(14 nodes) (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. network (Cricetulus griseus)

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Your Input:
	I79_017171	Phosphoglycerate kinase. (62 aa)
	Dnase1	Deoxyribonuclease; Belongs to the DNase I family. (284 aa)
	Scai	Protein SCAI. (123 aa)
	I79_015556	Phosphoglycerate kinase. (195 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Pgk1	Phosphoglycerate kinase. (242 aa)
	I79_012485	Phosphoglycerate kinase. (151 aa)
	Il10	Interleukin-10. (178 aa)
	Ctla4	Cytotoxic T-lymphocyte protein 4. (171 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	I79_021181	Phosphoglycerate kinase. (311 aa)
	I79_017713	Deoxyribonuclease; Belongs to the DNase I family. (282 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	Ctla4	G3GUN9	G3GYW4	T-cell surface glycoprotein CD4.	Cytotoxic T-lymphocyte protein 4.	0.962
Cd4	IL2	G3GUN9	G3HTL8	T-cell surface glycoprotein CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.974
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Src	G3GUN9	G3GXX7	T-cell surface glycoprotein CD4.	Tyrosine-protein kinase.	0.840
Ctla4	Cd4	G3GYW4	G3GUN9	Cytotoxic T-lymphocyte protein 4.	T-cell surface glycoprotein CD4.	0.962
Ctla4	IL2	G3GYW4	G3HTL8	Cytotoxic T-lymphocyte protein 4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.891
Ctla4	Ifng	G3GYW4	G3GY20	Cytotoxic T-lymphocyte protein 4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.889
Ctla4	Il10	G3GYW4	G3HB01	Cytotoxic T-lymphocyte protein 4.	Interleukin-10.	0.842
Ctla4	Src	G3GYW4	G3GXX7	Cytotoxic T-lymphocyte protein 4.	Tyrosine-protein kinase.	0.517
I79_012485	Pgk1	G3HNY4	G3HNY5	Phosphoglycerate kinase.	Phosphoglycerate kinase.	0.945
IL2	Cd4	G3HTL8	G3GUN9	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	T-cell surface glycoprotein CD4.	0.974
IL2	Ctla4	G3HTL8	G3GYW4	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Cytotoxic T-lymphocyte protein 4.	0.891
IL2	Ifng	G3HTL8	G3GY20	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
IL2	Il10	G3HTL8	G3HB01	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interleukin-10.	0.947
Ifng	Cd4	G3GY20	G3GUN9	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	T-cell surface glycoprotein CD4.	0.966
Ifng	Ctla4	G3GY20	G3GYW4	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Cytotoxic T-lymphocyte protein 4.	0.889
Ifng	IL2	G3GY20	G3HTL8	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.966
Ifng	Il10	G3GY20	G3HB01	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-10.	0.979
Ifng	Src	G3GY20	G3GXX7	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.522