(24 nodes) Signaling by NOTCH1 network (Cricetulus griseus)

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second shell of interactors

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Predicted Interactions

gene neighborhood

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Your Input:
	I79_007126	E3 ubiquitin-protein ligase NEURL1B. (286 aa)
	Maml2	Mastermind-like protein 2. (914 aa)
	Kat2b	Histone acetyltransferase KAT2B. (191 aa)
	I79_007270	Protein deltex-2. (601 aa)
	Itch	E3 ubiquitin-protein ligase. (851 aa)
	Nbea	Neurobeachin. (503 aa)
	I79_009652	Neurobeachin. (785 aa)
	I79_009653	Neurobeachin. (417 aa)
	I79_009702	E3 ubiquitin-protein ligase MIB1. (739 aa)
	Lrba	Lipopolysaccharide-responsive and beige-like anchor protein. (138 aa)
	Heyl	Hairy/enhancer-of-split related with YRPW motif-like protein. (300 aa)
	I79_015033	Hairy/enhancer-of-split related with YRPW motif protein 1. (199 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Ubc	Ubiquitin. (430 aa)
	Dlk1	Protein delta-like 1. (361 aa)
	Ep300	Histone acetyltransferase p300. (2415 aa)
	H671_4g12762	Protein deltex-1-like protein. (466 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2527 aa)
	I79_019429	Contactin-1. (461 aa)
	Hey2	Hairy/enhancer-of-split related with YRPW motif protein 2. (276 aa)
	Dner	Delta and Notch-like epidermal growth factor-related receptor. (272 aa)
	I79_022671	Delta and Notch-like epidermal growth factor-related receptor. (176 aa)
	Dtx4	Protein deltex-4. (619 aa)
	I79_025262	Delta and Notch-like epidermal growth factor-related receptor. (111 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dlk1	NOTCH1	G3I3S2	G3I6Z6	Protein delta-like 1.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.622
Dner	I79_022671	G3IFZ3	G3IFZ5	Delta and Notch-like epidermal growth factor-related receptor.	Delta and Notch-like epidermal growth factor-related receptor.	0.927
Dner	I79_025262	G3IFZ3	G3IMV9	Delta and Notch-like epidermal growth factor-related receptor.	Delta and Notch-like epidermal growth factor-related receptor.	0.899
Dtx4	NOTCH1	G3IJM3	G3I6Z6	Protein deltex-4.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.919
Ep300	Kat2b	G3I534	G3H8L4	Histone acetyltransferase p300.	Histone acetyltransferase KAT2B.	0.996
Ep300	Maml2	G3I534	G3H7E1	Histone acetyltransferase p300.	Mastermind-like protein 2.	0.935
Ep300	NOTCH1	G3I534	G3I6Z6	Histone acetyltransferase p300.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.766
Ep300	Ubc	G3I534	G3I129	Histone acetyltransferase p300.	Ubiquitin.	0.627
H671_4g12762	Itch	G3I6U6	G3HAN9	Protein deltex-1-like protein.	E3 ubiquitin-protein ligase.	0.762
H671_4g12762	NOTCH1	G3I6U6	G3I6Z6	Protein deltex-1-like protein.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.766
H671_4g12762	Ubc	G3I6U6	G3I129	Protein deltex-1-like protein.	Ubiquitin.	0.637
Hey2	Heyl	G3IB43	G3HN78	Hairy/enhancer-of-split related with YRPW motif protein 2.	Hairy/enhancer-of-split related with YRPW motif-like protein.	0.935
Hey2	I79_015033	G3IB43	G3HVP3	Hairy/enhancer-of-split related with YRPW motif protein 2.	Hairy/enhancer-of-split related with YRPW motif protein 1.	0.668
Hey2	Maml2	G3IB43	G3H7E1	Hairy/enhancer-of-split related with YRPW motif protein 2.	Mastermind-like protein 2.	0.450
Hey2	NOTCH1	G3IB43	G3I6Z6	Hairy/enhancer-of-split related with YRPW motif protein 2.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.674
Heyl	Hey2	G3HN78	G3IB43	Hairy/enhancer-of-split related with YRPW motif-like protein.	Hairy/enhancer-of-split related with YRPW motif protein 2.	0.935
Heyl	Maml2	G3HN78	G3H7E1	Hairy/enhancer-of-split related with YRPW motif-like protein.	Mastermind-like protein 2.	0.548
Heyl	NOTCH1	G3HN78	G3I6Z6	Hairy/enhancer-of-split related with YRPW motif-like protein.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.534
I79_007126	I79_009702	G3H9P7	G3HGH5	E3 ubiquitin-protein ligase NEURL1B.	E3 ubiquitin-protein ligase MIB1.	0.621
I79_007126	Ubc	G3H9P7	G3I129	E3 ubiquitin-protein ligase NEURL1B.	Ubiquitin.	0.448