(37 nodes) VEGFR2 mediated vascular permeability network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CgPICR_017756	Calmodulin-like protein; Belongs to the calmodulin family. (98 aa)
	I79_015685	EF-hand domain-containing protein. (101 aa)
	Akt3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	Pak3	Non-specific serine/threonine protein kinase. (544 aa)
	I79_017572	Target of rapamycin complex 2 subunit MAPKAP1. (140 aa)
	Kctd5	3-phosphoinositide-dependent protein kinase 1; Belongs to the peptidase S1 family. (799 aa)
	I79_020316	Guanine nucleotide exchange factor VAV3. (604 aa)
	I79_018847	Calmodulin; Belongs to the calmodulin family. (152 aa)
	Mapkap1	Target of rapamycin complex 2 subunit MAPKAP1. (316 aa)
	Trib3	Tribbles-like 3. (353 aa)
	Stpg4	Calmodulin; Belongs to the calmodulin family. (211 aa)
	Vav2	Guanine nucleotide exchange factor VAV2. (453 aa)
	I79_023998	Guanine nucleotide exchange factor VAV2. (93 aa)
	Prr5	Protor-1. (343 aa)
	I79_022271	Ras-related C3 botulinum toxin substrate 2. (178 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	Stx7	Syntaxin-7; Belongs to the syntaxin family. (261 aa)
	I79_020786	Calmodulin; Belongs to the calmodulin family. (141 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	Stx12	Syntaxin-12; Belongs to the syntaxin family. (274 aa)
	Rac1	Ras-related C3 botulinum toxin substrate 1. (148 aa)
	Pak2	Non-specific serine/threonine protein kinase. (524 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Cdh5	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (763 aa)
	Calm2	Calmodulin; Belongs to the calmodulin family. (161 aa)
	Mlst8	Target of rapamycin complex subunit LST8. (326 aa)
	I79_008231	Proto-oncogene vav. (879 aa)
	Arvcf	Armadillo repeat protein deleted in velo-cardio-facial syndrome-like. (730 aa)
	I79_009837	Rapamycin-insensitive companion of mTOR. (1308 aa)
	Jup	Junction plakoglobin. (1148 aa)
	Akt2	Non-specific serine/threonine protein kinase. (200 aa)
	I79_024372	Guanine nucleotide exchange factor VAV2. (233 aa)
	Pak1	Serine/threonine-protein kinase PAK 1. (325 aa)
	I79_024941	Calmodulin; Belongs to the calmodulin family. (149 aa)
	Ctnnd1	Catenin delta-1. (932 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	Akt2	G3H397	G3HNQ3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.969
Akt1	Akt3	G3H397	G3HY42	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.935
Akt1	Cav1	G3H397	G3H9I8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.595
Akt1	Ctnnb1	G3H397	G3H996	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Catenin beta-1.	0.790
Akt1	I79_007693	G3H397	G3HB72	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.835
Akt1	I79_008231	G3H397	G3HCM0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Proto-oncogene vav.	0.641
Akt1	I79_009837	G3H397	G3HGU6	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Rapamycin-insensitive companion of mTOR.	0.953
Akt1	I79_017572	G3H397	G3I2E2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Target of rapamycin complex 2 subunit MAPKAP1.	0.738
Akt1	I79_020316	G3H397	G3I9R0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Guanine nucleotide exchange factor VAV3.	0.636
Akt1	I79_022271	G3H397	G3IEW6	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras-related C3 botulinum toxin substrate 2.	0.517
Akt1	Jup	G3H397	G3HLU9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Junction plakoglobin.	0.531
Akt1	Kctd5	G3H397	G3I2T9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide-dependent protein kinase 1; Belongs to the peptidase S1 family.	0.958
Akt1	Mapkap1	G3H397	G3I8R3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Target of rapamycin complex 2 subunit MAPKAP1.	0.738
Akt1	Mlst8	G3H397	G3HBR5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Target of rapamycin complex subunit LST8.	0.756
Akt1	Mtor	G3H397	G3IEE8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.994
Akt1	Pak1	G3H397	G3ILW0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PAK 1.	0.808
Akt1	Pak3	G3H397	G3HZH7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.462
Akt1	Rac1	G3H397	G3GVB5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras-related C3 botulinum toxin substrate 1.	0.517
Akt1	Trib3	G3H397	G3I900	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tribbles-like 3.	0.984
Akt2	Akt1	G3HNQ3	G3H397	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.969