STRINGSTRING
Jag1 Jag1 POFUT1 POFUT1 I79_026231 I79_026231 Lmx1b Lmx1b I79_025726 I79_025726 I79_025535 I79_025535 I79_025518 I79_025518 I79_025497 I79_025497 I79_025496 I79_025496 I79_025433 I79_025433 I79_024975 I79_024975 Six1 Six1 Efnb1 Efnb1 I79_021151 I79_021151 I79_020968 I79_020968 Fgf7 Fgf7 I79_019149 I79_019149 Fgf4 Fgf4 Fgf3 Fgf3 Fgf21 Fgf21 Npm3 Npm3 I79_014994 I79_014994 I79_013907 I79_013907 Lmx1a Lmx1a Fgf16 Fgf16 Dll1 Dll1 Gfap Gfap Fgf14 Fgf14 Fgf22 Fgf22 Fgf1 Fgf1 Neurod1 Neurod1 Fgf13 Fgf13 I79_006679 I79_006679 Erbb2 Erbb2 Neurog1 Neurog1 Fgf20 Fgf20 I79_002693 I79_002693 Fgf17 Fgf17 Fgf12 Fgf12 I79_001024 I79_001024 Fgf23 Fgf23 I79_001364 I79_001364 Ntf3 Ntf3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
POFUT1GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] (392 aa)
I79_026231Ephrin-B2; Belongs to the ephrin family. (68 aa)
Lmx1bLIM homeobox transcription factor 1-beta. (233 aa)
I79_025726Ephrin-B2. (121 aa)
I79_025535Ephrin-B2. (125 aa)
I79_025518Ephrin-B2. (123 aa)
I79_025497Ephrin-B2; Belongs to the ephrin family. (69 aa)
I79_025496Ephrin-B2. (147 aa)
I79_025433Ephrin-B2; Belongs to the ephrin family. (70 aa)
I79_024975Ephrin-B2. (148 aa)
Six1Homeobox protein SIX1. (284 aa)
Efnb1Ephrin-B1; Belongs to the ephrin family. (343 aa)
I79_021151Ephrin-B2. (178 aa)
I79_020968Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
I79_019149Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
Fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
Fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
Npm3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
I79_014994Vesicular glutamate transporter 3. (461 aa)
I79_013907Ephrin-B2. (148 aa)
Lmx1aLIM homeobox transcription factor 1-alpha. (333 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
Dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
GfapGlial fibrillary acidic protein; Belongs to the intermediate filament family. (427 aa)
Fgf14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Fgf22Fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (70 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Neurod1Neurogenic differentiation factor. (355 aa)
Fgf13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (117 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Erbb2Receptor protein-tyrosine kinase. (1256 aa)
Neurog1Neurogenin-1. (241 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
I79_002693Netrin-1. (252 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (350 aa)
Fgf12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (165 aa)
I79_001024Ephrin-B2; Belongs to the ephrin family. (373 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
I79_001364Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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