPase ERas. (137 aa)
	Shc2	SHC-transforming protein 2. (570 aa)
	I79_009500	Mitogen-activated protein kinase 1. (68 aa)
	Crkl	Crk-like protein. (303 aa)
	I79_009585	Tyrosine-protein kinase receptor. (727 aa)
	Rit1	GTP-binding protein Rit1. (219 aa)
	I79_009740	B-Raf proto-oncogene serine/threonine-protein kinase. (229 aa)
	Shc3	SHC-transforming protein 3. (486 aa)
	Ngf	Beta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
	I79_005532	Ras-related protein Ral-B. (227 aa)
	Kras	GTPase KRas. (155 aa)
	I79_003162	GTPase ERas. (106 aa)
	H671_4g12632	GTPase ERas-like protein. (144 aa)
	Shc1	SHC-transforming protein 1. (579 aa)
	Rala	Ras-related protein Ral-A. (206 aa)
	CgPICR_012052	Growth factor receptor-bound protein 2. (217 aa)
	Mapkapk2	MAPKAPK2. (307 aa)
	I79_006611	MAP kinase-activated protein kinase 3. (283 aa)
	Mapkapk3	MAP kinase-activated protein kinase 3. (244 aa)
	I79_010806	Cold shock domain-containing protein E1. (255 aa)
	Csde1	Cold shock domain-containing protein E1. (95 aa)
	Ywhab	14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
	Kidins220	Kinase D-interacting substrate of 220 kDa. (1747 aa)
	Eras	GTPase ERas. (228 aa)
	Nras	Cold shock domain-containing protein E1. (451 aa)
	Shc4	SHC-transforming protein 4. (228 aa)
	Map2k2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (380 aa)
	Crk	Proto-oncogene C-crk. (327 aa)
	I79_014706	GTPase ERas. (126 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CgPICR_012052	CgPICR_020372	G3GTE4	G3IL61	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	CgPICR_023615	G3GTE4	G3IP24	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	Crk	G3GTE4	G3HTF8	Growth factor receptor-bound protein 2.	Proto-oncogene C-crk.	0.892
CgPICR_012052	Crkl	G3GTE4	G3HFZ9	Growth factor receptor-bound protein 2.	Crk-like protein.	0.867
CgPICR_012052	Csde1	G3GTE4	G3HKJ4	Growth factor receptor-bound protein 2.	Cold shock domain-containing protein E1.	0.508
CgPICR_012052	Eras	G3GTE4	G3HND1	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	Frs2	G3GTE4	G3HZ39	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor substrate 2.	0.986
CgPICR_012052	H671_4g12632	G3GTE4	G3GYG7	Growth factor receptor-bound protein 2.	GTPase ERas-like protein.	0.508
CgPICR_012052	Hras	G3GTE4	G3I3F4	Growth factor receptor-bound protein 2.	GTPase HRas-like protein.	0.838
CgPICR_012052	I79_003162	G3GTE4	G3GZA2	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	I79_005532	G3GTE4	G3H5E5	Growth factor receptor-bound protein 2.	Ras-related protein Ral-B.	0.604
CgPICR_012052	I79_009500	G3GTE4	G3HFY3	Growth factor receptor-bound protein 2.	Mitogen-activated protein kinase 1.	0.461
CgPICR_012052	I79_009585	G3GTE4	G3HG66	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.719
CgPICR_012052	I79_009740	G3GTE4	G3HGK2	Growth factor receptor-bound protein 2.	B-Raf proto-oncogene serine/threonine-protein kinase.	0.485
CgPICR_012052	I79_010806	G3GTE4	G3HJG1	Growth factor receptor-bound protein 2.	Cold shock domain-containing protein E1.	0.508
CgPICR_012052	I79_014706	G3GTE4	G3HUU0	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	I79_017306	G3GTE4	G3I1P3	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	I79_020221	G3GTE4	G3I9H4	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	I79_022484	G3GTE4	G3IFG2	Growth factor receptor-bound protein 2.	Rap guanine nucleotide exchange factor 1.	0.906
CgPICR_012052	I79_025218	G3GTE4	G3IMS3	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508