(19 nodes) Pre-NOTCH Expression and Processing network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	I79_015223	Neurogenic locus notch-like protein 2. (248 aa)
	Lfng	Beta-1,3-N-acetylglucosaminyltransferase. (378 aa)
	Rfng	Beta-1,3-N-acetylglucosaminyltransferase radical fringe. (229 aa)
	I79_003037	ETS-related transcription factor Elf-5. (232 aa)
	Ehf	ETS-likeous factor. (282 aa)
	Maml2	Mastermind-like protein 2. (914 aa)
	I79_011762	Crumbs-like 1. (107 aa)
	I79_011804	Neurogenic locus notch-like protein 3. (2181 aa)
	Notch2	Neurogenic locus notch-like protein 2. (1521 aa)
	Tnrc6b	Trinucleotide repeat-containing gene 6B protein. (1810 aa)
	Tmed2	Transmembrane emp24 domain-containing protein 2. (116 aa)
	POFUT1	GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] (392 aa)
	Gpsm3	Neurogenic locus notch-like protein 4. (1797 aa)
	I79_017261	KTEL motif-containing protein 1. (333 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2527 aa)
	Mov10	Putative helicase MOV-10. (948 aa)
	Mfng	Beta-1,3-N-acetylglucosaminyltransferase manic fringe. (324 aa)
	Prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (560 aa)
	Crb1	Crumbs-like 1. (989 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Crb1	NOTCH1	G3HM16	G3I6Z6	Crumbs-like 1.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.429
Gpsm3	I79_011804	G3HZC0	G3HM56	Neurogenic locus notch-like protein 4.	Neurogenic locus notch-like protein 3.	0.642
Gpsm3	I79_015223	G3HZC0	G3HW73	Neurogenic locus notch-like protein 4.	Neurogenic locus notch-like protein 2.	0.438
Gpsm3	Maml2	G3HZC0	G3H7E1	Neurogenic locus notch-like protein 4.	Mastermind-like protein 2.	0.736
Gpsm3	NOTCH1	G3HZC0	G3I6Z6	Neurogenic locus notch-like protein 4.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.450
Gpsm3	Notch2	G3HZC0	G3HP78	Neurogenic locus notch-like protein 4.	Neurogenic locus notch-like protein 2.	0.465
Gpsm3	Tmed2	G3HZC0	G3HX40	Neurogenic locus notch-like protein 4.	Transmembrane emp24 domain-containing protein 2.	0.641
I79_011804	Gpsm3	G3HM56	G3HZC0	Neurogenic locus notch-like protein 3.	Neurogenic locus notch-like protein 4.	0.642
I79_011804	Lfng	G3HM56	G3GVF0	Neurogenic locus notch-like protein 3.	Beta-1,3-N-acetylglucosaminyltransferase.	0.433
I79_011804	Maml2	G3HM56	G3H7E1	Neurogenic locus notch-like protein 3.	Mastermind-like protein 2.	0.565
I79_011804	NOTCH1	G3HM56	G3I6Z6	Neurogenic locus notch-like protein 3.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.484
I79_011804	Tmed2	G3HM56	G3HX40	Neurogenic locus notch-like protein 3.	Transmembrane emp24 domain-containing protein 2.	0.453
I79_015223	Gpsm3	G3HW73	G3HZC0	Neurogenic locus notch-like protein 2.	Neurogenic locus notch-like protein 4.	0.438
I79_015223	Tmed2	G3HW73	G3HX40	Neurogenic locus notch-like protein 2.	Transmembrane emp24 domain-containing protein 2.	0.452
I79_017261	POFUT1	G3I1J9	P83337	KTEL motif-containing protein 1.	GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...]	0.701
Lfng	I79_011804	G3GVF0	G3HM56	Beta-1,3-N-acetylglucosaminyltransferase.	Neurogenic locus notch-like protein 3.	0.433
Lfng	Mfng	G3GVF0	G3IJX8	Beta-1,3-N-acetylglucosaminyltransferase.	Beta-1,3-N-acetylglucosaminyltransferase manic fringe.	0.906
Lfng	NOTCH1	G3GVF0	G3I6Z6	Beta-1,3-N-acetylglucosaminyltransferase.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.954
Lfng	Notch2	G3GVF0	G3HP78	Beta-1,3-N-acetylglucosaminyltransferase.	Neurogenic locus notch-like protein 2.	0.959
Lfng	POFUT1	G3GVF0	P83337	Beta-1,3-N-acetylglucosaminyltransferase.	GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...]	0.692