(22 nodes) (2011) Chemokines, costimulatory molecules and fusion proteins for the immunotherapy of solid tumors. network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tlr6	Toll-like receptor. (795 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Ctla4	Cytotoxic T-lymphocyte protein 4. (171 aa)
	Tlr9	Toll-like receptor 9. (1239 aa)
	Cxcr4	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
	Cd40	Tumor necrosis factor receptor superfamily member 5. (118 aa)
	Cd86	T-lymphocyte activation antigen CD86. (269 aa)
	Il10	Interleukin-10. (178 aa)
	Ido2	Indoleamine 2,3-dioxygenase 2. (280 aa)
	Ido1	Indoleamine 2,3-dioxygenase 1. (567 aa)
	Ccl21	C-C motif chemokine 21a. (148 aa)
	Ccr8	C-C chemokine receptor type 8-like protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	CgPICR_014700	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Cd80	T-lymphocyte activation antigen CD80. (177 aa)
	Ccr7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	Cxcl12	Stromal cell-derived factor 1. (89 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	Cd34	Hematopoietic progenitor cell antigen CD34. (383 aa)
	Cxcr3	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (286 aa)
	CgPICR_017379	Toll-like receptor 11. (916 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccl21	Ccl5	G3HN19	G3I8B1	C-C motif chemokine 21a.	C-C motif chemokine.	0.648
Ccl21	Ccr7	G3HN19	G3I5N8	C-C motif chemokine 21a.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.999
Ccl21	Ccr8	G3HN19	G3HQW8	C-C motif chemokine 21a.	C-C chemokine receptor type 8-like protein; Belongs to the G-protein coupled receptor 1 family.	0.807
Ccl21	Cd4	G3HN19	G3GUN9	C-C motif chemokine 21a.	T-cell surface glycoprotein CD4.	0.702
Ccl21	Cd80	G3HN19	G3I1J7	C-C motif chemokine 21a.	T-lymphocyte activation antigen CD80.	0.409
Ccl21	Cd86	G3HN19	G3HAJ6	C-C motif chemokine 21a.	T-lymphocyte activation antigen CD86.	0.412
Ccl21	CgPICR_014700	G3HN19	G3HWU4	C-C motif chemokine 21a.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.863
Ccl21	Cxcl12	G3HN19	G3I6P7	C-C motif chemokine 21a.	Stromal cell-derived factor 1.	0.907
Ccl21	Cxcr3	G3HN19	G3IF30	C-C motif chemokine 21a.	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family.	0.927
Ccl21	Cxcr4	G3HN19	G3GZR2	C-C motif chemokine 21a.	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family.	0.928
Ccl21	Ifng	G3HN19	G3GY20	C-C motif chemokine 21a.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.620
Ccl21	Il10	G3HN19	G3HB01	C-C motif chemokine 21a.	Interleukin-10.	0.530
Ccl5	Ccl21	G3I8B1	G3HN19	C-C motif chemokine.	C-C motif chemokine 21a.	0.648
Ccl5	Ccr7	G3I8B1	G3I5N8	C-C motif chemokine.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.954
Ccl5	Ccr8	G3I8B1	G3HQW8	C-C motif chemokine.	C-C chemokine receptor type 8-like protein; Belongs to the G-protein coupled receptor 1 family.	0.978
Ccl5	Cd4	G3I8B1	G3GUN9	C-C motif chemokine.	T-cell surface glycoprotein CD4.	0.874
Ccl5	Cd40	G3I8B1	G3H8U5	C-C motif chemokine.	Tumor necrosis factor receptor superfamily member 5.	0.547
Ccl5	Cd80	G3I8B1	G3I1J7	C-C motif chemokine.	T-lymphocyte activation antigen CD80.	0.510
Ccl5	Cd86	G3I8B1	G3HAJ6	C-C motif chemokine.	T-lymphocyte activation antigen CD86.	0.504
Ccl5	CgPICR_014700	G3I8B1	G3HWU4	C-C motif chemokine.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.993