39 items (Cricetulus griseus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	Fst	Follistatin. (316 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Rheb	GTP-binding protein Rheb. (179 aa)
	Smad2	Mothers against decapentaplegic homolog. (467 aa)
	Ttn	Titin. (32000 aa)
	Smad3	Mothers against decapentaplegic homolog. (363 aa)
	Cast	Calpastatin. (776 aa)
	Igf1	Insulin-like growth factor I. (75 aa)
	Traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	Traf5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Ghrl	Appetite-regulating hormone. (100 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Casp8	Caspase-8; Belongs to the peptidase C14A family. (481 aa)
	Eif4e	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
	Traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	Ar	Androgen receptor. (517 aa)
	Traf4	TNF receptor-associated factor. (470 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	I79_021949	Caspase-3; Belongs to the peptidase C14A family. (195 aa)
	I79_020089	Caspase-9; Belongs to the peptidase C14A family. (689 aa)
	Foxo4	Forkhead box protein O4. (506 aa)
	I79_019286	Androgen receptor. (295 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2527 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	I79_017669	Apoptotic protease-activating factor 1. (434 aa)
	I79_017529	Apoptotic protease-activating factor 1. (444 aa)
	Foxo1	Forkhead box protein O1. (469 aa)
	I79_016240	Beclin-1. (119 aa)
	Srf	Serum response factor. (361 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (822 aa)
	Sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (147 aa)
	Smad4	Mothers against decapentaplegic-like 4. (259 aa)
	Becn1	Beclin-1. (448 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ar	Foxo1	G3IGU9	G3HZV8	Androgen receptor.	Forkhead box protein O1.	0.566
Ar	I79_019286	G3IGU9	G3I705	Androgen receptor.	Androgen receptor.	0.915
Ar	Igf1	G3IGU9	G3H672	Androgen receptor.	Insulin-like growth factor I.	0.435
Ar	Smad2	G3IGU9	G3HAD0	Androgen receptor.	Mothers against decapentaplegic homolog.	0.406
Ar	Smad3	G3IGU9	G3H8N9	Androgen receptor.	Mothers against decapentaplegic homolog.	0.564
Ar	Smad4	G3IGU9	G3HTR4	Androgen receptor.	Mothers against decapentaplegic-like 4.	0.459
Atg5	Bcl2	G3HVR2	G3HD46	Autophagy protein 5; Involved in autophagic vesicle formation.	Apoptosis regulator Bcl-2.	0.612
Atg5	Becn1	G3HVR2	G3HLZ1	Autophagy protein 5; Involved in autophagic vesicle formation.	Beclin-1.	0.955
Atg5	Casp8	G3HVR2	B2CMK5	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase-8; Belongs to the peptidase C14A family.	0.755
Atg5	Foxo1	G3HVR2	G3HZV8	Autophagy protein 5; Involved in autophagic vesicle formation.	Forkhead box protein O1.	0.466
Atg5	Foxo4	G3HVR2	G3I7K4	Autophagy protein 5; Involved in autophagic vesicle formation.	Forkhead box protein O4.	0.475
Atg5	I79_001600	G3HVR2	G3GV69	Autophagy protein 5; Involved in autophagic vesicle formation.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.581
Atg5	I79_004417	G3HVR2	G3H2K2	Autophagy protein 5; Involved in autophagic vesicle formation.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.581
Atg5	I79_016240	G3HVR2	G3HYU8	Autophagy protein 5; Involved in autophagic vesicle formation.	Beclin-1.	0.955
Atg5	I79_018057	G3HVR2	G3I3P7	Autophagy protein 5; Involved in autophagic vesicle formation.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.581
Atg5	I79_020089	G3HVR2	G3I954	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase-9; Belongs to the peptidase C14A family.	0.546
Atg5	I79_021949	G3HVR2	G3IE08	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase-3; Belongs to the peptidase C14A family.	0.635
Atg5	Mtor	G3HVR2	G3IEE8	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.587
Atg5	Pik3c3	G3HVR2	G3HX36	Autophagy protein 5; Involved in autophagic vesicle formation.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.931
Atg5	Rheb	G3HVR2	G3HB55	Autophagy protein 5; Involved in autophagic vesicle formation.	GTP-binding protein Rheb.	0.561