STRINGSTRING
Ins Ins Adipoq Adipoq Agtr1 Agtr1 I79_002251 I79_002251 Lep Lep I79_009669 I79_009669 Ace Ace I79_009671 I79_009671 I79_009796 I79_009796 H671_xg20748 H671_xg20748 Apoe Apoe Etnk2 Etnk2 PPARG PPARG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
AdipoqAdiponectin. (248 aa)
Agtr1Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
I79_002251Type-1 angiotensin II receptor. (117 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
I79_009669Angiotensin-converting enzyme. (605 aa)
AceAngiotensin-converting enzyme. (791 aa)
I79_009671Angiotensin-converting enzyme. (701 aa)
I79_009796Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (697 aa)
H671_xg20748Angiotensin-converting enzyme. (644 aa)
ApoeApolipoprotein E. (313 aa)
Etnk2Renin; Belongs to the peptidase A1 family. (720 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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