STRINGSTRING
Gpx1 Gpx1 Ccnd1 Ccnd1 Casp8 Casp8 I79_001600 I79_001600 Gpx7 Gpx7 Fasn Fasn I79_004417 I79_004417 Gpx3 Gpx3 Igf1 Igf1 Mmp9 Mmp9 Dna2 Dna2 Pxdn Pxdn Bcl2 Bcl2 I79_009215 I79_009215 Ccna1 Ccna1 Esco1 Esco1 I79_009796 I79_009796 Igf1r Igf1r Casp2 Casp2 Stat3 Stat3 Hgf Hgf Gpx6 Gpx6 Gpx5 Gpx5 Sod2 Sod2 Top1 Top1 I79_018057 I79_018057 I79_019286 I79_019286 I79_020089 I79_020089 Gpx8 Gpx8 I79_021949 I79_021949 Ar Ar Top1mt Top1mt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gpx1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
FasnFatty acid synthase. (2503 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Gpx3Glutathione peroxidase 3. (53 aa)
Igf1Insulin-like growth factor I. (75 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Dna2DNA2-like helicase. (767 aa)
PxdnPeroxidasin-like. (1475 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
I79_009215Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa)
Ccna1Cyclin-A1; Belongs to the cyclin family. (351 aa)
Esco1N-acetyltransferase ESCO1. (841 aa)
I79_009796Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (697 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
Casp2Caspase-2; Belongs to the peptidase C14A family. (421 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
Gpx6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
Gpx5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (192 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Top1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (715 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
I79_019286Androgen receptor. (295 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
Gpx8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
ArAndrogen receptor. (517 aa)
Top1mtDNA topoisomerase I, mitochondrial. (69 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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