(58 nodes) HSF1-dependent transactivation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_002177	Calcium/calmodulin-dependent protein kinase type II gamma chain. (507 aa)
	I79_026218	Calcium/calmodulin-dependent protein kinase type II delta chain. (64 aa)
	I79_024708	Heat shock cognate 71 kDa protein. (136 aa)
	I79_024259	Heat shock protein HSP 90-beta. (73 aa)
	I79_024082	Heat shock protein HSP 90-beta. (166 aa)
	I79_022977	Heat shock cognate 71 kDa protein. (79 aa)
	I79_022974	Heat shock cognate 71 kDa protein. (207 aa)
	I79_022973	Heat shock cognate 71 kDa protein. (70 aa)
	I79_022301	Calcium/calmodulin-dependent protein kinase type II delta chain. (225 aa)
	I79_022117	Uncharacterized protein. (151 aa)
	I79_022115	Uncharacterized protein. (170 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	I79_021801	Heat shock cognate 71 kDa protein. (406 aa)
	I79_021800	Heat shock cognate 71 kDa protein. (209 aa)
	Hspa8	Heat shock cognate 71 kDa protein. (237 aa)
	I79_021590	Heat shock protein HSP 90-beta. (121 aa)
	I79_021139	Heat shock protein HSP 90-beta. (113 aa)
	I79_021138	Heat shock protein HSP 90-beta. (90 aa)
	I79_020374	DnaJ-like subfamily B member 13. (316 aa)
	Hspb7	Heat shock protein beta-7; Belongs to the small heat shock protein (HSP20) family. (108 aa)
	Akt1s1	Proline-rich AKT1 substrate 1. (252 aa)
	I79_018653	Heat shock protein HSP 90-beta. (131 aa)
	Ep300	Histone acetyltransferase p300. (2415 aa)
	I79_016692	CREB-binding protein. (1054 aa)
	Nol3	Heat shock factor protein 4; Belongs to the HSF family. (915 aa)
	I79_016448	Heat shock 70 kDa protein 1L; Belongs to the heat shock protein 70 family. (641 aa)
	Hspa1a	Heat shock 70 kDa protein 1A/1B; Belongs to the heat shock protein 70 family. (641 aa)
	I79_016446	Heat shock 70 kDa protein 1A; Belongs to the heat shock protein 70 family. (641 aa)
	I79_016293	Heat shock protein HSP 90-alpha 1. (135 aa)
	I79_016292	Heat shock protein HSP 90-alpha. (205 aa)
	I79_015356	Heat shock factor protein 1. (524 aa)
	Hspb3	Heat shock protein beta-3; Belongs to the small heat shock protein (HSP20) family. (152 aa)
	I79_013707	CREB-binding protein. (202 aa)
	I79_013706	CREB-binding protein. (759 aa)
	I79_013640	Heat shock protein HSP 90-alpha. (249 aa)
	Ptges3	Prostaglandin E synthase 3. (214 aa)
	Dnajb5	DnaJ-like subfamily B member 5. (177 aa)
	I79_011859	Calcium/calmodulin-dependent protein kinase type II beta chain. (337 aa)
	Hspb9	Heat shock protein beta-9; Belongs to the small heat shock protein (HSP20) family. (162 aa)
	CgPICR_016026	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
	I79_011236	Heat shock factor protein 2. (398 aa)
	Dnajb1	DnaJ-like subfamily B member 1. (340 aa)
	I79_008088	Heat shock protein HSP 90-beta. (412 aa)
	Metrn	Meteorin. (383 aa)
	Mlst8	Target of rapamycin complex subunit LST8. (326 aa)
	I79_007634	Heat shock protein HSP 90-beta. (176 aa)
	I79_006342	Heat shock factor-binding protein 1. (90 aa)
	Hspa2	Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (634 aa)
	Hsp90aa1	Heat shock protein HSP 90-alpha. (332 aa)
	Hspb2	Heat shock protein beta-2; Belongs to the small heat shock protein (HSP20) family. (257 aa)
	Cryab	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	Rptor	Regulatory-associated protein of mTOR. (1331 aa)
	Txndc11	Thioredoxin domain-containing protein 11. (551 aa)
	Dnajb4	DnaJ-like subfamily B member 4. (398 aa)
	Fkbp4	Peptidylprolyl isomerase. (411 aa)
	Hspb8	Heat shock protein beta-8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
	I79_000806	Heat shock cognate protein HSP 90-beta. (102 aa)
	CgPICR_015914	Heat shock factor-binding protein 1. (128 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1s1	Mlst8	G3I716	G3HBR5	Proline-rich AKT1 substrate 1.	Target of rapamycin complex subunit LST8.	0.997
Akt1s1	Mtor	G3I716	G3IEE8	Proline-rich AKT1 substrate 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.999
Akt1s1	Rptor	G3I716	G3GX53	Proline-rich AKT1 substrate 1.	Regulatory-associated protein of mTOR.	0.999
CgPICR_015914	Cryab	G3GRY7	G3H2H2	Heat shock factor-binding protein 1.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.447
CgPICR_015914	Hspb8	G3GRY7	G3GU64	Heat shock factor-binding protein 1.	Heat shock protein beta-8; Belongs to the small heat shock protein (HSP20) family.	0.433
CgPICR_015914	I79_011236	G3GRY7	G3HKK7	Heat shock factor-binding protein 1.	Heat shock factor protein 2.	0.558
CgPICR_015914	I79_015356	G3GRY7	G3HWM4	Heat shock factor-binding protein 1.	Heat shock factor protein 1.	0.618
CgPICR_015914	I79_022115	G3GRY7	G3IEG8	Heat shock factor-binding protein 1.	Uncharacterized protein.	0.512
CgPICR_015914	I79_022117	G3GRY7	G3IEH0	Heat shock factor-binding protein 1.	Uncharacterized protein.	0.512
CgPICR_015914	Metrn	G3GRY7	G3HBU6	Heat shock factor-binding protein 1.	Meteorin.	0.512
CgPICR_015914	Nol3	G3GRY7	G3HZK7	Heat shock factor-binding protein 1.	Heat shock factor protein 4; Belongs to the HSF family.	0.570
CgPICR_016026	Cryab	G3HLE9	G3H2H2	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.873
CgPICR_016026	I79_011236	G3HLE9	G3HKK7	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock factor protein 2.	0.456
CgPICR_016026	I79_015356	G3HLE9	G3HWM4	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock factor protein 1.	0.456
CgPICR_016026	Nol3	G3HLE9	G3HZK7	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock factor protein 4; Belongs to the HSF family.	0.502
Cryab	CgPICR_015914	G3H2H2	G3GRY7	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock factor-binding protein 1.	0.447
Cryab	CgPICR_016026	G3H2H2	G3HLE9	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.873
Cryab	Dnajb1	G3H2H2	G3HD21	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	DnaJ-like subfamily B member 1.	0.635
Cryab	Dnajb4	G3H2H2	G3GVT1	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	DnaJ-like subfamily B member 4.	0.457
Cryab	Dnajb5	G3H2H2	G3HN15	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	DnaJ-like subfamily B member 5.	0.419