(17 nodes) (2009) Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilingamma-secretase activity. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	L1cam	Neural cell adhesion molecule L1. (1287 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Fyn	Proto-oncogene tyrosine-protein kinase Fyn. (232 aa)
	App	Amyloid beta A4 protein. (433 aa)
	Lamp1	Lysosome-associated membrane glycoprotein 1. (370 aa)
	Hoxa9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (271 aa)
	Pxdn	Peroxidasin-like. (1475 aa)
	I79_007578	Neurofascin. (1279 aa)
	Adam10	Disintegrin and metalloproteinase domain-containing protein 10. (675 aa)
	Ctsb	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	Prnp	Major prion protein; Belongs to the prion family. (254 aa)
	Ncstn	Nicastrin. (615 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	HSPA5	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
	CgPICR_017737	Lysosome-associated membrane glycoprotein 1. (403 aa)
	Msn	Moesin. (293 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam10	App	G3GRM2	G3HMG4	Disintegrin and metalloproteinase domain-containing protein 10.	Amyloid beta A4 protein.	0.739
Adam10	Fyn	G3GRM2	G3HMR9	Disintegrin and metalloproteinase domain-containing protein 10.	Proto-oncogene tyrosine-protein kinase Fyn.	0.431
Adam10	L1cam	G3GRM2	G3HSW5	Disintegrin and metalloproteinase domain-containing protein 10.	Neural cell adhesion molecule L1.	0.450
Adam10	Ncstn	G3GRM2	G3H7X9	Disintegrin and metalloproteinase domain-containing protein 10.	Nicastrin.	0.847
Adam10	Psen1	G3GRM2	G3HNF2	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.781
Adam10	Psen2	G3GRM2	G3HV76	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.719
App	Adam10	G3HMG4	G3GRM2	Amyloid beta A4 protein.	Disintegrin and metalloproteinase domain-containing protein 10.	0.739
App	Ctsb	G3HMG4	G3H0L9	Amyloid beta A4 protein.	Cathepsin B; Belongs to the peptidase C1 family.	0.584
App	Fyn	G3HMG4	G3HMR9	Amyloid beta A4 protein.	Proto-oncogene tyrosine-protein kinase Fyn.	0.519
App	L1cam	G3HMG4	G3HSW5	Amyloid beta A4 protein.	Neural cell adhesion molecule L1.	0.403
App	Ncstn	G3HMG4	G3H7X9	Amyloid beta A4 protein.	Nicastrin.	0.950
App	Prnp	G3HMG4	G3H416	Amyloid beta A4 protein.	Major prion protein; Belongs to the prion family.	0.924
App	Psen1	G3HMG4	G3HNF2	Amyloid beta A4 protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.971
App	Psen2	G3HMG4	G3HV76	Amyloid beta A4 protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.906
App	Pxdn	G3HMG4	G3HBI1	Amyloid beta A4 protein.	Peroxidasin-like.	0.416
Cav1	CgPICR_017737	G3H9I8	G3I7Y3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Lysosome-associated membrane glycoprotein 1.	0.651
Cav1	Fyn	G3H9I8	G3HMR9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Proto-oncogene tyrosine-protein kinase Fyn.	0.978
Cav1	Lamp1	G3H9I8	G3HK56	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Lysosome-associated membrane glycoprotein 1.	0.651
Cav1	Prnp	G3H9I8	G3H416	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Major prion protein; Belongs to the prion family.	0.936
Cav1	Pxdn	G3H9I8	G3HBI1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Peroxidasin-like.	0.566