(82 nodes) Cell death signalling via NRAGE, NRIF and NADE network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ccdc28a	Epithelial cell transforming sequence 2 oncogene-like. (939 aa)
	Net1	Neuroepithelial cell-transforming gene 1 protein. (540 aa)
	I79_000658	Kalirin. (2681 aa)
	Tiam1	T-lymphoma invasion and metastasis-inducing protein 1. (1591 aa)
	Itsn1	Intersectin-1. (1213 aa)
	I79_001186	T-lymphoma invasion and metastasis-inducing protein 2. (714 aa)
	Tiam2	T-lymphoma invasion and metastasis-inducing protein 2. (722 aa)
	Arhgef3	Rho guanine nucleotide exchange factor 3. (524 aa)
	Rac1	Ras-related C3 botulinum toxin substrate 1. (148 aa)
	Arhgef15	Rho guanine nucleotide exchange factor 15. (110 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	I79_003316	Rho guanine nucleotide exchange factor 10. (1350 aa)
	I79_003468	Bcl-2-like protein 11. (141 aa)
	I79_004112	Rho guanine nucleotide exchange factor 4. (142 aa)
	Arhgef4	Rho guanine nucleotide exchange factor 4. (297 aa)
	Aph1a	Gamma-secretase subunit APH-1A. (247 aa)
	I79_005054	Protein-glutamine gamma-glutamyltransferase 6. (664 aa)
	Tgm3	Protein-glutamine gamma-glutamyltransferase E. (681 aa)
	I79_005385	Gamma-secretase subunit APH-1B. (219 aa)
	I79_005386	Gamma-secretase subunit APH-1B. (196 aa)
	Ect2	Protein ECT2. (881 aa)
	Arhgef6	Rho guanine nucleotide exchange factor 6. (765 aa)
	Fgd1	FYVE, RhoGEF and PH domain-containing protein 1. (131 aa)
	Ncstn	Nicastrin. (615 aa)
	Gna13	Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
	Sestd1	SEC14 domain and spectrin repeat-containing protein 1. (696 aa)
	I79_007470	Triple functional domain protein. (497 aa)
	I79_008231	Proto-oncogene vav. (879 aa)
	I79_009581	Rho guanine nucleotide exchange factor 11. (1472 aa)
	Arhgef2	Rho guanine nucleotide exchange factor 2. (1031 aa)
	I79_010128	Obscurin. (1605 aa)
	I79_010129	Obscurin. (6993 aa)
	I79_010779	Pleckstrin-likey domain-containing family G member 2. (520 aa)
	Plekhg2	Pleckstrin-likey domain-containing family G member 2. (736 aa)
	Ngf	Beta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
	Ngfr	Tumor necrosis factor receptor superfamily member 16. (429 aa)
	Mcf2l	Guanine nucleotide exchange factor DBS. (955 aa)
	I79_011154	FYVE, RhoGEF and PH domain-containing protein 2. (359 aa)
	Fgd2	FYVE, RhoGEF and PH domain-containing protein 2. (250 aa)
	Casp2	Caspase-2; Belongs to the peptidase C14A family. (421 aa)
	Arhgef5	Rho guanine nucleotide exchange factor 5. (1561 aa)
	Arhgef39	Vav-like protein C9orf100-like. (326 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Sqstm1	Sequestosome-1. (358 aa)
	I79_013352	Breakpoint cluster region protein. (379 aa)
	I79_013988	DH and coiled-coil domain-containing protein ENSP00000381780-like. (529 aa)
	Abr	Active breakpoint cluster region-related protein. (769 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	Arhgef40	Protein SOLO. (1323 aa)
	I79_015470	Uncharacterized protein. (394 aa)
	Arhgef18	Rho guanine nucleotide exchange factor 18. (898 aa)
	I79_015634	Ras-specific guanine nucleotide-releasing factor 2. (128 aa)
	Bex3	Protein BEX3-like protein. (114 aa)
	Arhgef26	SH3 domain-containing guanine exchange factor. (846 aa)
	I79_016524	Puratrophin-1. (619 aa)
	Arhgef37	Putative guanine nucleotide exchange factor FLJ41603-like. (625 aa)
	I79_016920	Rho guanine nucleotide exchange factor 1. (791 aa)
	Ubc	Ubiquitin. (430 aa)
	Arhgef7	Rho guanine nucleotide exchange factor 7. (646 aa)
	I79_017859	A-kinase anchor protein 13. (2703 aa)
	I79_019403	Ras-specific guanine nucleotide-releasing factor 2. (287 aa)
	I79_019725	Rho guanine nucleotide exchange factor 19. (584 aa)
	Sos2	Son of sevenless-like 2. (166 aa)
	I79_020262	Ephexin-1. (573 aa)
	Arhgef9	Rho guanine nucleotide exchange factor 9 isoform 1. (472 aa)
	I79_020316	Guanine nucleotide exchange factor VAV3. (604 aa)
	Fgd4	FYVE, RhoGEF and PH domain-containing protein 4. (665 aa)
	Arhgef12	Rho guanine nucleotide exchange factor 12. (371 aa)
	I79_021949	Caspase-3; Belongs to the peptidase C14A family. (195 aa)
	I79_022271	Ras-related C3 botulinum toxin substrate 2. (178 aa)
	Arhgef10l	Rho guanine nucleotide exchange factor 10-like protein. (1029 aa)
	Arhgef16	Rho guanine nucleotide exchange factor 16. (796 aa)
	Arhgef17	Rho guanine nucleotide exchange factor 17. (1723 aa)
	I79_023828	Ras-specific guanine nucleotide-releasing factor 2. (584 aa)
	I79_023894	Putative Rho guanine nucleotide exchange factor FLJ20184-like. (299 aa)
	I79_023998	Guanine nucleotide exchange factor VAV2. (93 aa)
	I79_024363	Pleckstrin-likey domain-containing family G member 5. (593 aa)
	Vav2	Guanine nucleotide exchange factor VAV2. (453 aa)
	I79_024372	Guanine nucleotide exchange factor VAV2. (233 aa)
	I79_024429	Putative guanine nucleotide exchange factor FLJ41603-like. (362 aa)
	I79_025660	Rho guanine nucleotide exchange factor 10-like protein. (264 aa)
	I79_026021	14-3-3 protein epsilon; Belongs to the 14-3-3 family. (70 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abr	Arhgef18	G3HTH3	G3HWV8	Active breakpoint cluster region-related protein.	Rho guanine nucleotide exchange factor 18.	0.484
Abr	I79_015470	G3HTH3	G3HWV7	Active breakpoint cluster region-related protein.	Uncharacterized protein.	0.403
Abr	I79_022271	G3HTH3	G3IEW6	Active breakpoint cluster region-related protein.	Ras-related C3 botulinum toxin substrate 2.	0.413
Abr	Rac1	G3HTH3	G3GVB5	Active breakpoint cluster region-related protein.	Ras-related C3 botulinum toxin substrate 1.	0.413
Aph1a	Ncstn	G3H2V5	G3H7X9	Gamma-secretase subunit APH-1A.	Nicastrin.	0.999
Aph1a	Psen1	G3H2V5	G3HNF2	Gamma-secretase subunit APH-1A.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
Aph1a	Psen2	G3H2V5	G3HV76	Gamma-secretase subunit APH-1A.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
Arhgef10l	I79_009581	G3IF57	G3HG62	Rho guanine nucleotide exchange factor 10-like protein.	Rho guanine nucleotide exchange factor 11.	0.419
Arhgef10l	I79_025660	G3IF57	G3INW5	Rho guanine nucleotide exchange factor 10-like protein.	Rho guanine nucleotide exchange factor 10-like protein.	0.927
Arhgef12	Arhgef17	G3IDN8	G3IFR8	Rho guanine nucleotide exchange factor 12.	Rho guanine nucleotide exchange factor 17.	0.437
Arhgef12	Arhgef6	G3IDN8	G3H6K2	Rho guanine nucleotide exchange factor 12.	Rho guanine nucleotide exchange factor 6.	0.939
Arhgef12	Arhgef7	G3IDN8	G3I1U6	Rho guanine nucleotide exchange factor 12.	Rho guanine nucleotide exchange factor 7.	0.945
Arhgef12	Ect2	G3IDN8	G3H6H0	Rho guanine nucleotide exchange factor 12.	Protein ECT2.	0.538
Arhgef12	Gna13	G3IDN8	G3H860	Rho guanine nucleotide exchange factor 12.	Guanine nucleotide-binding protein subunit alpha-13.	0.992
Arhgef12	I79_000658	G3IDN8	G3GSP1	Rho guanine nucleotide exchange factor 12.	Kalirin.	0.415
Arhgef12	I79_003316	G3IDN8	G3GZM6	Rho guanine nucleotide exchange factor 12.	Rho guanine nucleotide exchange factor 10.	0.485
Arhgef12	I79_007470	G3IDN8	G3HAL1	Rho guanine nucleotide exchange factor 12.	Triple functional domain protein.	0.415
Arhgef12	I79_009581	G3IDN8	G3HG62	Rho guanine nucleotide exchange factor 12.	Rho guanine nucleotide exchange factor 11.	0.460
Arhgef12	I79_013988	G3IDN8	G3HSY8	Rho guanine nucleotide exchange factor 12.	DH and coiled-coil domain-containing protein ENSP00000381780-like.	0.413
Arhgef12	I79_017859	G3IDN8	G3I358	Rho guanine nucleotide exchange factor 12.	A-kinase anchor protein 13.	0.437