(39 nodes) Downstream signaling of activated FGFR3 network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_025453	GTPase ERas. (177 aa)
	I79_025505	GTPase ERas. (96 aa)
	Shc1	SHC-transforming protein 1. (579 aa)
	I79_006679	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
	Kras	GTPase KRas. (155 aa)
	I79_004244	Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
	CgPICR_012052	Growth factor receptor-bound protein 2. (217 aa)
	Fgf23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	Fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (350 aa)
	H671_4g12632	GTPase ERas-like protein. (144 aa)
	I79_003162	GTPase ERas. (106 aa)
	I79_025571	GTPase ERas. (155 aa)
	I79_025579	GTPase ERas. (260 aa)
	CgPICR_023615	GTPase ERas. (137 aa)
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	I79_010806	Cold shock domain-containing protein E1. (255 aa)
	Fgfr3	Fibroblast growth factor receptor 3. (319 aa)
	Csde1	Cold shock domain-containing protein E1. (95 aa)
	Eras	GTPase ERas. (228 aa)
	Fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
	Nras	Cold shock domain-containing protein E1. (451 aa)
	I79_014706	GTPase ERas. (126 aa)
	Plcg1	Phosphoinositide phospholipase C. (1217 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	Frs2	Fibroblast growth factor receptor substrate 2. (509 aa)
	Frs3	Fibroblast growth factor receptor substrate 3. (492 aa)
	Pik3ca	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
	H671_1g1070	Fibroblast growth factor 5-like protein; Belongs to the heparin-binding growth factors family. (239 aa)
	I79_017306	GTPase ERas. (167 aa)
	Hras	GTPase HRas-like protein. (189 aa)
	Fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	I79_020221	GTPase ERas. (151 aa)
	I79_020968	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
	I79_020969	Fibroblast growth factor 18. (85 aa)
	CgPICR_020372	GTPase ERas. (182 aa)
	I79_025218	GTPase ERas. (178 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CgPICR_012052	CgPICR_020372	G3GTE4	G3IL61	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	CgPICR_023615	G3GTE4	G3IP24	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	Csde1	G3GTE4	G3HKJ4	Growth factor receptor-bound protein 2.	Cold shock domain-containing protein E1.	0.508
CgPICR_012052	Eras	G3GTE4	G3HND1	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	Fgf1	G3GTE4	G3HEK8	Growth factor receptor-bound protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.630
CgPICR_012052	Fgf16	G3GTE4	G3HNX9	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
CgPICR_012052	Fgf17	G3GTE4	G3GUX3	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.523
CgPICR_012052	Fgf20	G3GTE4	G3GZC6	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
CgPICR_012052	Fgf23	G3GTE4	G3GUK1	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.559
CgPICR_012052	Fgf4	G3GTE4	G3I4D8	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.630
CgPICR_012052	Fgfr3	G3GTE4	G3HK77	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor 3.	0.732
CgPICR_012052	Frs2	G3GTE4	G3HZ39	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor substrate 2.	0.986
CgPICR_012052	Frs3	G3GTE4	G3I108	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor substrate 3.	0.901
CgPICR_012052	H671_1g1070	G3GTE4	G3I1L3	Growth factor receptor-bound protein 2.	Fibroblast growth factor 5-like protein; Belongs to the heparin-binding growth factors family.	0.548
CgPICR_012052	H671_4g12632	G3GTE4	G3GYG7	Growth factor receptor-bound protein 2.	GTPase ERas-like protein.	0.508
CgPICR_012052	Hras	G3GTE4	G3I3F4	Growth factor receptor-bound protein 2.	GTPase HRas-like protein.	0.838
CgPICR_012052	I79_003162	G3GTE4	G3GZA2	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	I79_004244	G3GTE4	G3H277	Growth factor receptor-bound protein 2.	Tyrosine-protein phosphatase non-receptor type 11.	0.992
CgPICR_012052	I79_006679	G3GTE4	G3H8H9	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
CgPICR_012052	I79_010806	G3GTE4	G3HJG1	Growth factor receptor-bound protein 2.	Cold shock domain-containing protein E1.	0.508