STRINGSTRING
H671_3g8910 H671_3g8910 Fgf1 Fgf1 Fgf22 Fgf22 Fgf3 Fgf3 Fgf7 Fgf7 Fgfr2 Fgfr2 Fgfbp1 Fgfbp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H671_3g8910Fibroblast growth factor-binding protein 3. (71 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Fgf22Fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (70 aa)
Fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
Fgfbp1Fibroblast growth factor-binding protein 1. (248 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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