(27 nodes) (2011) Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. network (Cricetulus griseus)

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second shell of interactors

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Predicted Interactions

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Your Input:
	CgPICR_017739	Glyceraldehyde-3-phosphate dehydrogenase. (163 aa)
	Adipoq	Adiponectin. (248 aa)
	I79_015980	Leptin receptor. (533 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	CgPICR_013910	Glyceraldehyde-3-phosphate dehydrogenase. (104 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	CgPICR_000709	Glyceraldehyde-3-phosphate dehydrogenase. (148 aa)
	CgPICR_000710	Glyceraldehyde-3-phosphate dehydrogenase. (129 aa)
	CgPICR_002764	Glyceraldehyde-3-phosphate dehydrogenase. (77 aa)
	CgPICR_020194	Glyceraldehyde-3-phosphate dehydrogenase. (105 aa)
	Plek	Pleckstrin. (327 aa)
	Adipor2	Adiponectin receptor protein 2. (386 aa)
	Epor	Erythropoietin receptor. (479 aa)
	Pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Adipor1	Adiponectin receptor protein 1. (375 aa)
	Socs3	Suppressor of cytokine signaling 3. (225 aa)
	Plek2	Pleckstrin-2. (339 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	CgPICR_008588	Glyceraldehyde-3-phosphate dehydrogenase. (161 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (393 aa)
	I79_022390	Peroxisome proliferator-activated receptor alpha. (110 aa)
	I79_022257	Actin. (98 aa)
	Appl1	DCC-interacting protein 13-alpha. (664 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	CgPICR_012401	Glyceraldehyde-3-phosphate dehydrogenase. (75 aa)
	CgPICR_017546	Glyceraldehyde-3-phosphate dehydrogenase. (127 aa)
	CgPICR_002995	Glyceraldehyde-3-phosphate dehydrogenase. (206 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipoq	Adipor1	G3HYG0	G3H3L5	Adiponectin.	Adiponectin receptor protein 1.	0.994
Adipoq	Adipor2	G3HYG0	G3H867	Adiponectin.	Adiponectin receptor protein 2.	0.996
Adipoq	Appl1	G3HYG0	G3GUS8	Adiponectin.	DCC-interacting protein 13-alpha.	0.755
Adipoq	I79_015980	G3HYG0	G3HY62	Adiponectin.	Leptin receptor.	0.702
Adipoq	I79_022390	G3HYG0	G3IF74	Adiponectin.	Peroxisome proliferator-activated receptor alpha.	0.649
Adipoq	Ins	G3HYG0	G3HXZ8	Adiponectin.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.932
Adipoq	Lep	G3HYG0	G3GZ86	Adiponectin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.974
Adipoq	Ppara	G3HYG0	G3IF76	Adiponectin.	Peroxisome proliferator-activated receptor alpha.	0.677
Adipoq	Stat3	G3HYG0	G3HLW9	Adiponectin.	Signal transducer and activator of transcription.	0.423
Adipor1	Adipoq	G3H3L5	G3HYG0	Adiponectin receptor protein 1.	Adiponectin.	0.994
Adipor1	Adipor2	G3H3L5	G3H867	Adiponectin receptor protein 1.	Adiponectin receptor protein 2.	0.975
Adipor1	Appl1	G3H3L5	G3GUS8	Adiponectin receptor protein 1.	DCC-interacting protein 13-alpha.	0.981
Adipor1	I79_015980	G3H3L5	G3HY62	Adiponectin receptor protein 1.	Leptin receptor.	0.410
Adipor1	Ins	G3H3L5	G3HXZ8	Adiponectin receptor protein 1.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.519
Adipor1	Lep	G3H3L5	G3GZ86	Adiponectin receptor protein 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.705
Adipor2	Adipoq	G3H867	G3HYG0	Adiponectin receptor protein 2.	Adiponectin.	0.996
Adipor2	Adipor1	G3H867	G3H3L5	Adiponectin receptor protein 2.	Adiponectin receptor protein 1.	0.975
Adipor2	Appl1	G3H867	G3GUS8	Adiponectin receptor protein 2.	DCC-interacting protein 13-alpha.	0.979
Adipor2	I79_022390	G3H867	G3IF74	Adiponectin receptor protein 2.	Peroxisome proliferator-activated receptor alpha.	0.438
Adipor2	Ins	G3H867	G3HXZ8	Adiponectin receptor protein 2.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.494