STRINGSTRING
Irs1 Irs1 Gcg Gcg I79_015980 I79_015980 Ins Ins PPARG PPARG Gdf11 Gdf11 Acvr2b Acvr2b Smad7 Smad7 Mc4r Mc4r Tgfb3 Tgfb3 Fst Fst Bmp7 Bmp7 Neurog3 Neurog3 I79_000092 I79_000092 CgPICR_017317 CgPICR_017317
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Irs1Insulin receptor substrate 1. (1233 aa)
GcgSeprase; Belongs to the peptidase S9B family. (561 aa)
I79_015980Leptin receptor. (533 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Gdf11Growth/differentiation factor 11. (268 aa)
Acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (559 aa)
Smad7Mothers against decapentaplegic-like 7. (256 aa)
Mc4rMelanocortin receptor 4. (332 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
FstFollistatin. (316 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Neurog3Neurogenin-3. (214 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
CgPICR_017317Insulin receptor substrate 1. (493 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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