(58 nodes) Interleukin receptor SHC signaling network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_005111	Phosphatidylinositol 3-kinase regulatory subunit beta. (653 aa)
	I79_000583	GRB2-associated-binding protein 2. (123 aa)
	I79_000590	GRB2-associated-binding protein 2. (197 aa)
	CgPICR_012052	Growth factor receptor-bound protein 2. (217 aa)
	CgPICR_003432	GRB2-associated-binding protein 2. (186 aa)
	Ptpn6	Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
	I79_001850	GRB2-associated-binding protein 2. (142 aa)
	I79_001940	GRB2-associated-binding protein 2. (135 aa)
	I79_002944	Phosphatidylinositol 3-kinase regulatory subunit gamma. (460 aa)
	Il5ra	Interleukin-5 receptor subunit alpha. (396 aa)
	I79_004979	GRB2-associated-binding protein 2. (97 aa)
	I79_005129	Tyrosine-protein kinase JAK3. (330 aa)
	Jak3	Tyrosine-protein kinase JAK3. (222 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
	Csf2	Granulocyte-macrophage colony-stimulating factor. (95 aa)
	Shc1	SHC-transforming protein 1. (579 aa)
	I79_008814	GRB2-associated-binding protein 2. (88 aa)
	I79_008997	GRB2-associated-binding protein 2. (265 aa)
	I79_009115	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
	I79_009116	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
	I79_010199	GRB2-associated-binding protein 2. (173 aa)
	I79_010317	GRB2-associated-binding protein 2. (234 aa)
	I79_010890	GRB2-associated-binding protein 2. (92 aa)
	I79_011625	GRB2-associated-binding protein 2. (115 aa)
	CgPICR_020133	GRB2-associated-binding protein 2. (360 aa)
	H671_7g17291	GRB2-associated-binding protein 2. (86 aa)
	I79_013974	GRB2-associated-binding protein 2. (173 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	I79_015257	GRB2-associated-binding protein 2. (138 aa)
	Jak1	Tyrosine-protein kinase. (1140 aa)
	Pik3ca	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
	I79_017790	GRB2-associated-binding protein 2. (154 aa)
	I79_019065	GRB2-associated-binding protein 2. (142 aa)
	I79_019131	GRB2-associated-binding protein 2. (83 aa)
	I79_019326	GRB2-associated-binding protein 2. (159 aa)
	Pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (910 aa)
	CgPICR_008423	GRB2-associated-binding protein 2. (103 aa)
	CUNHXorf65	Cytokine receptor common gamma chain. (456 aa)
	I79_020792	GRB2-associated-binding protein 2. (133 aa)
	Gab2	GRB2-associated-binding protein 2. (485 aa)
	I79_021408	GRB2-associated-binding protein 2. (129 aa)
	Inppl1	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2. (1253 aa)
	CgPICR_007800	GRB2-associated-binding protein 2. (126 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	I79_023364	Cytokine receptor common subunit beta. (710 aa)
	Inpp5d	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1. (91 aa)
	I79_024157	GRB2-associated-binding protein 2. (161 aa)
	I79_024224	GRB2-associated-binding protein 2. (117 aa)
	I79_024980	GRB2-associated-binding protein 2. (88 aa)
	H671_6g15462	GRB2-associated-binding protein 2. (144 aa)
	I79_025089	GRB2-associated-binding protein 2. (517 aa)
	I79_025313	Cytokine receptor common subunit beta. (71 aa)
	I79_025434	Interleukin-3 receptor class 2 beta chain. (355 aa)
	I79_025528	GRB2-associated-binding protein 2. (137 aa)
	I79_025563	GRB2-associated-binding protein 2. (142 aa)
	I79_025584	Interleukin-2 receptor subunit beta. (202 aa)
	I79_025621	GRB2-associated-binding protein 2. (367 aa)
	I79_025973	GRB2-associated-binding protein 2. (116 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUNHXorf65	I79_005129	G3I7K3	G3H4C8	Cytokine receptor common gamma chain.	Tyrosine-protein kinase JAK3.	0.838
CUNHXorf65	I79_025584	G3I7K3	G3INQ3	Cytokine receptor common gamma chain.	Interleukin-2 receptor subunit beta.	0.986
CUNHXorf65	IL2	G3I7K3	G3HTL8	Cytokine receptor common gamma chain.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.958
CUNHXorf65	Inppl1	G3I7K3	G3ICV1	Cytokine receptor common gamma chain.	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2.	0.404
CUNHXorf65	Jak1	G3I7K3	G3HY52	Cytokine receptor common gamma chain.	Tyrosine-protein kinase.	0.869
CUNHXorf65	Jak2	G3I7K3	G3IEQ4	Cytokine receptor common gamma chain.	Tyrosine-protein kinase.	0.766
CUNHXorf65	Jak3	G3I7K3	G3H4C9	Cytokine receptor common gamma chain.	Tyrosine-protein kinase JAK3.	0.838
CUNHXorf65	Ptpn6	G3I7K3	G3GUQ5	Cytokine receptor common gamma chain.	Tyrosine-protein phosphatase non-receptor type 6.	0.460
CgPICR_003432	I79_015257	G3GTT8	G3HWA4	GRB2-associated-binding protein 2.	GRB2-associated-binding protein 2.	0.574
CgPICR_007800	I79_001940	G3IDB2	G3GW29	GRB2-associated-binding protein 2.	GRB2-associated-binding protein 2.	0.522
CgPICR_007800	I79_010199	G3IDB2	G3HHT9	GRB2-associated-binding protein 2.	GRB2-associated-binding protein 2.	0.519
CgPICR_007800	I79_010890	G3IDB2	G3HJP1	GRB2-associated-binding protein 2.	GRB2-associated-binding protein 2.	0.509
CgPICR_007800	I79_020792	G3IDB2	G3IB05	GRB2-associated-binding protein 2.	GRB2-associated-binding protein 2.	0.526
CgPICR_007800	I79_024224	G3IDB2	G3IK28	GRB2-associated-binding protein 2.	GRB2-associated-binding protein 2.	0.511
CgPICR_007800	I79_025973	G3IDB2	G3IPQ4	GRB2-associated-binding protein 2.	GRB2-associated-binding protein 2.	0.508
CgPICR_012052	I79_002944	G3GTE4	G3GYN9	Growth factor receptor-bound protein 2.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.801
CgPICR_012052	I79_005111	G3GTE4	G3H4B1	Growth factor receptor-bound protein 2.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.801
CgPICR_012052	I79_005129	G3GTE4	G3H4C8	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase JAK3.	0.625
CgPICR_012052	I79_009115	G3GTE4	G3HEW7	Growth factor receptor-bound protein 2.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.570
CgPICR_012052	I79_009116	G3GTE4	G3HEW9	Growth factor receptor-bound protein 2.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.570