STRINGSTRING
Adipor1 Adipor1 Igfbp5 Igfbp5 Pcna Pcna Adra1d Adra1d Nck2 Nck2 Eef2 Eef2 Pdk4 Pdk4 Igf1 Igf1 Ghsr Ghsr Adipor2 Adipor2 Smad3 Smad3 Hdac1 Hdac1 Sirt1 Sirt1 Smad2 Smad2 I79_007532 I79_007532 Il10 Il10 Ube2i Ube2i Plin4 Plin4 I79_008173 I79_008173 Plin3 Plin3 Fst Fst Ace Ace Lifr Lifr Hdac2 Hdac2 Il15 Il15 CgPICR_002764 CgPICR_002764 CgPICR_020194 CgPICR_020194 CgPICR_000710 CgPICR_000710 CgPICR_000709 CgPICR_000709 Igfbp3 Igfbp3 Hdac5 Hdac5 Stat3 Stat3 CgPICR_013910 CgPICR_013910 Myd88 Myd88 Ube2o Ube2o PPARG PPARG Mars1 Mars1 Sod2 Sod2 Lima1 Lima1 Gsn Gsn Adipoq Adipoq Hdac4 Hdac4 CgPICR_017739 CgPICR_017739 Myf5 Myf5 CgPICR_002995 CgPICR_002995 CgPICR_005625 CgPICR_005625 Foxo1 Foxo1 CgPICR_017546 CgPICR_017546 Lif Lif Tlr4 Tlr4 IL1B IL1B Ttr Ttr Ep300 Ep300 I79_001343 I79_001343 Azgp1 Azgp1 Bche Bche CgPICR_017317 CgPICR_017317 Epo Epo Nox4 Nox4 Alb Alb Usp19 Usp19 I79_021176 I79_021176 I79_021577 I79_021577 CgPICR_012401 CgPICR_012401 Irs1 Irs1 I79_021949 I79_021949 I79_022257 I79_022257 Bnip3 Bnip3 Hk2 Hk2 Ar Ar CgPICR_008588 CgPICR_008588 Eif4e Eif4e Plin2 Plin2 Irs2 Irs2 Mb Mb I79_025220 I79_025220 I79_025440 I79_025440 Acadm Acadm Ghrl Ghrl Hadha Hadha Ifng Ifng Lep Lep Ctsb Ctsb Npy Npy Akt1 Akt1 Socs3 Socs3 Myog Myog Cs Cs
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Adipor1Adiponectin receptor protein 1. (375 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Adra1dAlpha-1D adrenergic receptor. (485 aa)
Nck2Cytoplasmic protein. (380 aa)
Eef2Elongation factor 2. (872 aa)
Pdk4Protein-serine/threonine kinase. (178 aa)
Igf1Insulin-like growth factor I. (75 aa)
GhsrGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
Adipor2Adiponectin receptor protein 2. (386 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
Hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
I79_007532Elongation factor 2. (52 aa)
Il10Interleukin-10. (178 aa)
Ube2iSUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
Plin4Perilipin; Belongs to the perilipin family. (381 aa)
I79_008173Perilipin; Belongs to the perilipin family. (419 aa)
Plin3Perilipin; Belongs to the perilipin family. (440 aa)
FstFollistatin. (316 aa)
AceAngiotensin-converting enzyme. (791 aa)
LifrLeukemia inhibitory factor receptor. (411 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
CgPICR_002764Glyceraldehyde-3-phosphate dehydrogenase. (77 aa)
CgPICR_020194Glyceraldehyde-3-phosphate dehydrogenase. (105 aa)
CgPICR_000710Glyceraldehyde-3-phosphate dehydrogenase. (129 aa)
CgPICR_000709Glyceraldehyde-3-phosphate dehydrogenase. (148 aa)
Igfbp3Insulin-like growth factor-binding protein 3. (75 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
CgPICR_013910Glyceraldehyde-3-phosphate dehydrogenase. (104 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Ube2oUbiquitin-conjugating enzyme E2 O. (1138 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Mars1Methionyl-tRNA synthetase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (908 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Lima1LIM domain and actin-binding protein 1. (759 aa)
GsnGelsolin. (658 aa)
AdipoqAdiponectin. (248 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
CgPICR_017739Glyceraldehyde-3-phosphate dehydrogenase. (163 aa)
Myf5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
CgPICR_002995Glyceraldehyde-3-phosphate dehydrogenase. (206 aa)
CgPICR_005625Agouti-related protein. (131 aa)
Foxo1Forkhead box protein O1. (469 aa)
CgPICR_017546Glyceraldehyde-3-phosphate dehydrogenase. (127 aa)
LifLeukemia inhibitory factor-like protein. (158 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
TtrTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (147 aa)
Ep300Histone acetyltransferase p300. (2415 aa)
I79_001343Alpha-2-macroglobulin. (1664 aa)
Azgp1Zinc-alpha-2-glycoprotein; Belongs to the MHC class I family. (306 aa)
BcheCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (507 aa)
CgPICR_017317Insulin receptor substrate 1. (493 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
Nox4NADPH oxidase 4. (130 aa)
AlbSerum albumin. (430 aa)
Usp19Ubiquitin carboxyl-terminal hydrolase 19. (1357 aa)
I79_021176Perilipin; Belongs to the perilipin family. (518 aa)
I79_021577Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
CgPICR_012401Glyceraldehyde-3-phosphate dehydrogenase. (75 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
I79_022257Actin. (98 aa)
Bnip3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (151 aa)
Hk2Hexokinase-2. (704 aa)
ArAndrogen receptor. (517 aa)
CgPICR_008588Glyceraldehyde-3-phosphate dehydrogenase. (161 aa)
Eif4eEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
Plin2Perilipin; Belongs to the perilipin family. (432 aa)
Irs2Insulin receptor substrate 2. (465 aa)
MbMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
I79_025220Serum albumin. (186 aa)
I79_025440Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
AcadmMedium-chain specific acyl-CoA dehydrogenase, mitochondrial. (96 aa)
GhrlAppetite-regulating hormone. (100 aa)
HadhaTrifunctional enzyme subunit alpha, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CtsbCathepsin B; Belongs to the peptidase C1 family. (339 aa)
NpyNeuropeptide Y. (148 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Socs3Suppressor of cytokine signaling 3. (225 aa)
MyogMyogenin. (224 aa)
CsCitrate synthase; Belongs to the citrate synthase family. (313 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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