(20 nodes) NOTCH3 Activation and Transmission of Signal to the Nucleus network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	Wwp2	E3 ubiquitin-protein ligase. (870 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	I79_011804	Neurogenic locus notch-like protein 3. (2181 aa)
	I79_005386	Gamma-secretase subunit APH-1B. (196 aa)
	Ncstn	Nicastrin. (615 aa)
	Ybx1	Nuclease-sensitive element-binding protein 1. (127 aa)
	I79_021564	Pro-epidermal growth factor. (699 aa)
	I79_005385	Gamma-secretase subunit APH-1B. (219 aa)
	Dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (578 aa)
	Ubc	Ubiquitin. (430 aa)
	Adam10	Disintegrin and metalloproteinase domain-containing protein 10. (675 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	Aph1a	Gamma-secretase subunit APH-1A. (247 aa)
	I79_004721	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1234 aa)
	I79_007126	E3 ubiquitin-protein ligase NEURL1B. (286 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	I79_009702	E3 ubiquitin-protein ligase MIB1. (739 aa)
	I79_011096	Transforming acidic coiled-coil-containing protein 3. (580 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam10	Aph1a	G3GRM2	G3H2V5	Disintegrin and metalloproteinase domain-containing protein 10.	Gamma-secretase subunit APH-1A.	0.540
Adam10	Dll1	G3GRM2	G3HNT7	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.698
Adam10	Dll4	G3GRM2	G3ICK3	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.523
Adam10	I79_004721	G3GRM2	G3H3A6	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.474
Adam10	I79_011804	G3GRM2	G3HM56	Disintegrin and metalloproteinase domain-containing protein 10.	Neurogenic locus notch-like protein 3.	0.442
Adam10	I79_021564	G3GRM2	G3ID03	Disintegrin and metalloproteinase domain-containing protein 10.	Pro-epidermal growth factor.	0.465
Adam10	Jag1	G3GRM2	G3GSA7	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.553
Adam10	Ncstn	G3GRM2	G3H7X9	Disintegrin and metalloproteinase domain-containing protein 10.	Nicastrin.	0.847
Adam10	Psen1	G3GRM2	G3HNF2	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.781
Adam10	Psen2	G3GRM2	G3HV76	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.719
Aph1a	Adam10	G3H2V5	G3GRM2	Gamma-secretase subunit APH-1A.	Disintegrin and metalloproteinase domain-containing protein 10.	0.540
Aph1a	Ncstn	G3H2V5	G3H7X9	Gamma-secretase subunit APH-1A.	Nicastrin.	0.999
Aph1a	Psen1	G3H2V5	G3HNF2	Gamma-secretase subunit APH-1A.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
Aph1a	Psen2	G3H2V5	G3HV76	Gamma-secretase subunit APH-1A.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
Dll1	Adam10	G3HNT7	G3GRM2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Disintegrin and metalloproteinase domain-containing protein 10.	0.698
Dll1	Dll4	G3HNT7	G3ICK3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll1	I79_009702	G3HNT7	G3HGH5	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	E3 ubiquitin-protein ligase MIB1.	0.466
Dll1	I79_011804	G3HNT7	G3HM56	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 3.	0.888
Dll1	Jag1	G3HNT7	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
Dll1	Psen1	G3HNT7	G3HNF2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.481