(34 nodes) Negative regulation of FGFR4 signaling network (Cricetulus griseus)

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Your Input:
	I79_009500	Mitogen-activated protein kinase 1. (68 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	I79_006679	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
	Fndc3b	Fibronectin type III domain-containing protein 3B. (1203 aa)
	Ppp2cb	Serine/threonine-protein phosphatase. (356 aa)
	I79_004339	Serine/threonine-protein phosphatase. (244 aa)
	I79_004244	Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
	I79_003906	Fibroblast growth factor receptor 4. (1040 aa)
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	Mknk1	MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (415 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (350 aa)
	I79_001364	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	Fgf23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	CgPICR_012052	Growth factor receptor-bound protein 2. (217 aa)
	Frs2	Fibroblast growth factor receptor substrate 2. (509 aa)
	Fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
	Ppp2r1a	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (534 aa)
	Ubc	Ubiquitin. (430 aa)
	Ppp2ca	Serine/threonine-protein phosphatase. (303 aa)
	Mapk3	Mitogen-activated protein kinase. (408 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	Fgf19	Fibroblast growth factor 15; Belongs to the heparin-binding growth factors family. (115 aa)
	I79_020968	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
	I79_020969	Fibroblast growth factor 18. (85 aa)
	Klb	Beta-klotho; Belongs to the glycosyl hydrolase 1 family. (730 aa)
	I79_025158	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform. (65 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	Fndc3a	Fibronectin type-III domain-containing protein 3a. (1133 aa)
	I79_012489	Fibronectin type III domain containing 3c. (548 aa)
	Fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
	I79_011725	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (249 aa)
	Spry2	Protein sprouty-like 2. (316 aa)
	I79_009740	B-Raf proto-oncogene serine/threonine-protein kinase. (229 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CgPICR_012052	Fgf1	G3GTE4	G3HEK8	Growth factor receptor-bound protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.630
CgPICR_012052	Fgf16	G3GTE4	G3HNX9	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
CgPICR_012052	Fgf17	G3GTE4	G3GUX3	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.523
CgPICR_012052	Fgf19	G3GTE4	G3I4D9	Growth factor receptor-bound protein 2.	Fibroblast growth factor 15; Belongs to the heparin-binding growth factors family.	0.568
CgPICR_012052	Fgf20	G3GTE4	G3GZC6	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
CgPICR_012052	Fgf23	G3GTE4	G3GUK1	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.559
CgPICR_012052	Fgf4	G3GTE4	G3I4D8	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.630
CgPICR_012052	Frs2	G3GTE4	G3HZ39	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor substrate 2.	0.986
CgPICR_012052	I79_001364	G3GTE4	G3GUK2	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.481
CgPICR_012052	I79_003906	G3GTE4	G3H181	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor 4.	0.682
CgPICR_012052	I79_004244	G3GTE4	G3H277	Growth factor receptor-bound protein 2.	Tyrosine-protein phosphatase non-receptor type 11.	0.992
CgPICR_012052	I79_004339	G3GTE4	G3H2D0	Growth factor receptor-bound protein 2.	Serine/threonine-protein phosphatase.	0.452
CgPICR_012052	I79_006679	G3GTE4	G3H8H9	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
CgPICR_012052	I79_009500	G3GTE4	G3HFY3	Growth factor receptor-bound protein 2.	Mitogen-activated protein kinase 1.	0.461
CgPICR_012052	I79_009740	G3GTE4	G3HGK2	Growth factor receptor-bound protein 2.	B-Raf proto-oncogene serine/threonine-protein kinase.	0.485
CgPICR_012052	I79_019149	G3GTE4	G3I6M4	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
CgPICR_012052	I79_020968	G3GTE4	G3IBE8	Growth factor receptor-bound protein 2.	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family.	0.656
CgPICR_012052	I79_020969	G3GTE4	G3IBE9	Growth factor receptor-bound protein 2.	Fibroblast growth factor 18.	0.606
CgPICR_012052	I79_025158	G3GTE4	G3IML8	Growth factor receptor-bound protein 2.	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform.	0.452
CgPICR_012052	Klb	G3GTE4	G3ILP5	Growth factor receptor-bound protein 2.	Beta-klotho; Belongs to the glycosyl hydrolase 1 family.	0.459