(64 nodes) Signaling by FGFR1 network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Flrt2	Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
	CgPICR_012052	Growth factor receptor-bound protein 2. (217 aa)
	Fgf23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	I79_001364	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	Fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (350 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	H671_4g12632	GTPase ERas-like protein. (144 aa)
	Mknk1	MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (415 aa)
	I79_003162	GTPase ERas. (106 aa)
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	Spred2	Sprouty-related, EVH1 domain-containing protein 2. (415 aa)
	I79_004031	Fibroblast growth factor receptor. (731 aa)
	I79_004244	Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
	I79_004339	Serine/threonine-protein phosphatase. (244 aa)
	Kras	GTPase KRas. (155 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
	Ppp2cb	Serine/threonine-protein phosphatase. (356 aa)
	Fndc3b	Fibronectin type III domain-containing protein 3B. (1203 aa)
	I79_006679	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
	Shc1	SHC-transforming protein 1. (579 aa)
	Fgfrl1	Fibroblast growth factor receptor-like 1. (503 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	Fgf22	Fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (70 aa)
	I79_009500	Mitogen-activated protein kinase 1. (68 aa)
	I79_009740	B-Raf proto-oncogene serine/threonine-protein kinase. (229 aa)
	Spry2	Protein sprouty-like 2. (316 aa)
	Spred1	Sprouty-related, EVH1 domain-containing protein 1. (370 aa)
	I79_010806	Cold shock domain-containing protein E1. (255 aa)
	Csde1	Cold shock domain-containing protein E1. (95 aa)
	I79_011725	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (249 aa)
	Kl	Klotho. (900 aa)
	Eras	GTPase ERas. (228 aa)
	I79_012489	Fibronectin type III domain containing 3c. (548 aa)
	Nras	Cold shock domain-containing protein E1. (451 aa)
	Fndc3a	Fibronectin type-III domain-containing protein 3a. (1133 aa)
	I79_014706	GTPase ERas. (126 aa)
	Plcg1	Phosphoinositide phospholipase C. (1217 aa)
	Flrt3	Leucine-rich repeat transmembrane protein FLRT3. (649 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	Frs2	Fibroblast growth factor receptor substrate 2. (509 aa)
	Ppp2ca	Serine/threonine-protein phosphatase. (303 aa)
	Frs3	Fibroblast growth factor receptor substrate 3. (492 aa)
	Ubc	Ubiquitin. (430 aa)
	Pik3ca	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
	H671_1g1070	Fibroblast growth factor 5-like protein; Belongs to the heparin-binding growth factors family. (239 aa)
	I79_017306	GTPase ERas. (167 aa)
	Ppp2r1a	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (534 aa)
	Hras	GTPase HRas-like protein. (189 aa)
	Fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
	Fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
	Mapk3	Mitogen-activated protein kinase. (408 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	Flrt1	Leucine-rich repeat transmembrane protein FLRT1. (674 aa)
	I79_020221	GTPase ERas. (151 aa)
	I79_020968	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
	I79_020969	Fibroblast growth factor 18. (85 aa)
	CgPICR_020372	GTPase ERas. (182 aa)
	I79_025158	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform. (65 aa)
	I79_025218	GTPase ERas. (178 aa)
	I79_025453	GTPase ERas. (177 aa)
	I79_025505	GTPase ERas. (96 aa)
	I79_025571	GTPase ERas. (155 aa)
	I79_025579	GTPase ERas. (260 aa)
	CgPICR_023615	GTPase ERas. (137 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CgPICR_012052	CgPICR_020372	G3GTE4	G3IL61	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	CgPICR_023615	G3GTE4	G3IP24	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	Csde1	G3GTE4	G3HKJ4	Growth factor receptor-bound protein 2.	Cold shock domain-containing protein E1.	0.508
CgPICR_012052	Eras	G3GTE4	G3HND1	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	Fgf1	G3GTE4	G3HEK8	Growth factor receptor-bound protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.630
CgPICR_012052	Fgf17	G3GTE4	G3GUX3	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.523
CgPICR_012052	Fgf20	G3GTE4	G3GZC6	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
CgPICR_012052	Fgf22	G3GTE4	G3HF41	Growth factor receptor-bound protein 2.	Fibroblast growth factor 22; Belongs to the heparin-binding growth factors family.	0.571
CgPICR_012052	Fgf23	G3GTE4	G3GUK1	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.559
CgPICR_012052	Fgf3	G3GTE4	G3I4D7	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.585
CgPICR_012052	Fgf4	G3GTE4	G3I4D8	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.630
CgPICR_012052	Fgfrl1	G3GTE4	G3HEF1	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor-like 1.	0.648
CgPICR_012052	Frs2	G3GTE4	G3HZ39	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor substrate 2.	0.986
CgPICR_012052	Frs3	G3GTE4	G3I108	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor substrate 3.	0.901
CgPICR_012052	H671_1g1070	G3GTE4	G3I1L3	Growth factor receptor-bound protein 2.	Fibroblast growth factor 5-like protein; Belongs to the heparin-binding growth factors family.	0.548
CgPICR_012052	H671_4g12632	G3GTE4	G3GYG7	Growth factor receptor-bound protein 2.	GTPase ERas-like protein.	0.508
CgPICR_012052	Hras	G3GTE4	G3I3F4	Growth factor receptor-bound protein 2.	GTPase HRas-like protein.	0.838
CgPICR_012052	I79_001364	G3GTE4	G3GUK2	Growth factor receptor-bound protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.481
CgPICR_012052	I79_003162	G3GTE4	G3GZA2	Growth factor receptor-bound protein 2.	GTPase ERas.	0.508
CgPICR_012052	I79_004031	G3GTE4	G3H1K2	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor.	0.648