(67 nodes) Nuclear Receptor transcription pathway network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Esrrg	Estrogen-related receptor gamma. (435 aa)
	Nr2c2	Nuclear receptor subfamily 2 group C member 2. (596 aa)
	Nr2f2	COUP transcription factor 2. (261 aa)
	Esr1	Estrogen receptor. (200 aa)
	I79_001487	Progesterone receptor. (741 aa)
	Ncor1	Nuclear receptor corepressor 1. (1591 aa)
	I79_001744	Nuclear receptor corepressor 1. (680 aa)
	I79_002496	Nuclear receptor subfamily 2 group E member 1. (323 aa)
	Nrbp1	Nuclear receptor-binding protein. (535 aa)
	Nr1h3	Oxysterols receptor LXR-alpha. (402 aa)
	I79_003385	Hepatocyte nuclear factor 4-gamma. (288 aa)
	Nr1d2	Nuclear receptor subfamily 1 group D member 2. (265 aa)
	Thrb	Thyroid hormone receptor beta. (377 aa)
	Nr2e3	Photoreceptor-specific nuclear receptor. (395 aa)
	Nr2f6	Nuclear receptor subfamily 2 group F member 6. (91 aa)
	I79_005213	Nuclear receptor domain-containing protein. (162 aa)
	Rarb	Retinoic acid receptor beta. (284 aa)
	I79_005358	Estrogen receptor beta. (58 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	Nr3c2	Mineralocorticoid receptor. (586 aa)
	I79_006966	Mineralocorticoid receptor. (301 aa)
	I79_006980	Centrosomal protein of 55 kDa. (107 aa)
	Nrbf2	Nuclear receptor-binding factor 2. (243 aa)
	Nr1i2	Nuclear receptor subfamily 1 group I member 2. (432 aa)
	Nr2c1	Nuclear receptor subfamily 2 group C member 1. (590 aa)
	Nr3c1	Glucocorticoid receptor. (748 aa)
	I79_009443	Steroid hormone receptor ERR2. (475 aa)
	Map3k1	Mitogen-activated protein kinase kinase kinase 1. (1340 aa)
	I79_010801	Bile acid receptor. (352 aa)
	I79_012760	Retinoic acid receptor RXR-gamma. (414 aa)
	Rxrb	Retinoic acid receptor RXR-beta. (101 aa)
	I79_013437	Nuclear receptor subfamily 4 group A member 3. (598 aa)
	Ppard	Peroxisome proliferator-activated receptor delta. (440 aa)
	Nr4a2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	Nr1i3	Nuclear receptor subfamily 1 group I member 3-like isoform 1. (279 aa)
	Rarg	Retinoic acid receptor gamma. (458 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	I79_014995	Bile acid receptor. (747 aa)
	Ncor2	Nuclear receptor corepressor 2. (2530 aa)
	Nr0b1	Nuclear receptor subfamily 0 group B member 1. (470 aa)
	I79_016172	Nuclear receptor-binding factor 2. (195 aa)
	Nr0b2	Nuclear receptor subfamily 0 group B member 2. (260 aa)
	Hnf4a	Hepatocyte nuclear factor 4-alpha. (464 aa)
	Thra	Thyroid hormone receptor alpha. (493 aa)
	Nr1d1	Nuclear receptor subfamily 1 group D member 1. (508 aa)
	I79_018785	Retinoic acid receptor alpha. (484 aa)
	I79_019286	Androgen receptor. (295 aa)
	Nr1h2	Oxysterols receptor LXR-beta. (445 aa)
	Esrra	Steroid hormone receptor ERR1. (548 aa)
	I79_019916	Nuclear receptor-binding factor 2. (172 aa)
	Nr5a1	Steroidogenic factor 1. (462 aa)
	Nr6a1	Nuclear receptor subfamily 6 group A member 1. (376 aa)
	Nr2f1	COUP transcription factor 1-like protein. (263 aa)
	Nr5a2	Nuclear receptor subfamily 5 group A member 2. (301 aa)
	I79_021840	Nuclear receptor ROR-gamma. (341 aa)
	Rxra	Retinoic acid receptor RXR-alpha. (439 aa)
	Vdr	Vitamin D3 receptor. (372 aa)
	Rorb	Nuclear receptor ROR-beta. (440 aa)
	I79_022390	Peroxisome proliferator-activated receptor alpha. (110 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (393 aa)
	Rora	Nuclear receptor ROR-alpha. (959 aa)
	Ar	Androgen receptor. (517 aa)
	I79_023773	Nuclear receptor subfamily 4 group A member 1. (924 aa)
	I79_025745	Nuclear receptor subfamily 1 group D member 1. (226 aa)
	I79_025795	Vitamin D3 receptor. (86 aa)
	I79_025880	Thyroid hormone receptor alpha. (77 aa)
	Nr2c2ap	Nuclear receptor 2C2-associated protein. (140 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ar	Esr1	G3IGU9	G3GU19	Androgen receptor.	Estrogen receptor.	0.893
Ar	I79_001487	G3IGU9	G3GUW3	Androgen receptor.	Progesterone receptor.	0.742
Ar	I79_001744	G3IGU9	G3GVK5	Androgen receptor.	Nuclear receptor corepressor 1.	0.734
Ar	I79_005358	G3IGU9	G3H4Z4	Androgen receptor.	Estrogen receptor beta.	0.597
Ar	I79_006966	G3IGU9	G3H9A0	Androgen receptor.	Mineralocorticoid receptor.	0.493
Ar	I79_019286	G3IGU9	G3I705	Androgen receptor.	Androgen receptor.	0.915
Ar	Med1	G3IGU9	G3H5X2	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.485
Ar	Ncor1	G3IGU9	G3GVK4	Androgen receptor.	Nuclear receptor corepressor 1.	0.734
Ar	Ncor2	G3IGU9	G3HX52	Androgen receptor.	Nuclear receptor corepressor 2.	0.760
Ar	Nr3c1	G3IGU9	G3HEK6	Androgen receptor.	Glucocorticoid receptor.	0.579
Ar	Nr3c2	G3IGU9	G3H999	Androgen receptor.	Mineralocorticoid receptor.	0.440
Esr1	Ar	G3GU19	G3IGU9	Estrogen receptor.	Androgen receptor.	0.893
Esr1	Esrra	G3GU19	G3I885	Estrogen receptor.	Steroid hormone receptor ERR1.	0.411
Esr1	Hnf4a	G3GU19	G3I0S8	Estrogen receptor.	Hepatocyte nuclear factor 4-alpha.	0.426
Esr1	I79_001487	G3GU19	G3GUW3	Estrogen receptor.	Progesterone receptor.	0.990
Esr1	I79_001744	G3GU19	G3GVK5	Estrogen receptor.	Nuclear receptor corepressor 1.	0.824
Esr1	I79_005358	G3GU19	G3H4Z4	Estrogen receptor.	Estrogen receptor beta.	0.963
Esr1	I79_019286	G3GU19	G3I705	Estrogen receptor.	Androgen receptor.	0.833
Esr1	Med1	G3GU19	G3H5X2	Estrogen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.990
Esr1	Ncor1	G3GU19	G3GVK4	Estrogen receptor.	Nuclear receptor corepressor 1.	0.981