(20 nodes) (2009) Monitoring autophagy in lysosomal storage disorders. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Igf2r	Cation-independent mannose-6-phosphate receptor. (1700 aa)
	Glb1	Beta-galactosidase. (650 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Ctsb	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	Htt	Huntingtin protein. (2928 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
	I79_001093	Beta-galactosidase. (659 aa)
	I79_001092	Beta-galactosidase. (680 aa)
	Cln3	Battenin. (400 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	CgPICR_017737	Lysosome-associated membrane glycoprotein 1. (403 aa)
	Ctsd	Cathepsin D; Belongs to the peptidase A1 family. (408 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	I79_016240	Beclin-1. (119 aa)
	I79_015475	Mucolipin-1. (532 aa)
	I79_015170	Beta-galactosidase. (615 aa)
	Becn1	Beclin-1. (448 aa)
	Lamp1	Lysosome-associated membrane glycoprotein 1. (370 aa)
	I79_010620	Alpha-synuclein; Belongs to the synuclein family. (166 aa)
	Sumf1	Sulfatase-modifying factor 1. (284 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Becn1	CgPICR_017737	G3HLZ1	G3I7Y3	Beclin-1.	Lysosome-associated membrane glycoprotein 1.	0.582
Becn1	Ctsd	G3HLZ1	G3I4W7	Beclin-1.	Cathepsin D; Belongs to the peptidase A1 family.	0.413
Becn1	Htt	G3HLZ1	G3GWA8	Beclin-1.	Huntingtin protein.	0.948
Becn1	I79_001600	G3HLZ1	G3GV69	Beclin-1.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.577
Becn1	I79_004417	G3HLZ1	G3H2K2	Beclin-1.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.577
Becn1	I79_010620	G3HLZ1	G3HIY8	Beclin-1.	Alpha-synuclein; Belongs to the synuclein family.	0.439
Becn1	I79_018057	G3HLZ1	G3I3P7	Beclin-1.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.577
Becn1	Lamp1	G3HLZ1	G3HK56	Beclin-1.	Lysosome-associated membrane glycoprotein 1.	0.582
CgPICR_017737	Becn1	G3I7Y3	G3HLZ1	Lysosome-associated membrane glycoprotein 1.	Beclin-1.	0.582
CgPICR_017737	Cln3	G3I7Y3	G3IK14	Lysosome-associated membrane glycoprotein 1.	Battenin.	0.405
CgPICR_017737	Ctsb	G3I7Y3	G3H0L9	Lysosome-associated membrane glycoprotein 1.	Cathepsin B; Belongs to the peptidase C1 family.	0.664
CgPICR_017737	Ctsd	G3I7Y3	G3I4W7	Lysosome-associated membrane glycoprotein 1.	Cathepsin D; Belongs to the peptidase A1 family.	0.891
CgPICR_017737	I79_015475	G3I7Y3	G3HWW2	Lysosome-associated membrane glycoprotein 1.	Mucolipin-1.	0.469
CgPICR_017737	I79_016240	G3I7Y3	G3HYU8	Lysosome-associated membrane glycoprotein 1.	Beclin-1.	0.551
CgPICR_017737	Igf2r	G3I7Y3	G3HGQ1	Lysosome-associated membrane glycoprotein 1.	Cation-independent mannose-6-phosphate receptor.	0.442
CgPICR_017737	Lamp1	G3I7Y3	G3HK56	Lysosome-associated membrane glycoprotein 1.	Lysosome-associated membrane glycoprotein 1.	0.900
CgPICR_017737	Mtor	G3I7Y3	G3IEE8	Lysosome-associated membrane glycoprotein 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.866
Cln3	CgPICR_017737	G3IK14	G3I7Y3	Battenin.	Lysosome-associated membrane glycoprotein 1.	0.405
Cln3	Ctsd	G3IK14	G3I4W7	Battenin.	Cathepsin D; Belongs to the peptidase A1 family.	0.609
Cln3	Lamp1	G3IK14	G3HK56	Battenin.	Lysosome-associated membrane glycoprotein 1.	0.405