(12 nodes) (2012) Sink or swim: lipid rafts in parasite pathogenesis. network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Lyrm9	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
	Nos1	Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
	Cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	Cd40	Tumor necrosis factor receptor superfamily member 5. (118 aa)
	Cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Il10	Interleukin-10. (178 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Il15	Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Sdf4	45 kDa calcium-binding protein. (355 aa)
	I79_022257	Actin. (98 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cav1	Cav2	G3H9I8	G3H9I7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.998
Cav1	Cav3	G3H9I8	G3H113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.938
Cav1	I79_007693	G3H9I8	G3HB72	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.776
Cav1	I79_022257	G3H9I8	G3IEV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Actin.	0.725
Cav1	Lyrm9	G3H9I8	G3GTQ5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family.	0.496
Cav1	Nos1	G3H9I8	G3GU55	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.610
Cav2	Cav1	G3H9I7	G3H9I8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.998
Cav2	Cav3	G3H9I7	G3H113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.994
Cav2	I79_007693	G3H9I7	G3HB72	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.415
Cav2	I79_022257	G3H9I7	G3IEV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Actin.	0.675
Cav3	Cav1	G3H113	G3H9I8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.938
Cav3	Cav2	G3H113	G3H9I7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.994
Cav3	I79_007693	G3H113	G3HB72	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.612
Cav3	I79_022257	G3H113	G3IEV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Actin.	0.674
Cav3	Lyrm9	G3H113	G3GTQ5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family.	0.461
Cav3	Nos1	G3H113	G3GU55	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.638
Cd40	Il10	G3H8U5	G3HB01	Tumor necrosis factor receptor superfamily member 5.	Interleukin-10.	0.858
Cd40	Il15	G3H8U5	G3HJ60	Tumor necrosis factor receptor superfamily member 5.	Interleukin; Belongs to the IL-15/IL-21 family.	0.614
Cd40	Tnf	G3H8U5	G3HZG9	Tumor necrosis factor receptor superfamily member 5.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.772
I79_007693	Cav1	G3HB72	G3H9I8	Nitric oxide synthase; Produces nitric oxide (NO).	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.776