(57 nodes) (2012) Cell biology of ischemiareperfusion injury. network (Cricetulus griseus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	ICAM1	Intercellular adhesion molecule 1. (527 aa)
	Gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	Mb	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	F3	Tissue factor. (293 aa)
	Bnip3	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (151 aa)
	I79_022257	Actin. (98 aa)
	I79_021949	Caspase-3; Belongs to the peptidase C14A family. (195 aa)
	Vcam1	Vascular cell adhesion protein 1. (220 aa)
	I79_021045	Heme oxygenase 1. (81 aa)
	Hmox1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	I79_020102	Histone H2A; Belongs to the histone H2A family. (143 aa)
	I79_020089	Caspase-9; Belongs to the peptidase C14A family. (689 aa)
	HSPA5	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
	Htra2	Serine protease HTRA2, mitochondrial. (448 aa)
	Apoa5	Apolipoprotein A-V. (363 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (813 aa)
	Pdcd4	Programmed cell death protein 4. (469 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Tradd	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (306 aa)
	I79_016240	Beclin-1. (119 aa)
	Xpo5	Exportin-5. (1204 aa)
	I79_016164	P-selectin. (1330 aa)
	Stat6	Signal transducer and activator of transcription. (844 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (147 aa)
	Atf6	Cyclic AMP-dependent transcription factor ATF-6 alpha. (659 aa)
	Ocln	Occludin. (488 aa)
	Stat2	Signal transducer and activator of transcription. (806 aa)
	Fadd	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	Becn1	Beclin-1. (448 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	I79_011712	Signal transducer and activator of transcription. (793 aa)
	Thbs1	Thrombospondin-1. (533 aa)
	H671_xg20748	Angiotensin-converting enzyme. (644 aa)
	I79_009671	Angiotensin-converting enzyme. (701 aa)
	Ace	Angiotensin-converting enzyme. (791 aa)
	I79_009669	Angiotensin-converting enzyme. (605 aa)
	Cd47	Leukocyte surface antigen CD47. (268 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Drosha	Ribonuclease 3. (1372 aa)
	Il10	Interleukin-10. (178 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (554 aa)
	Cd40	Tumor necrosis factor receptor superfamily member 5. (118 aa)
	Manf	Mesencephalic astrocyte-derived neurotrophic factor. (217 aa)
	Cast	Calpastatin. (776 aa)
	Mcl1	Putative induced myeloid leukemia cell differentiation protein Mcl-1 like protein. (120 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Edn1	Endothelin-1. (202 aa)
	Casp8	Caspase-8; Belongs to the peptidase C14A family. (481 aa)
	Kcnj2	Inward rectifier potassium channel 2. (427 aa)
	I79_001376	Von Willebrand factor. (3626 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Cd163	Scavenger receptor cysteine-rich type 1 protein M130. (497 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	Cd4	G3I7E3	G3GUN9	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	T-cell surface glycoprotein CD4.	0.492
AGO2	Drosha	G3I7E3	G3HCB2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Ribonuclease 3.	0.939
AGO2	Pdcd4	G3I7E3	G3I6S3	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Programmed cell death protein 4.	0.491
AGO2	Xpo5	G3I7E3	G3HYU7	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Exportin-5.	0.886
Ace	Cd4	G3HGE5	G3GUN9	Angiotensin-converting enzyme.	T-cell surface glycoprotein CD4.	0.577
Ace	Edn1	G3HGE5	G3H0G9	Angiotensin-converting enzyme.	Endothelin-1.	0.650
Ace	H671_xg20748	G3HGE5	G3HH90	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.456
Ace	I79_001376	G3HGE5	G3GUL3	Angiotensin-converting enzyme.	Von Willebrand factor.	0.427
Ace	I79_016164	G3HGE5	G3HYM3	Angiotensin-converting enzyme.	P-selectin.	0.418
Ace	I79_022257	G3HGE5	G3IEV3	Angiotensin-converting enzyme.	Actin.	0.410
Ace	ICAM1	G3HGE5	Q9ERF7	Angiotensin-converting enzyme.	Intercellular adhesion molecule 1.	0.497
Ace	Ifng	G3HGE5	G3GY20	Angiotensin-converting enzyme.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.424
Ace	Il10	G3HGE5	G3HB01	Angiotensin-converting enzyme.	Interleukin-10.	0.440
Ace	Vcam1	G3HGE5	G3ID63	Angiotensin-converting enzyme.	Vascular cell adhesion protein 1.	0.526
Atf6	Atg5	G3HTZ9	G3HVR2	Cyclic AMP-dependent transcription factor ATF-6 alpha.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.516
Atf6	Bcl2	G3HTZ9	G3HD46	Cyclic AMP-dependent transcription factor ATF-6 alpha.	Apoptosis regulator Bcl-2.	0.422
Atf6	HSPA5	G3HTZ9	G3I8R9	Cyclic AMP-dependent transcription factor ATF-6 alpha.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.997
Atf6	I79_020089	G3HTZ9	G3I954	Cyclic AMP-dependent transcription factor ATF-6 alpha.	Caspase-9; Belongs to the peptidase C14A family.	0.550
Atf6	I79_021949	G3HTZ9	G3IE08	Cyclic AMP-dependent transcription factor ATF-6 alpha.	Caspase-3; Belongs to the peptidase C14A family.	0.594
Atf6	Manf	G3HTZ9	G3H8A8	Cyclic AMP-dependent transcription factor ATF-6 alpha.	Mesencephalic astrocyte-derived neurotrophic factor.	0.612