(104 nodes) Assembly of the pre-replicative complex network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Psmc2	26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (410 aa)
	Cdt1	DNA replication factor Cdt1. (553 aa)
	Mcm8	DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa)
	I79_000636	Transmembrane 4 L6 family member 19. (226 aa)
	Psmd11	26S proteasome non-ATPase regulatory subunit 11. (263 aa)
	Orc1	Origin recognition complex subunit 1. (817 aa)
	Psma7	Proteasome endopeptidase complex. (212 aa)
	I79_002297	Protein FAM89A. (86 aa)
	Anapc11	Anaphase-promoting complex subunit 11. (88 aa)
	Psmb6	Proteasome subunit beta type-6. (110 aa)
	Psmc3	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (265 aa)
	I79_003329	Cell division cycle protein 16-like. (453 aa)
	I79_003456	Anaphase-promoting complex subunit 1. (1769 aa)
	Psma4	Proteasome subunit alpha type. (261 aa)
	Ube2e2	Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (155 aa)
	I79_003977	Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
	Anapc7	Anaphase-promoting complex subunit 7. (565 aa)
	Camkk2	Anaphase-promoting complex subunit 5. (1188 aa)
	Psmd9	26S proteasome non-ATPase regulatory subunit 9. (222 aa)
	Psmd4	26S proteasome non-ATPase regulatory subunit 4. (380 aa)
	I79_019105	26S protease regulatory subunit S10B. (284 aa)
	Mcm9	DNA replication licensing factor MCM9; Belongs to the MCM family. (893 aa)
	I79_018405	Histone H2B type F-M; Belongs to the histone H2B family. (138 aa)
	I79_018217	Histone H2B type 2-F; Belongs to the histone H2B family. (73 aa)
	Psma6	Proteasome endopeptidase complex. (164 aa)
	Psmd2	26S proteasome non-ATPase regulatory subunit 2. (657 aa)
	I79_017808	26S proteasome non-ATPase regulatory subunit 2. (91 aa)
	Mcm4	DNA helicase; Belongs to the MCM family. (862 aa)
	Anapc16	UPF0448 protein C10orf104-like. (110 aa)
	Mcm3	DNA helicase; Belongs to the MCM family. (807 aa)
	Psmd14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	Ubc	Ubiquitin. (430 aa)
	Psmd7	26S proteasome non-ATPase regulatory subunit 7. (320 aa)
	Orc4	Origin recognition complex subunit 4. (105 aa)
	CgPICR_012534	Proteasome activator complex subunit 1. (85 aa)
	Psme1	Proteasome activator complex subunit 1. (130 aa)
	Fzr1	Fizzy-related protein-like. (493 aa)
	Psma2	Proteasome subunit alpha type. (234 aa)
	Psma1	Proteasome subunit alpha type. (263 aa)
	I79_013774	Proteasome subunit beta type-3. (95 aa)
	Psmb5	Proteasome subunit beta. (263 aa)
	Psmb8	Proteasome subunit beta. (228 aa)
	Psmb9	Proteasome subunit beta. (219 aa)
	Psmb1	Proteasome subunit beta type-1. (140 aa)
	Psmc4	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (409 aa)
	Psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	I79_005093	UPF0459 protein C19orf50-like. (207 aa)
	Ube2d1	Ubiquitin-conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (110 aa)
	I79_005256	Uncharacterized protein. (224 aa)
	I79_005692	Importin subunit beta-1. (1894 aa)
	Psmb3	Proteasome subunit beta. (194 aa)
	Psmf1	Proteasome inhibitor PI31 subunit. (271 aa)
	Mcm2	DNA helicase; Belongs to the MCM family. (905 aa)
	Kpna6	Importin subunit alpha; Functions in nuclear protein import. (536 aa)
	Anapc10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	Psmb2	Proteasome subunit beta. (201 aa)
	I79_007551	Proteasome activator complex subunit 1. (133 aa)
	I79_007793	26S protease regulatory subunit 4. (477 aa)
	I79_007977	Uncharacterized protein C11orf51-like. (124 aa)
	Psmd12	26S proteasome non-ATPase regulatory subunit 12. (456 aa)
	I79_008315	26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (423 aa)
	Psme2	Proteasome activator complex subunit 2. (239 aa)
	I79_008549	Proteasome activator complex subunit 1. (215 aa)
	I79_008560	Cell division cycle protein 27-like. (182 aa)
	I79_008690	Histone H2B; Belongs to the histone H2B family. (67 aa)
	Gmnn	Geminin. (202 aa)
	Gfra3	Cell division cycle protein 23-like. (668 aa)
	Cdc27	Cell division cycle protein 27-like. (316 aa)
	Cdc26	Anaphase-promoting complex subunit CDC26. (129 aa)
	Psmd6	26S proteasome non-ATPase regulatory subunit 6. (389 aa)
	Orc3	Origin recognition complex subunit 3. (303 aa)
	Psmd8	26S proteasome non-ATPase regulatory subunit 8. (183 aa)
	I79_010992	Histone H2B type 1; Belongs to the histone H2B family. (126 aa)
	Psmb10	Proteasome subunit beta. (273 aa)
	Ube2c	Ubiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (191 aa)
	Psme3	Proteasome activator complex subunit 3. (254 aa)
	Fam89a	Protein FAM89A. (70 aa)
	I79_019666	Tetratricopeptide repeat protein 6. (694 aa)
	Anapc4	Anaphase-promoting complex subunit 4. (553 aa)
	I79_019705	Anaphase-promoting complex subunit 4. (253 aa)
	Orc6	Origin recognition complex subunit 6. (252 aa)
	Psmb7	Proteasome subunit beta. (277 aa)
	I79_020214	Proteasome subunit alpha type. (269 aa)
	Mcm5	DNA helicase; Belongs to the MCM family. (734 aa)
	CgPICR_009887	Histone H2B; Belongs to the histone H2B family. (126 aa)
	Psmd10	26S proteasome non-ATPase regulatory subunit 10. (218 aa)
	Anapc2	Anaphase-promoting complex subunit 2; Belongs to the cullin family. (269 aa)
	Fam89b	Protein FAM89B. (85 aa)
	Orc2	Origin recognition complex subunit 2. (576 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
	Orc5	Origin recognition complex subunit 5. (435 aa)
	I79_026095	Proteasome subunit beta type-3. (52 aa)
	I79_026038	26S proteasome non-ATPase regulatory subunit 3. (190 aa)
	I79_025902	DNA replication licensing factor MCM2. (182 aa)
	Psmd13	26S proteasome non-ATPase regulatory subunit 13. (273 aa)
	I79_024971	26S proteasome non-ATPase regulatory subunit 1. (539 aa)
	I79_024894	26S proteasome non-ATPase regulatory subunit 13. (99 aa)
	I79_024849	26S proteasome non-ATPase regulatory subunit 5. (461 aa)
	I79_024753	26S proteasome non-ATPase regulatory subunit 3. (163 aa)
	I79_024752	26S proteasome non-ATPase regulatory subunit 3. (119 aa)
	I79_024743	26S proteasome non-ATPase regulatory subunit 1. (309 aa)
	I79_024248	Importin subunit alpha; Functions in nuclear protein import. (538 aa)
	I79_023697	Proteasome activator complex subunit 3. (107 aa)
	H671_3g8564	Uncharacterized protein C11orf51-like. (132 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Anapc10	Anapc11	G3H9G3	G3GXB2	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase-promoting complex subunit 11.	0.999
Anapc10	Anapc16	G3H9G3	G3I1Z2	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	UPF0448 protein C10orf104-like.	0.996
Anapc10	Anapc2	G3H9G3	G3IG37	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.999
Anapc10	Anapc4	G3H9G3	G3I846	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase-promoting complex subunit 4.	0.996
Anapc10	Anapc7	G3H9G3	G3H237	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase-promoting complex subunit 7.	0.999
Anapc10	CDC6	G3H9G3	Q6RUG6	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.805
Anapc10	Camkk2	G3H9G3	G3H244	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase-promoting complex subunit 5.	0.998
Anapc10	Cdc26	G3H9G3	G3HI04	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase-promoting complex subunit CDC26.	0.999
Anapc10	Cdc27	G3H9G3	G3HGD0	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle protein 27-like.	0.996
Anapc10	Cdt1	G3H9G3	G3GRT1	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	DNA replication factor Cdt1.	0.503
Anapc10	Fam89a	G3H9G3	G3HM45	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Protein FAM89A.	0.900
Anapc10	Fam89b	G3H9G3	G3IGT6	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Protein FAM89B.	0.900
Anapc10	Fzr1	G3H9G3	G3HSJ7	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Fizzy-related protein-like.	0.987
Anapc10	Gfra3	G3H9G3	G3HEZ7	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle protein 23-like.	0.998
Anapc10	H671_3g8564	G3H9G3	G3II16	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Uncharacterized protein C11orf51-like.	0.971
Anapc10	I79_002297	G3H9G3	G3GX10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Protein FAM89A.	0.900
Anapc10	I79_003329	G3H9G3	G3GZN8	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle protein 16-like.	0.998
Anapc10	I79_003456	G3H9G3	G3H008	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase-promoting complex subunit 1.	0.999
Anapc10	I79_003977	G3H9G3	G3H1F2	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family.	0.693
Anapc10	I79_007793	G3H9G3	G3HBG5	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	26S protease regulatory subunit 4.	0.588