(22 nodes) (2011) Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	I79_022390	Peroxisome proliferator-activated receptor alpha. (110 aa)
	Foxo1	Forkhead box protein O1. (469 aa)
	CgPICR_017317	Insulin receptor substrate 1. (493 aa)
	Abca1	ATP-binding cassette sub-family A member 1. (2261 aa)
	Cidec	Cell death activator CIDE-3. (257 aa)
	I79_003342	Apolipoprotein B-100. (946 aa)
	Apob	Apolipoprotein B-100. (3537 aa)
	Plin4	Perilipin; Belongs to the perilipin family. (381 aa)
	I79_008173	Perilipin; Belongs to the perilipin family. (419 aa)
	Plin3	Perilipin; Belongs to the perilipin family. (440 aa)
	Apoc3	Apolipoprotein C-III. (76 aa)
	I79_021176	Perilipin; Belongs to the perilipin family. (518 aa)
	Irs1	Insulin receptor substrate 1. (1233 aa)
	Trib1	Tribbles-like 1. (286 aa)
	Irs2	Insulin receptor substrate 2. (465 aa)
	Plin2	Perilipin; Belongs to the perilipin family. (432 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (393 aa)
	Akt2	Non-specific serine/threonine protein kinase. (200 aa)
	Xbp1	X-box binding protein 1 isoform 1. (330 aa)
	Insr	Insulin receptor. (114 aa)
	Foxa2	Hepatocyte nuclear factor 3-beta. (430 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abca1	Apob	G3GTZ6	G3GZQ0	ATP-binding cassette sub-family A member 1.	Apolipoprotein B-100.	0.782
Abca1	Apoc3	G3GTZ6	G3I7Q2	ATP-binding cassette sub-family A member 1.	Apolipoprotein C-III.	0.454
Abca1	I79_022390	G3GTZ6	G3IF74	ATP-binding cassette sub-family A member 1.	Peroxisome proliferator-activated receptor alpha.	0.523
Abca1	Ins	G3GTZ6	G3HXZ8	ATP-binding cassette sub-family A member 1.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.522
Abca1	Ppara	G3GTZ6	G3IF76	ATP-binding cassette sub-family A member 1.	Peroxisome proliferator-activated receptor alpha.	0.567
Akt2	CgPICR_017317	G3HNQ3	G3I658	Non-specific serine/threonine protein kinase.	Insulin receptor substrate 1.	0.658
Akt2	Foxo1	G3HNQ3	G3HZV8	Non-specific serine/threonine protein kinase.	Forkhead box protein O1.	0.982
Akt2	Ins	G3HNQ3	G3HXZ8	Non-specific serine/threonine protein kinase.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.710
Akt2	Irs1	G3HNQ3	G3IDC4	Non-specific serine/threonine protein kinase.	Insulin receptor substrate 1.	0.658
Akt2	Irs2	G3HNQ3	G3IKD0	Non-specific serine/threonine protein kinase.	Insulin receptor substrate 2.	0.654
Akt2	Trib1	G3HNQ3	G3IP26	Non-specific serine/threonine protein kinase.	Tribbles-like 1.	0.576
Apob	Abca1	G3GZQ0	G3GTZ6	Apolipoprotein B-100.	ATP-binding cassette sub-family A member 1.	0.782
Apob	Apoc3	G3GZQ0	G3I7Q2	Apolipoprotein B-100.	Apolipoprotein C-III.	0.938
Apob	Foxo1	G3GZQ0	G3HZV8	Apolipoprotein B-100.	Forkhead box protein O1.	0.482
Apob	I79_003342	G3GZQ0	G3GZP9	Apolipoprotein B-100.	Apolipoprotein B-100.	0.943
Apob	I79_022390	G3GZQ0	G3IF74	Apolipoprotein B-100.	Peroxisome proliferator-activated receptor alpha.	0.505
Apob	Ins	G3GZQ0	G3HXZ8	Apolipoprotein B-100.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.763
Apob	Plin2	G3GZQ0	G3IKA3	Apolipoprotein B-100.	Perilipin; Belongs to the perilipin family.	0.405
Apob	Ppara	G3GZQ0	G3IF76	Apolipoprotein B-100.	Peroxisome proliferator-activated receptor alpha.	0.509
Apoc3	Abca1	G3I7Q2	G3GTZ6	Apolipoprotein C-III.	ATP-binding cassette sub-family A member 1.	0.454