(10 nodes) Regulated proteolysis of p75NTR network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_005386	Gamma-secretase subunit APH-1B. (196 aa)
	I79_005385	Gamma-secretase subunit APH-1B. (219 aa)
	Aph1a	Gamma-secretase subunit APH-1A. (247 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Ngfr	Tumor necrosis factor receptor superfamily member 16. (429 aa)
	Ncstn	Nicastrin. (615 aa)
	Nfkb1	Nuclear factor NF-kappa-B p105 subunit. (509 aa)
	I79_025482	Nuclear factor NF-kappa-B p105 subunit. (144 aa)
	I79_023268	Disintegrin and metalloproteinase domain-containing protein 17. (527 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aph1a	Ncstn	G3H2V5	G3H7X9	Gamma-secretase subunit APH-1A.	Nicastrin.	0.999
Aph1a	Psen1	G3H2V5	G3HNF2	Gamma-secretase subunit APH-1A.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
Aph1a	Psen2	G3H2V5	G3HV76	Gamma-secretase subunit APH-1A.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
I79_005385	Ncstn	G3H516	G3H7X9	Gamma-secretase subunit APH-1B.	Nicastrin.	0.961
I79_005385	Psen1	G3H516	G3HNF2	Gamma-secretase subunit APH-1B.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.951
I79_005385	Psen2	G3H516	G3HV76	Gamma-secretase subunit APH-1B.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.951
I79_005386	Ncstn	G3H517	G3H7X9	Gamma-secretase subunit APH-1B.	Nicastrin.	0.961
I79_005386	Psen1	G3H517	G3HNF2	Gamma-secretase subunit APH-1B.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.951
I79_005386	Psen2	G3H517	G3HV76	Gamma-secretase subunit APH-1B.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.951
I79_023268	Ncstn	G3IHH8	G3H7X9	Disintegrin and metalloproteinase domain-containing protein 17.	Nicastrin.	0.594
I79_023268	Ngfr	G3IHH8	G3HJP7	Disintegrin and metalloproteinase domain-containing protein 17.	Tumor necrosis factor receptor superfamily member 16.	0.692
I79_023268	Psen1	G3IHH8	G3HNF2	Disintegrin and metalloproteinase domain-containing protein 17.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.407
I79_023268	Psen2	G3IHH8	G3HV76	Disintegrin and metalloproteinase domain-containing protein 17.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.506
I79_025482	Nfkb1	G3ING1	G3INJ4	Nuclear factor NF-kappa-B p105 subunit.	Nuclear factor NF-kappa-B p105 subunit.	0.899
Ncstn	Aph1a	G3H7X9	G3H2V5	Nicastrin.	Gamma-secretase subunit APH-1A.	0.999
Ncstn	I79_005385	G3H7X9	G3H516	Nicastrin.	Gamma-secretase subunit APH-1B.	0.961
Ncstn	I79_005386	G3H7X9	G3H517	Nicastrin.	Gamma-secretase subunit APH-1B.	0.961
Ncstn	I79_023268	G3H7X9	G3IHH8	Nicastrin.	Disintegrin and metalloproteinase domain-containing protein 17.	0.594
Ncstn	Psen1	G3H7X9	G3HNF2	Nicastrin.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
Ncstn	Psen2	G3H7X9	G3HV76	Nicastrin.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999