STRINGSTRING
Mboat4 Mboat4 Lep Lep Cry2 Cry2 Ghrl Ghrl Cul4b Cul4b Adipoq Adipoq Jak2 Jak2 I79_021577 I79_021577 Sh2b1 Sh2b1 Per2 Per2 CgPICR_005625 CgPICR_005625 I79_015980 I79_015980 Ins Ins Mc2r Mc2r Cry1 Cry1 Mc4r Mc4r Cck Cck Npy Npy
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mboat4Ghrelin O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (404 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Cry2Cryptochrome-2. (577 aa)
GhrlAppetite-regulating hormone. (100 aa)
Cul4bCullin-4B; Belongs to the cullin family. (834 aa)
AdipoqAdiponectin. (248 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_021577Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
Sh2b1SH2B adapter protein 1. (443 aa)
Per2Period circadian protein-like 2. (1262 aa)
CgPICR_005625Agouti-related protein. (131 aa)
I79_015980Leptin receptor. (533 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
Mc2rAdrenocorticotropic hormone receptor. (297 aa)
Cry1Cryptochrome-1. (428 aa)
Mc4rMelanocortin receptor 4. (332 aa)
CckCholecystokinin. (115 aa)
NpyNeuropeptide Y. (148 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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